Andrew Patterson

Affiliate Researcher
Titles and Affiliations
Professor, Veterinary and Biomedical Sciences

Research Summary

Research is focused on defining the role of PPARa in mitochondrial dysfunction associated with drug-induced hepatotoxicity. Perhaps the most critical role of PPARa is to modulate hepatic fatty acid catabolism. Research utilizes mouse models, traditional biochemistry and molecular biology techniques, as well as cutting-edge and highly sophisticated metabolomic approaches to understand the molecular mechanisms associated with PPARa activity.

In the News

Research Keywords

Projects

Recent Publications

Individualized microbiotas dictate the impact of dietary fiber on colitis sensitivity

Bonazzi, E., Bretin, A., Vigué, L., Hao, F., Patterson, A. D., Gewirtz, A. T. & Chassaing, B., Dec 2024, In: Microbiome. 12, 1, 5.

Research output: Contribution to journalArticlepeer-review

Immune cell-intrinsic Ah receptor facilitates the expression of antimicrobial REG3G in the small intestine

Chakraborty, D., Coslo, D. M., Murray, I. A., Vijay, A., Patterson, A. D. & Perdew, G. H., Feb 29 2024, In: FASEB Journal. 38, 4, e23471.

Research output: Contribution to journalArticlepeer-review

Human Intestinal Microbiome Determines Individualized Inflammatory Response to Dietary Emulsifier Carboxymethylcellulose Consumption

Daniel, N., Wu, G. D., Walters, W., Compher, C., Ni, J., Delaroque, C., Albenberg, L., Ley, R. E., Patterson, A. D., Lewis, J. D., Gewirtz, A. T. & Chassaing, B., Jan 2024, In: CMGH. 17, 2, p. 315-318 4 p.

Research output: Contribution to journalShort surveypeer-review

Reverse metabolomics for the discovery of chemical structures from humans

Gentry, E. C., Collins, S. L., Panitchpakdi, M., Belda-Ferre, P., Stewart, A. K., Carrillo Terrazas, M., Lu, H. H., Zuffa, S., Yan, T., Avila-Pacheco, J., Plichta, D. R., Aron, A. T., Wang, M., Jarmusch, A. K., Hao, F., Syrkin-Nikolau, M., Vlamakis, H., Ananthakrishnan, A. N., Boland, B. S., Hemperly, A., & 10 othersVande Casteele, N., Gonzalez, F. J., Clish, C. B., Xavier, R. J., Chu, H., Baker, E. S., Patterson, A. D., Knight, R., Siegel, D. & Dorrestein, P. C., Feb 8 2024, In: Nature. 626, 7998, p. 419-426 8 p.

Research output: Contribution to journalArticlepeer-review

Magnetic field and ultrasound induced simultaneous wireless energy harvesting

Karan, S. K., Hosur, S., Kashani, Z., Leng, H., Vijay, A., Sriramdas, R., Wang, K., Poudel, B., Patterson, A. D., Kiani, M. & Priya, S., Jan 24 2024, In: Energy and Environmental Science. 17, 6, p. 2129-2144 16 p.

Research output: Contribution to journalArticlepeer-review

Bile salt hydrolase catalyses formation of amine-conjugated bile acids

Rimal, B., Collins, S. L., Tanes, C. E., Rocha, E. R., Granda, M. A., Solanki, S., Hoque, N. J., Gentry, E. C., Koo, I., Reilly, E. R., Hao, F., Paudel, D., Singh, V., Yan, T., Kim, M. S., Bittinger, K., Zackular, J. P., Krausz, K. W., Desai, D., Amin, S., & 10 othersColeman, J. P., Shah, Y. M., Bisanz, J. E., Gonzalez, F. J., Vanden Heuvel, J. P., Wu, G. D., Zemel, B. S., Dorrestein, P. C., Weinert, E. E. & Patterson, A. D., Feb 22 2024, In: Nature. 626, 8000, p. 859-863 5 p.

