Ian Murray

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Assistant Research Professor, Center for Molecular Toxicology & Carcinogenesis

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Recent Publications

The aryl hydrocarbon receptor activates ceramide biosynthesis in mice contributing to hepatic lipogenesis

Liu, Q., Zhang, L., Allman, E. L., Hubbard, T. D., Murray, I. A., Hao, F., Tian, Y., Gui, W., Nichols, R. G., Smith, P. B., Anitha, M., Perdew, G. H. & Patterson, A. D., Jun 30 2021, In: Toxicology. 458, 152831.

Research output: Contribution to journalArticlepeer-review

Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity

Dong, F., Hao, F., Murray, I. A., Smith, P. B., Koo, I., Tindall, A. M., Kris-Etherton, P. M., Gowda, K., Amin, S. G., Patterson, A. D. & Perdew, G. H., Nov 9 2020, In: Gut microbes. 12, 1, p. 1-24 24 p.

Research output: Contribution to journalArticlepeer-review

Targeting the pregnane X receptor using microbial metabolite mimicry

Dvořák, Z., Kopp, F., Costello, C. M., Kemp, J. S., Li, H., Vrzalová, A., Štěpánková, M., Bartoňková, I., Jiskrová, E., Poulíková, K., Vyhlídalová, B., Nordstroem, L. U., Karunaratne, C. V., Ranhotra, H. S., Mun, K. S., Naren, A. P., Murray, I. A., Perdew, G. H., Brtko, J., Toporova, L., & 22 othersSchön, A., Wallace, W. G., Walton, W. G., Redinbo, M. R., Sun, K., Beck, A., Kortagere, S., Neary, M. C., Chandran, A., Vishveshwara, S., Cavalluzzi, M. M., Lentini, G., Cui, J. Y., Gu, H., March, J. C., Chatterjee, S., Matson, A., Wright, D., Flannigan, K. L., Hirota, S. A., Sartor, R. B. & Mani, S., Apr 7 2020, In: EMBO Molecular Medicine. 12, 4, e11621.

Research output: Contribution to journalArticlepeer-review

Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity

Muku, G. E., Kusnadi, A., Kuzu, G., Tanos, R., Murray, I. A., Gowda, K., Amin, S. & Perdew, G. H., Feb 1 2020, In: Laboratory Investigation. 100, 2, p. 250-264 15 p.

Research output: Contribution to journalArticlepeer-review

How ah receptor ligand specificity became important in understanding its physiological function

Murray, I. A. & Perdew, G. H., Dec 2 2020, In: International journal of molecular sciences. 21, 24, p. 1-19 19 p., 9614.

Research output: Contribution to journalReview articlepeer-review

Metatranscriptomic analysis of the mouse gut microbiome response to the persistent organic pollutant 2,3,7,8-tetrachlorodibenzofuran

Nichols, R. G., Zhang, J., Cai, J., Murray, I. A., Koo, I., Smith, P. B., Perdew, G. H. & Patterson, A. D., Jan 2020, In: Metabolites. 10, 1, 1.

Research output: Contribution to journalArticlepeer-review

Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline

Hubbard, T. D., Liu, Q., Murray, I. A., Dong, F., Miller, C., Smith, P. B., Gowda, K., Lin, J. M., Amin, S., Patterson, A. D. & Perdew, G. H., Apr 5 2019, In: Journal of Proteome Research. 18, 4, p. 1715-1724 10 p.

Research output: Contribution to journalArticlepeer-review

Activation of the Ah Receptor Modulates Gastrointestinal Homeostasis and the Intestinal Microbiome

Muku, G. E., Murray, I. A. & Perdew, G. H., Oct 1 2019, In: Current Pharmacology Reports. 5, 5, p. 319-331 13 p.

Research output: Contribution to journalReview articlepeer-review

Selective Ah Receptor Ligands Mediate Enhanced SREBP1 Proteolysis to Restrict Lipogenesis in Sebocytes

Muku, G. E., Blazanin, N., Dong, F., Smith, P. B., Thiboutot, D., Gowda, K., Amin, S., Murray, I. A. & Perdew, G. H., Sep 1 2019, In: Toxicological Sciences. 171, 1, p. 146-158 13 p.

Research output: Contribution to journalArticlepeer-review

Isolation and Identification of Aryl Hydrocarbon Receptor Modulators in White Button Mushrooms (Agaricus bisporus)

Tian, Y., Gui, W., Smith, P. B., Koo, I., Murray, I. A., Cantorna, M. T., Perdew, G. H. & Patterson, A. D., May 23 2019, In: Journal of agricultural and food chemistry. 67, 33, p. 9286-9294 9 p.

Research output: Contribution to journalArticlepeer-review

Urolithin a is a dietary microbiota-derived human aryl hydrocarbon receptor antagonist

Muku, G. E., Murray, I. A., Espín, J. C. & Perdew, G. H., Dec 2018, In: Metabolites. 8, 4

Research output: Contribution to journalArticlepeer-review

Structural and Functional Analysis of the Gut Microbiome for Toxicologists

Nichols, R. G., Cai, J., Murray, I. A., Koo, I., Smith, P. B., Perdew, G. H. & Patterson, A. D., Nov 2018, In: Current Protocols in Toxicology. 78, 1, e54.

Research output: Contribution to journalArticlepeer-review

Allelic variants of the aryl hydrocarbon receptor differentially influence UVB-mediated skin inflammatory responses in SKH1 mice

Smith, K. J., Murray, I. A., Boyer, J. A. & Perdew, G. H., Feb 1 2018, In: Toxicology. 394, p. 27-34 8 p.

Research output: Contribution to journalArticlepeer-review

Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner

Hubbard, T. D., Murray, I. A., Nichols, R. G., Cassel, K., Podolsky, M., Kuzu, G., Tian, Y., Smith, P., Kennett, M. J., Patterson, A. D. & Perdew, G. H., Oct 2017, In: Journal of Functional Foods. 37, p. 685-698 14 p.

Research output: Contribution to journalArticlepeer-review

Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors activate the aryl hydrocarbon receptor

Moyer, B. J., Rojas, I. Y., Murray, I. A., Lee, S., Hazlett, H. F., Perdew, G. H. & Tomlinson, C. R., May 15 2017, In: Toxicology and Applied Pharmacology. 323, p. 74-80 7 p.

Research output: Contribution to journalArticlepeer-review