Andrew Patterson

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IEE Research Themes
Affiliate Researcher
Titles and Affiliations
Professor, Veterinary and Biomedical Sciences

Research Summary

Research is focused on defining the role of PPARa in mitochondrial dysfunction associated with drug-induced hepatotoxicity. Perhaps the most critical role of PPARa is to modulate hepatic fatty acid catabolism. Research utilizes mouse models, traditional biochemistry and molecular biology techniques, as well as cutting-edge and highly sophisticated metabolomic approaches to understand the molecular mechanisms associated with PPARa activity.

In the News

Research Keywords

Recent Publications

Randomized Controlled-Feeding Study of Dietary Emulsifier Carboxymethylcellulose Reveals Detrimental Impacts on the Gut Microbiota and Metabolome

Chassaing, B., Compher, C., Bonhomme, B., Liu, Q., Tian, Y., Walters, W., Nessel, L., Delaroque, C., Hao, F., Gershuni, V., Chau, L., Ni, J., Bewtra, M., Albenberg, L., Bretin, A., McKeever, L., Ley, R. E., Patterson, A. D., Wu, G. D., Gewirtz, A. T., & 1 othersLewis, J. D., Mar 2022, In: Gastroenterology. 162, 3, p. 743-756 14 p.

Research output: Contribution to journalArticlepeer-review

Defective humoral immunity disrupts bile acid homeostasis which promotes inflammatory disease of the small bowel

Mohammed, A. D., Mohammed, Z., Roland, M. M., Chatzistamou, I., Jolly, A., Schoettmer, L. M., Arroyo, M., Kakar, K., Tian, Y., Patterson, A., Nagarkatti, M., Nagarkatti, P. & Kubinak, J. L., Dec 2022, In: Nature communications. 13, 1, 525.

Research output: Contribution to journalArticlepeer-review

Multi-Omics Strategies for Investigating the Microbiome in Toxicology Research

Morgan, E. W., Perdew, G. H. & Patterson, A. D., May 26 2022, In: Toxicological sciences : an official journal of the Society of Toxicology. 187, 2, p. 189-213 25 p.

Research output: Contribution to journalReview articlepeer-review

Metabolomic profiling of stool of two-year old children from the INSIGHT study reveals links between butyrate and child weight outcomes

Nandy, D., Craig, S. J. C., Cai, J., Tian, Y., Paul, I. M., Savage, J. S., Marini, M. E., Hohman, E. E., Reimherr, M. L., Patterson, A. D., Makova, K. D. & Chiaromonte, F., Jan 2022, In: Pediatric Obesity. 17, 1, e12833.

Research output: Contribution to journalArticlepeer-review

The role of mouse and human peroxisome proliferator-activated receptor-α in modulating the hepatic effects of perfluorooctane sulfonate in mice

Su, S., Billy, L. J., Chang, S., Gonzalez, F. J., Patterson, A. D. & Peters, J. M., Jan 15 2022, In: Toxicology. 465, 153056.

Research output: Contribution to journalArticlepeer-review

The east asian gut microbiome is distinct from colocalized white subjects and connected to metabolic health

Ang, Q. Y., Alba, D. L., Upadhyay, V., Bisanz, J. E., Cai, J., Lee, H. L., Barajas, E., Wei, G., Noecker, C., Patterson, A. D., Koliwad, S. K. & Turnbaugh, P. J., Oct 2021, In: eLife. 10, e70349.

Research output: Contribution to journalArticlepeer-review

The Pretreatment Gut Microbiome Is Associated With Lack of Response to Methotrexate in New-Onset Rheumatoid Arthritis

Artacho, A., Isaac, S., Nayak, R., Flor-Duro, A., Alexander, M., Koo, I., Manasson, J., Smith, P. B., Rosenthal, P., Homsi, Y., Gulko, P., Pons, J., Puchades-Carrasco, L., Izmirly, P., Patterson, A., Abramson, S. B., Pineda-Lucena, A., Turnbaugh, P. J., Ubeda, C. & Scher, J. U., Jun 2021, In: Arthritis and Rheumatology. 73, 6, p. 931-942 12 p.

Research output: Contribution to journalArticlepeer-review

Current Challenges and Recent Developments in Mass Spectrometry-Based Metabolomics

Collins, S. L., Koo, I., Peters, J. M., Smith, P. B. & Patterson, A. D., 2021, In: Annual Review of Analytical Chemistry. 14, p. 467-487 21 p.

Research output: Contribution to journalReview articlepeer-review

Reconstitution of the host holobiont in germ-free born male rats acutely increases bone growth and affects marrow cellular content

Czernik, P. J., Golonka, R. M., Chakraborty, S., Yeoh, B. S., Abokor, A. A., Saha, P., Yeo, J. Y., Mell, B., Cheng, X., Baroi, S., Tian, Y., Patterson, A. D., Joe, B., Vijay-Kumar, M. & Lecka-Czernik, B., Dec 2021, In: Physiological genomics. 53, 12, p. 518-533 16 p.

Research output: Contribution to journalArticlepeer-review

Exercise Training Reverses Gut Dysbiosis in Patients With Biopsy-Proven Nonalcoholic Steatohepatitis: A Proof of Concept Study

Hughes, A., Dahmus, J., Rivas, G., Hummer, B., Chen See, J. R., Wright, J. R., Lamendella, R., Schmitz, K. H., Sciamanna, C., Ruffin, M., Patterson, A. D., Loomba, R. & Stine, J. G., Aug 2021, In: Clinical Gastroenterology and Hepatology. 19, 8, p. 1723-1725 3 p.

Research output: Contribution to journalShort surveypeer-review

Selenium-dependent metabolic reprogramming during inflammation and resolution

Korwar, A. M., Hossain, A., Lee, T. J., Shay, A. E., Basrur, V., Conlon, K., Smith, P. B., Carlson, B. A., Salis, H. M., Patterson, A. D. & Prabhu, K. S., Jan 1 2021, In: Journal of Biological Chemistry. 296, 100410.

Research output: Contribution to journalArticlepeer-review

The aryl hydrocarbon receptor activates ceramide biosynthesis in mice contributing to hepatic lipogenesis

Liu, Q., Zhang, L., Allman, E. L., Hubbard, T. D., Murray, I. A., Hao, F., Tian, Y., Gui, W., Nichols, R. G., Smith, P. B., Anitha, M., Perdew, G. H. & Patterson, A. D., Jun 30 2021, In: Toxicology. 458, 152831.

Research output: Contribution to journalArticlepeer-review

Comparison of the effects of short-term feeding of sodium acetate and sodium bicarbonate on milk fat production

Matamoros, C., Cai, J., Patterson, A. D. & Harvatine, K. J., Jul 2021, In: Journal of dairy science. 104, 7, p. 7572-7582 11 p.

Research output: Contribution to journalArticlepeer-review

Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation

Nayak, R. R., Alexander, M., Deshpande, I., Stapleton-Gray, K., Rimal, B., Patterson, A. D., Ubeda, C., Scher, J. U. & Turnbaugh, P. J., Mar 10 2021, In: Cell Host and Microbe. 29, 3, p. 362-377.e11

Research output: Contribution to journalArticlepeer-review

Roux-en-Y Gastric Bypass Surgery Has Early Differential Effects on Bile Acids and the Levels of Complement Component 3 and Acylation-Stimulating Protein

Noel, O. F., Chu, X., Patterson, A. D., Edwards, M. A., Still, C. D. & Gerhard, G. S., Feb 2021, In: Obesity Surgery. 31, 2, p. 773-780 8 p.

Research output: Contribution to journalArticlepeer-review