Andrew Patterson

Andrew Patterson is a professor of molecular toxicology and is the Scientific Director of Metabolomics. He and his students, postdocs, and collaborators focus on understanding the host-metabolite-microbiota communication network—specifically how the manipulation of gut microbiota by diet and/or xenobiotics impacts host metabolites (e.g., bile acids, short chain fatty acids), their metabolism, and how these co-metabolites interact with host nuclear/soluble receptors (e.g., farnesoid X receptor, aryl hydrocarbon receptor). The lab employs a variety of tools, including NMR- and mass spectrometry-based metabolomics, genomics, and conventional and gnotobiotic transgenic mice, to facilitate its study of these pathways and understand their impact on human health and disease.