Research Keywords
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Recent Publications
The aryl hydrocarbon receptor activates ceramide biosynthesis in mice contributing to hepatic lipogenesis
Liu, Q., Zhang, L., Allman, E. L., Hubbard, T. D., Murray, I. A., Hao, F., Tian, Y., Gui, W., Nichols, R. G., Smith, P. B., Anitha, M., Perdew, G. H. & Patterson, A. D., Jun 30 2021, In: Toxicology. 458, 152831.Research output: Contribution to journal › Article › peer-review
Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity
Dong, F., Hao, F., Murray, I. A., Smith, P. B., Koo, I., Tindall, A. M., Kris-Etherton, P. M., Gowda, K., Amin, S. G., Patterson, A. D. & Perdew, G. H., Nov 9 2020, In: Gut microbes. 12, 1, p. 1-24 24 p.Research output: Contribution to journal › Article › peer-review
Targeting the pregnane X receptor using microbial metabolite mimicry
Dvořák, Z., Kopp, F., Costello, C. M., Kemp, J. S., Li, H., Vrzalová, A., Štěpánková, M., Bartoňková, I., Jiskrová, E., Poulíková, K., Vyhlídalová, B., Nordstroem, L. U., Karunaratne, C. V., Ranhotra, H. S., Mun, K. S., Naren, A. P., Murray, I. A., Perdew, G. H., Brtko, J., Toporova, L., & 22 others, Apr 7 2020, In: EMBO Molecular Medicine. 12, 4, e11621.Research output: Contribution to journal › Article › peer-review
Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity
Muku, G. E., Kusnadi, A., Kuzu, G., Tanos, R., Murray, I. A., Gowda, K., Amin, S. & Perdew, G. H., Feb 1 2020, In: Laboratory Investigation. 100, 2, p. 250-264 15 p.Research output: Contribution to journal › Article › peer-review
How ah receptor ligand specificity became important in understanding its physiological function
Murray, I. A. & Perdew, G. H., Dec 2 2020, In: International journal of molecular sciences. 21, 24, p. 1-19 19 p., 9614.Research output: Contribution to journal › Review article › peer-review
Metatranscriptomic analysis of the mouse gut microbiome response to the persistent organic pollutant 2,3,7,8-tetrachlorodibenzofuran
Nichols, R. G., Zhang, J., Cai, J., Murray, I. A., Koo, I., Smith, P. B., Perdew, G. H. & Patterson, A. D., Jan 2020, In: Metabolites. 10, 1, 1.Research output: Contribution to journal › Article › peer-review
Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline
Hubbard, T. D., Liu, Q., Murray, I. A., Dong, F., Miller, C., Smith, P. B., Gowda, K., Lin, J. M., Amin, S., Patterson, A. D. & Perdew, G. H., Apr 5 2019, In: Journal of Proteome Research. 18, 4, p. 1715-1724 10 p.Research output: Contribution to journal › Article › peer-review
Activation of the Ah Receptor Modulates Gastrointestinal Homeostasis and the Intestinal Microbiome
Muku, G. E., Murray, I. A. & Perdew, G. H., Oct 1 2019, In: Current Pharmacology Reports. 5, 5, p. 319-331 13 p.Research output: Contribution to journal › Review article › peer-review
Selective Ah Receptor Ligands Mediate Enhanced SREBP1 Proteolysis to Restrict Lipogenesis in Sebocytes
Muku, G. E., Blazanin, N., Dong, F., Smith, P. B., Thiboutot, D., Gowda, K., Amin, S., Murray, I. A. & Perdew, G. H., Sep 1 2019, In: Toxicological Sciences. 171, 1, p. 146-158 13 p.Research output: Contribution to journal › Article › peer-review
Isolation and Identification of Aryl Hydrocarbon Receptor Modulators in White Button Mushrooms (Agaricus bisporus)
Tian, Y., Gui, W., Smith, P. B., Koo, I., Murray, I. A., Cantorna, M. T., Perdew, G. H. & Patterson, A. D., May 23 2019, In: Journal of agricultural and food chemistry. 67, 33, p. 9286-9294 9 p.Research output: Contribution to journal › Article › peer-review
Urolithin a is a dietary microbiota-derived human aryl hydrocarbon receptor antagonist
Muku, G. E., Murray, I. A., Espín, J. C. & Perdew, G. H., Dec 2018, In: Metabolites. 8, 4Research output: Contribution to journal › Article › peer-review
Structural and Functional Analysis of the Gut Microbiome for Toxicologists
Nichols, R. G., Cai, J., Murray, I. A., Koo, I., Smith, P. B., Perdew, G. H. & Patterson, A. D., Nov 2018, In: Current Protocols in Toxicology. 78, 1, e54.Research output: Contribution to journal › Article › peer-review
Allelic variants of the aryl hydrocarbon receptor differentially influence UVB-mediated skin inflammatory responses in SKH1 mice
Smith, K. J., Murray, I. A., Boyer, J. A. & Perdew, G. H., Feb 1 2018, In: Toxicology. 394, p. 27-34 8 p.Research output: Contribution to journal › Article › peer-review
Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner
Hubbard, T. D., Murray, I. A., Nichols, R. G., Cassel, K., Podolsky, M., Kuzu, G., Tian, Y., Smith, P., Kennett, M. J., Patterson, A. D. & Perdew, G. H., Oct 2017, In: Journal of Functional Foods. 37, p. 685-698 14 p.Research output: Contribution to journal › Article › peer-review
Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors activate the aryl hydrocarbon receptor
Moyer, B. J., Rojas, I. Y., Murray, I. A., Lee, S., Hazlett, H. F., Perdew, G. H. & Tomlinson, C. R., May 15 2017, In: Toxicology and Applied Pharmacology. 323, p. 74-80 7 p.Research output: Contribution to journal › Article › peer-review