Andrew Patterson is a professor of molecular toxicology and is the Scientific Director of Metabolomics. He and his students, postdocs, and collaborators focus on understanding the host-metabolite-microbiota communication network—specifically how the manipulation of gut microbiota by diet and/or xenobiotics impacts host metabolites (e.g., bile acids, short chain fatty acids), their metabolism, and how these co-metabolites interact with host nuclear/soluble receptors (e.g., farnesoid X receptor, aryl hydrocarbon receptor). The lab employs a variety of tools, including NMR- and mass spectrometry-based metabolomics, genomics, and conventional and gnotobiotic transgenic mice, to facilitate its study of these pathways and understand their impact on human health and disease.
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Projects
Recent Publications
Bezafibrate improves mitochondrial function, blood-brain barrier integrity, and social deficits in models of 22q11.2 deletion syndrome
Crockett, A. M., Vélez Colόn, M. C., Kebir, H., Smith, F. M., Iascone, D. M., Ciesielski, B., Koshkin, S., Patterson, A. D., Rossano, A. J., Sehgal, A., Anderson, S. A. & Alvarez, J. I., Aug 20 2025, In: Science Translational Medicine. 17, 812, eads2116.Research output: Contribution to journal › Article › peer-review
Maternal emulsifier consumption alters the offspring early-life microbiota and goblet cell function leading to long-lasting diseases susceptibility
Delaroque, C., Rytter, H., Bonazzi, E., Huillet, M., Ellero-Simatos, S., Chatonnat, E., Hao, F., Patterson, A. & Chassaing, B., Dec 2025, In: Nature communications. 16, 1, 6954.Research output: Contribution to journal › Article › peer-review
Effect of Varying Quantities of Lean Beef as Part of a Mediterranean-Style Dietary Pattern on Gut Microbiota and Plasma, Fecal, and Urinary Metabolites: A Randomized Crossover Controlled Feeding Trial
DiMattia, Z. S., Zhao, J., Hao, F., Koshkin, S., Bisanz, J. E., Patterson, A. D., Fleming, J. A., Kris-Etherton, P. M. & Petersen, K., Oct 7 2025, In: Journal of the American Heart Association. 14, 19, p. e041063Research output: Contribution to journal › Article › peer-review
Phytochemical-Mediated Ah Receptor Activity Is Dependent on Dietary Context
Dong, F., Annalora, A. J., Murray, I. A., Chakraborty, D., Coslo, D. M., Marcus, C., Patterson, A. D. & Perdew, G. H., Mar 2025, In: Nutrients. 17, 5, 876.Research output: Contribution to journal › Article › peer-review
Discovery of metabolites prevails amid in-source fragmentation
El Abiead, Y., Rutz, A., Zuffa, S., Amer, B., Xing, S., Brungs, C., Schmid, R., Correia, M. S. P., Caraballo-Rodriguez, A. M., Zarrinpar, A., Mannochio-Russo, H., Witting, M., Mohanty, I., Pluskal, T., Bittremieux, W., Knight, R., Patterson, A. D., van der Hooft, J. J. J., Böcker, S. & Dunn, W. B. & 6 others, , Mar 2025, In: Nature Metabolism. 7, 3, p. 435-437 3 p., 3832.Research output: Contribution to journal › Letter › peer-review
Fibroblast lipid metabolism through ACSL4 regulates epithelial sensitivity to ferroptosis in IBD
Huang, W., Zhang, Y., Das, N. K., Solanki, S., Jain, C., El-Derany, M. O., Koo, I., Bell, H. N., Aabed, N., Singhal, R., Castillo, C., Buscher, K., Ying, Y., Dimitroff, J., Sharma, A., Shi, J., Hogan, S. P., Dame, M. K., Higgins, P. D. R. & Colacino, J. A. & 7 others, , Jul 2025, In: Nature Metabolism. 7, 7, p. 1358-1374 17 p.Research output: Contribution to journal › Article › peer-review
