Center for Quantitative Imaging

3D MicroCT Scanning at Penn State

The Center for Quantitative Imaging provides clients with detailed, non-destructive microCT imaging.

The center focuses on two main areas of research: monitoring internal processes in experimental systems and characterizing complex three-dimensional (3D) structure and material composition in natural and synthetic systems. 

The technology of microCT scanning creates high-resolution three-dimensional 3D images by using x-rays. To do this, the microCT scanner collects two-dimensional (2D) trans-axial projections (or slices) of the scanned material/specimen. Once collected, the slices are then reconstructed into a full 3D model. 

Lab technicians work closely with clients to understand the objectives and offer the best possible solutions, collaborate on the process, and deliver the finest images for the client.

The Center for Quantitative Imaging's services are available to Penn State researchers as well as researchers at other institutions and industry. 

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The Center for Quantitative Imaging is available to assist both Penn State researchers and external clients from industry, government, and other universities.

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Innovating Together

Center for Quantitative Imaging technicians have worked with clients on a wide variety of projects. They have also innovated together on new procedures and methods to create the best possible image, including staining, mounting, preserving, and positioning.

Capabilities

Zeiss Versa 620

The Versa provides 40 nm voxel resolution, 100 mm maximum sample width, and 300 mm maximum sample height. This non-destructive system provides three-dimensional imaging of biotic and abiotic materials, data output is quantitative and can serve as input for numerical modeling.

General Electric Micro-Nano CT System

The General Electric v|tome|x L300 nano/microCT offers high-resolution imaging with feature detectability of 1 micron, and 1200 mm maximum sample height.

Center for Quantitative Imaging in Action

Research collaborations with the Center for Quantitative Imaging

CQI collaborates on new procedures to improve high-quality scanning

Center for Quantitative Imaging techs collaborated on two techniques that allowed for the collection of high-quality, information-dense image data on small, delicate specimens: a solution-based staining process that produced more tissue contrast, providing detail-rich images and a wax-mounting protocol that protected and stabilized specimens.

Scanning brains of zebrafish

Researchers and Center for Quantitative Imaging staff worked with contrast-enhanced Micro-CT to quantify detailed neuroanatomical information of intact adult zebrafish brains and developed a staining protocol that will reduce tissue distortion and a mounting procedure that will mitigate scanning artifacts, enabling this technique to be used as a tool for visualizing small-scale differences in neural tissue.

Center for Quantitative Imaging Staff

Address

Center for Quantitative Imaging
416 Academic Activities Building
University Park, PA 16802