Andrew Patterson

Affiliate Researcher
Titles and Affiliations
Professor, Veterinary and Biomedical Sciences

Research Summary

Research is focused on defining the role of PPARa in mitochondrial dysfunction associated with drug-induced hepatotoxicity. Perhaps the most critical role of PPARa is to modulate hepatic fatty acid catabolism. Research utilizes mouse models, traditional biochemistry and molecular biology techniques, as well as cutting-edge and highly sophisticated metabolomic approaches to understand the molecular mechanisms associated with PPARa activity.

In the News

Research Keywords

Projects

Recent Publications

Immune cell-intrinsic Ah receptor facilitates the expression of antimicrobial REG3G in the small intestine

Chakraborty, D., Coslo, D. M., Murray, I. A., Vijay, A., Patterson, A. D. & Perdew, G. H., Feb 29 2024, In: FASEB Journal. 38, 4, e23471.

Research output: Contribution to journalArticlepeer-review

Bile salt hydrolase catalyses formation of amine-conjugated bile acids

Rimal, B., Collins, S. L., Tanes, C. E., Rocha, E. R., Granda, M. A., Solanki, S., Hoque, N. J., Gentry, E. C., Koo, I., Reilly, E. R., Hao, F., Paudel, D., Singh, V., Yan, T., Kim, M. S., Bittinger, K., Zackular, J. P., Krausz, K. W., Desai, D., Amin, S., & 10 othersColeman, J. P., Shah, Y. M., Bisanz, J. E., Gonzalez, F. J., Vanden Heuvel, J. P., Wu, G. D., Zemel, B. S., Dorrestein, P. C., Weinert, E. E. & Patterson, A. D., Feb 22 2024, In: Nature. 626, 8000, p. 859-863 5 p.

Research output: Contribution to journalArticlepeer-review

Changes in fecal lipidome after treatment with ivacaftor without changes in microbiome or bile acids

Bass, R., Tanes, C., Bittinger, K., Li, Y., Lee, H., Friedman, E. S., Koo, I., Patterson, A. D., Liu, Q., Wu, G. D. & Stallings, V. A., 2023, (Accepted/In press) In: Journal of Cystic Fibrosis.

Research output: Contribution to journalArticlepeer-review

Psyllium Fiber Protects Against Colitis Via Activation of Bile Acid Sensor Farnesoid X Receptor

Bretin, A., Zou, J., San Yeoh, B., Ngo, V. L., Winer, S., Winer, D. A., Reddivari, L., Pellizzon, M., Walters, W. A., Patterson, A. D., Ley, R., Chassaing, B., Vijay-Kumar, M. & Gewirtz, A. T., Jan 2023, In: CMGH. 15, 6, p. 1421-1442 22 p.

Research output: Contribution to journalArticlepeer-review

Molecular networking identifies an AHR-modulating benzothiazole from white button mushrooms (Agaricus bisporus)

Chen, X., Patterson, A. D., Perdew, G. H., Murray, I. A. & Kellogg, J. J., Jul 2023, In: Journal of Functional Foods. 106, 105602.

Research output: Contribution to journalArticlepeer-review

Bile acids and the gut microbiota: metabolic interactions and impacts on disease

Collins, S. L., Stine, J. G., Bisanz, J. E., Okafor, C. D. & Patterson, A. D., Apr 2023, In: Nature Reviews Microbiology. 21, 4, p. 236-247 12 p.

Research output: Contribution to journalReview articlepeer-review

Complex chemical signals dictate Ah receptor activation through the gut-lung axis

Dong, F., Murray, I. A., Annalora, A., Coslo, D. M., Desai, D., Gowda, K., Yang, J., Wang, D., Koo, I., Hao, F., Amin, S. G., Patterson, A. D., Marcus, C. & Perdew, G. H., Jul 1 2023, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37, 7, p. e23010

Research output: Contribution to journalArticlepeer-review

Endogenous Tryptophan-Derived Ah Receptor Ligands are Dissociated from CYP1A1/1B1-Dependent Negative-Feedback

Dong, F., Annalora, A. J., Murray, I. A., Tian, Y., Marcus, C. B., Patterson, A. D. & Perdew, G. H., Jan 1 2023, In: International Journal of Tryptophan Research. 16

Research output: Contribution to journalArticlepeer-review

Comparative urine metabolomics of mice treated with non-toxic and toxic oral doses of (−)-epigallocatechin-3-gallate

Hwang, S., Koo, I., Patterson, A. D. & Lambert, J. D., Oct 2 2023, In: Food and Function. 14, 20, p. 9434-9445 12 p.

Research output: Contribution to journalArticlepeer-review

Loss of selenoprotein W in murine macrophages alters the hierarchy of selenoprotein expression, redox tone, and mitochondrial functions during inflammation

Misra, S., Lee, T. J., Sebastian, A., McGuigan, J., Liao, C., Koo, I., Patterson, A. D., Rossi, R. M., Hall, M. A., Albert, I. & Prabhu, K. S., Feb 2023, In: Redox Biology. 59, 102571.

Research output: Contribution to journalArticlepeer-review

Contribution of Circulating Host and Microbial Tryptophan Metabolites Toward Ah Receptor Activation

Morgan, E. W., Dong, F., Annalora, A. J., Murray, I. A., Wolfe, T., Erickson, R., Gowda, K., Amin, S. G., Petersen, K. S., Kris-Etherton, P. M., Marcus, C. B., Walk, S. T., Patterson, A. D. & Perdew, G. H., Jan 1 2023, In: International Journal of Tryptophan Research. 16

Research output: Contribution to journalArticlepeer-review

Induction of AHR Signaling in Response to the Indolimine Class of Microbial Stress Metabolites

Patel, D., Murray, I. A., Dong, F., Annalora, A. J., Gowda, K., Coslo, D. M., Krzeminski, J., Koo, I., Hao, F., Amin, S. G., Marcus, C. B., Patterson, A. D. & Perdew, G. H., Sep 2023, In: Metabolites. 13, 9, 985.

Research output: Contribution to journalArticlepeer-review

The Ah Receptor from Toxicity to Therapeutics: Report from the 5th AHR Meeting at Penn State University, USA, June 2022

Perdew, G. H., Esser, C., Snyder, M., Sherr, D. H., van den Bogaard, E. H., McGovern, K., Fernández-Salguero, P. M., Coumoul, X. & Patterson, A. D., Mar 2023, In: International journal of molecular sciences. 24, 6, 5550.

Research output: Contribution to journalArticlepeer-review

Profiling the human intestinal environment under physiological conditions

Shalon, D., Culver, R. N., Grembi, J. A., Folz, J., Treit, P. V., Shi, H., Rosenberger, F. A., Dethlefsen, L., Meng, X., Yaffe, E., Aranda-Díaz, A., Geyer, P. E., Mueller-Reif, J. B., Spencer, S., Patterson, A. D., Triadafilopoulos, G., Holmes, S. P., Mann, M., Fiehn, O., Relman, D. A., & 1 othersHuang, K. C., May 18 2023, In: Nature. 617, 7961, p. 581-591 11 p.

Research output: Contribution to journalArticlepeer-review

Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer

Sun, L., Zhang, Y., Cai, J., Rimal, B., Rocha, E. R., Coleman, J. P., Zhang, C., Nichols, R. G., Luo, Y., Kim, B., Chen, Y., Krausz, K. W., Harris, C. C., Patterson, A. D., Zhang, Z., Takahashi, S. & Gonzalez, F. J., Dec 2023, In: Nature communications. 14, 1, 755.

Research output: Contribution to journalArticlepeer-review