Microbiota and metabolite-based prediction tool for colonic polyposis with and without a known genetic driver
Katona, B. W., Shukla, A., Hu, W., Nyul, T., Dudzik, C., Arvanitis, A., Clay, D., Dungan, M., Weber, M., Tu, V., Hao, F., Gan, S., Chau, L., Buchner, A. M., Falk, G. W., Jaffe, D. L., Ginsberg, G., Palmer, S. N., Zhan, X. & Patterson, A. D. & 2 others, , 2025, In: Gut microbes. 17, 1, 2474141.Research output: Contribution to journal › Article › peer-review
Differential hepatic activation of mouse and human peroxisome proliferator-activated receptor-α by perfluorohexane sulfonate
Khan, Y., Schmidt, A. M., Oldro, K. J., Zhu, X., Kramer, A. R., Hamilton, S. R., Bleil, K. O., Krisko, R. M., Zitzow, J. D., Tian, Y., Chang, S. C., Walter, V., Cohen, S. M., Gonzalez, F. J., Patterson, A. D. & Peters, J. M., May 1 2025, In: Toxicological Sciences. 205, 1, p. 47-52 6 p.Research output: Contribution to journal › Article › peer-review
Immunobiology of bile and cholangiocytes
Li, Y., Leung, P. S., Zhang, W., Zhang, S., Liu, Z., Kurth, M., Patterson, A. D., Gershwin, M. E. & Song, J., Feb 2025, In: Journal of Autoimmunity. 151, 103376.Research output: Contribution to journal › Review article › peer-review
Somatic mutations in IRE1α regulate keratinocyte migration and survival by differentially activating Rho GTPases
Mogre, S., Robinson, L., Sethia, K., Rimal, B., Son, J., Pacifico, C., Santy, L., Patterson, A. D. & Glick, A. B., Aug 2025, In: Journal of Cell Science. 138, 16, jcs263790.Research output: Contribution to journal › Article › peer-review
Almond snacking modulates gut microbiome and metabolome in association with improved cardiometabolic and inflammatory markers
Park, G., Johnson, K., Miller, K., Kadyan, S., Singar, S., Patoine, C., Hao, F., Lee, Y., Patterson, A. D., Arjmandi, B., Kris-Etherton, P. M., Berryman, C. E. & Nagpal, R., Dec 2025, In: npj Science of Food. 9, 1, 35.Research output: Contribution to journal › Article › peer-review
In vitro microbiota model recapitulates and predicts individualised sensitivity to dietary emulsifier
Rytter, H., Naimi, S., Wu, G., Lewis, J., Duquesnoy, M., Vigué, L., Tenaillon, O., Belda, E., Vazquez-Gomez, M., Touly, N., Arnone, D., Hao, F., Ley, R. E., Clément, K., Peyrin-Biroulet, L., Patterson, A. D., Gewirtz, A. T. & Chassaing, B., May 1 2025, In: Gut. 74, 5, p. 761-774 14 p.Research output: Contribution to journal › Article › peer-review
A designed synthetic microbiota provides insight to community function in Clostridioides difficile resistance
Tian, S., Kim, M. S., Zhao, J., Heber, K., Hao, F., Koslicki, D., Tian, S., Singh, V., Patterson, A. D. & Bisanz, J. E., Mar 12 2025, In: Cell Host and Microbe. 33, 3, p. 373-387.e9Research output: Contribution to journal › Article › peer-review
A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity
Alexander, M., Upadhyay, V., Rock, R., Ramirez, L., Trepka, K., Puchalska, P., Orellana, D., Ang, Q. Y., Whitty, C., Turnbaugh, J. A., Tian, Y., Dumlao, D., Nayak, R., Patterson, A., Newman, J. C., Crawford, P. A. & Turnbaugh, P. J., Nov 26 2024, In: Cell Reports. 43, 11, 114891.Research output: Contribution to journal › Article › peer-review
Modulation of Ceramide-Induced Apoptosis in Enteric Neurons by Aryl Hydrocarbon Receptor Signaling: Unveiling a New Pathway beyond ER Stress
Anitha, M., Kumar, S. M., Koo, I., Perdew, G. H., Srinivasan, S. & Patterson, A. D., Aug 2024, In: International journal of molecular sciences. 25, 16, 8581.Research output: Contribution to journal › Article › peer-review