Ian Murray

Affiliate Researcher

In the News

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Recent Publications

Molecular networking identifies an AHR-modulating benzothiazole from white button mushrooms (Agaricus bisporus)

Chen, X., Patterson, A. D., Perdew, G. H., Murray, I. A. & Kellogg, J. J., Jul 2023, In: Journal of Functional Foods. 106, 105602.

Research output: Contribution to journalArticlepeer-review

Complex chemical signals dictate Ah receptor activation through the gut-lung axis

Dong, F., Murray, I. A., Annalora, A., Coslo, D. M., Desai, D., Gowda, K., Yang, J., Wang, D., Koo, I., Hao, F., Amin, S. G., Patterson, A. D., Marcus, C. & Perdew, G. H., Jul 1 2023, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37, 7, p. e23010

Research output: Contribution to journalArticlepeer-review

Endogenous Tryptophan-Derived Ah Receptor Ligands are Dissociated from CYP1A1/1B1-Dependent Negative-Feedback

Dong, F., Annalora, A. J., Murray, I. A., Tian, Y., Marcus, C. B., Patterson, A. D. & Perdew, G. H., Jan 1 2023, In: International Journal of Tryptophan Research. 16

Research output: Contribution to journalArticlepeer-review

Third generation quinoline-3-carboxamide transcriptional disrupter of HDAC4, HIF-1α, and MEF-2 signaling for metastatic castration-resistant prostate cancer

Isaacs, J. T., Dalrymple, S. L., Antony, L., Marc Rosen, D., Coleman, I. M., Nelson, P. S., Kostova, M., Murray, I. A., Perdew, G. H., Denmeade, S. R., Akinboye, E. S. & Brennen, W. N., Nov 2023, In: Prostate. 83, 15, p. 1470-1493 24 p.

Research output: Contribution to journalArticlepeer-review

Contribution of Circulating Host and Microbial Tryptophan Metabolites Toward Ah Receptor Activation

Morgan, E. W., Dong, F., Annalora, A. J., Murray, I. A., Wolfe, T., Erickson, R., Gowda, K., Amin, S. G., Petersen, K. S., Kris-Etherton, P. M., Marcus, C. B., Walk, S. T., Patterson, A. D. & Perdew, G. H., Jan 1 2023, In: International Journal of Tryptophan Research. 16

Research output: Contribution to journalArticlepeer-review

Induction of AHR Signaling in Response to the Indolimine Class of Microbial Stress Metabolites

Patel, D., Murray, I. A., Dong, F., Annalora, A. J., Gowda, K., Coslo, D. M., Krzeminski, J., Koo, I., Hao, F., Amin, S. G., Marcus, C. B., Patterson, A. D. & Perdew, G. H., Sep 2023, In: Metabolites. 13, 9, 985.

Research output: Contribution to journalArticlepeer-review

Lead optimization of aryl hydrocarbon receptor ligands for treatment of inflammatory skin disorders

Rikken, G., Smith, K. J., van den Brink, N. J. M., Smits, J. P. H., Gowda, K., Alnemri, A., Kuzu, G. E., Murray, I. A., Lin, J. M., Smits, J. G. A., van Vlijmen-Willems, I. M., Amin, S. G., Perdew, G. H. & van den Bogaard, E. H., Feb 2023, In: Biochemical Pharmacology. 208, 115400.

Research output: Contribution to journalArticlepeer-review

Aryl Hydrocarbon Receptor Activation Coordinates Mouse Small Intestinal Epithelial Cell Programming

Zhou, X., Chakraborty, D., Murray, I. A., Coslo, D., Kehs, Z., Vijay, A., Ton, C., Desai, D., Amin, S. G., Patterson, A. D. & Perdew, G. H., Feb 1 2023, In: Laboratory Investigation. 103, 2, p. 100012 1 p.

Research output: Contribution to journalArticlepeer-review

The aryl hydrocarbon receptor activates ceramide biosynthesis in mice contributing to hepatic lipogenesis

Liu, Q., Zhang, L., Allman, E. L., Hubbard, T. D., Murray, I. A., Hao, F., Tian, Y., Gui, W., Nichols, R. G., Smith, P. B., Anitha, M., Perdew, G. H. & Patterson, A. D., Jun 30 2021, In: Toxicology. 458, 152831.

Research output: Contribution to journalArticlepeer-review

Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity

Dong, F., Hao, F., Murray, I. A., Smith, P. B., Koo, I., Tindall, A. M., Kris-Etherton, P. M., Gowda, K., Amin, S. G., Patterson, A. D. & Perdew, G. H., Nov 9 2020, In: Gut microbes. 12, 1, p. 1-24 24 p.

Research output: Contribution to journalArticlepeer-review

Targeting the pregnane X receptor using microbial metabolite mimicry

Dvořák, Z., Kopp, F., Costello, C. M., Kemp, J. S., Li, H., Vrzalová, A., Štěpánková, M., Bartoňková, I., Jiskrová, E., Poulíková, K., Vyhlídalová, B., Nordstroem, L. U., Karunaratne, C. V., Ranhotra, H. S., Mun, K. S., Naren, A. P., Murray, I. A., Perdew, G. H., Brtko, J., Toporova, L., & 22 othersSchön, A., Wallace, W. G., Walton, W. G., Redinbo, M. R., Sun, K., Beck, A., Kortagere, S., Neary, M. C., Chandran, A., Vishveshwara, S., Cavalluzzi, M. M., Lentini, G., Cui, J. Y., Gu, H., March, J. C., Chatterjee, S., Matson, A., Wright, D., Flannigan, K. L., Hirota, S. A., Sartor, R. B. & Mani, S., Apr 7 2020, In: EMBO Molecular Medicine. 12, 4, e11621.

Research output: Contribution to journalArticlepeer-review

Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity

Muku, G. E., Kusnadi, A., Kuzu, G., Tanos, R., Murray, I. A., Gowda, K., Amin, S. & Perdew, G. H., Feb 1 2020, In: Laboratory Investigation. 100, 2, p. 250-264 15 p.

Research output: Contribution to journalArticlepeer-review

How ah receptor ligand specificity became important in understanding its physiological function

Murray, I. A. & Perdew, G. H., Dec 2 2020, In: International journal of molecular sciences. 21, 24, p. 1-19 19 p., 9614.

Research output: Contribution to journalReview articlepeer-review

Metatranscriptomic analysis of the mouse gut microbiome response to the persistent organic pollutant 2,3,7,8-tetrachlorodibenzofuran

Nichols, R. G., Zhang, J., Cai, J., Murray, I. A., Koo, I., Smith, P. B., Perdew, G. H. & Patterson, A. D., Jan 2020, In: Metabolites. 10, 1, 1.

Research output: Contribution to journalArticlepeer-review

Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline

Hubbard, T. D., Liu, Q., Murray, I. A., Dong, F., Miller, C., Smith, P. B., Gowda, K., Lin, J. M., Amin, S., Patterson, A. D. & Perdew, G. H., Apr 5 2019, In: Journal of Proteome Research. 18, 4, p. 1715-1724 10 p.

Research output: Contribution to journalArticlepeer-review