Research output: Contribution to journalArticlepeer-review

microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data

Zuffa, S., Schmid, R., Bauermeister, A., Paulo, P. W., Caraballo-Rodriguez, A. M., El Abiead, Y., Aron, A. T., Gentry, E. C., Zemlin, J., Meehan, M. J., Avalon, N. E., Cichewicz, R. H., Buzun, E., Terrazas, M. C., Hsu, C. Y., Oles, R., Ayala, A. V., Zhao, J., Chu, H., Kuijpers, M. C. M., & 89 othersJackrel, S. L., Tugizimana, F., Nephali, L. P., Dubery, I. A., Madala, N. E., Moreira, E. A., Costa-Lotufo, L. V., Lopes, N. P., Rezende-Teixeira, P., Jimenez, P. C., Rimal, B., Patterson, A. D., Traxler, M. F., Pessotti, R. D. C., Alvarado-Villalobos, D., Tamayo-Castillo, G., Chaverri, P., Escudero-Leyva, E., Quiros-Guerrero, L. M., Bory, A. J., Joubert, J., Rutz, A., Wolfender, J. L., Allard, P. M., Sichert, A., Pontrelli, S., Pullman, B. S., Bandeira, N., Gerwick, W. H., Gindro, K., Massana-Codina, J., Wagner, B. C., Forchhammer, K., Petras, D., Aiosa, N., Garg, N., Liebeke, M., Bourceau, P., Kang, K. B., Gadhavi, H., de Carvalho, L. P. S., Silva dos Santos, M., Pérez-Lorente, A. I., Molina-Santiago, C., Romero, D., Franke, R., Brönstrup, M., Vera Ponce de León, A., Pope, P. B., La Rosa, S. L., La Barbera, G., Roager, H. M., Laursen, M. F., Hammerle, F., Siewert, B., Peintner, U., Licona-Cassani, C., Rodriguez-Orduña, L., Rampler, E., Hildebrand, F., Koellensperger, G., Schoeny, H., Hohenwallner, K., Panzenboeck, L., Gregor, R., O’Neill, E. C., Roxborough, E. T., Odoi, J., Bale, N. J., Ding, S., Sinninghe Damsté, J. S., Guan, X. L., Cui, J. J., Ju, K. S., Silva, D. B., Silva, F. M. R., da Silva, G. F., Koolen, H. H. F., Grundmann, C., Clement, J. A., Mohimani, H., Broders, K., McPhail, K. L., Ober-Singleton, S. E., Rath, C. M., McDonald, D., Knight, R., Wang, M. & Dorrestein, P. C., Feb 2024, In: Nature Microbiology. 9, 2, p. 336-345 10 p.

Research output: Contribution to journalArticlepeer-review

Changes in fecal lipidome after treatment with ivacaftor without changes in microbiome or bile acids

Bass, R., Tanes, C., Bittinger, K., Li, Y., Lee, H., Friedman, E. S., Koo, I., Patterson, A. D., Liu, Q., Wu, G. D. & Stallings, V. A., 2023, (Accepted/In press) In: Journal of Cystic Fibrosis.

Research output: Contribution to journalArticlepeer-review

Psyllium Fiber Protects Against Colitis Via Activation of Bile Acid Sensor Farnesoid X Receptor

Bretin, A., Zou, J., San Yeoh, B., Ngo, V. L., Winer, S., Winer, D. A., Reddivari, L., Pellizzon, M., Walters, W. A., Patterson, A. D., Ley, R., Chassaing, B., Vijay-Kumar, M. & Gewirtz, A. T., Jan 2023, In: CMGH. 15, 6, p. 1421-1442 22 p.

Research output: Contribution to journalArticlepeer-review

Molecular networking identifies an AHR-modulating benzothiazole from white button mushrooms (Agaricus bisporus)

Chen, X., Patterson, A. D., Perdew, G. H., Murray, I. A. & Kellogg, J. J., Jul 2023, In: Journal of Functional Foods. 106, 105602.

Research output: Contribution to journalArticlepeer-review

Bile acids and the gut microbiota: metabolic interactions and impacts on disease

Collins, S. L., Stine, J. G., Bisanz, J. E., Okafor, C. D. & Patterson, A. D., Apr 2023, In: Nature Reviews Microbiology. 21, 4, p. 236-247 12 p.

Research output: Contribution to journalReview articlepeer-review

Complex chemical signals dictate Ah receptor activation through the gut-lung axis

Dong, F., Murray, I. A., Annalora, A., Coslo, D. M., Desai, D., Gowda, K., Yang, J., Wang, D., Koo, I., Hao, F., Amin, S. G., Patterson, A. D., Marcus, C. & Perdew, G. H., Jul 1 2023, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37, 7, p. e23010

Research output: Contribution to journalArticlepeer-review

Endogenous Tryptophan-Derived Ah Receptor Ligands are Dissociated from CYP1A1/1B1-Dependent Negative-Feedback

Dong, F., Annalora, A. J., Murray, I. A., Tian, Y., Marcus, C. B., Patterson, A. D. & Perdew, G. H., Jan 1 2023, In: International Journal of Tryptophan Research. 16

Research output: Contribution to journalArticlepeer-review

Comparative urine metabolomics of mice treated with non-toxic and toxic oral doses of (−)-epigallocatechin-3-gallate

Hwang, S., Koo, I., Patterson, A. D. & Lambert, J. D., Oct 2 2023, In: Food and Function. 14, 20, p. 9434-9445 12 p.

Research output: Contribution to journalArticlepeer-review

Loss of selenoprotein W in murine macrophages alters the hierarchy of selenoprotein expression, redox tone, and mitochondrial functions during inflammation

Misra, S., Lee, T. J., Sebastian, A., McGuigan, J., Liao, C., Koo, I., Patterson, A. D., Rossi, R. M., Hall, M. A., Albert, I. & Prabhu, K. S., Feb 2023, In: Redox Biology. 59, 102571.

Research output: Contribution to journalArticlepeer-review