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Andrew Patterson

Profile Photo
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Email
adp117@psu.edu
Telephone
(814) 867-4565

322 Life Sciences Bldg
Shortlidge Road
University Park, PA 16802

Elsevier Pure Profile
IEE Research Themes
Health and the Environment
Affiliate Researcher
Titles and Affiliations
Professor, Veterinary and Biomedical Sciences

Research Summary

Research is focused on defining the role of PPARa in mitochondrial dysfunction associated with drug-induced hepatotoxicity. Perhaps the most critical role of PPARa is to modulate hepatic fatty acid catabolism. Research utilizes mouse models, traditional biochemistry and molecular biology techniques, as well as cutting-edge and highly sophisticated metabolomic approaches to understand the molecular mechanisms associated with PPARa activity.

In the News

Research Keywords

 These keywords and phrases come from the publications and other research output of this person. See other researchers related to these topics by clicking on any keyword.

Metabolomics
Gastrointestinal Microbiome
Microbiota
Pharmacological Metabolism
Aryl Hydrocarbon Receptors
Metabolic
Bile Acids And Salts
Mass Spectrometry
Liver
Diet
Non-alcoholic Fatty Liver Disease
Homeostasis
Metabolite
Muricholic Acid
Bile Acid
Peroxisome Proliferator-Activated Receptors
Hydrocarbon
Metabolome
Liquid Chromatography
Lipid Metabolism

Projects

Microscopic visualization of neurons
Linking Environmental Toxicants to Neurodegenerative Processes
Shapes symbolizing gut microbiota
Modeling the Host-Gut Microbiota Metabolic Interactions to Elucidate the Role of Perfluorooctane Sulfanate on Obesity Outcomes
Understanding the Impact of Persistent Environmental Chemicals on the Gut Microbiome

Recent Publications

Changes in fecal lipidome after treatment with ivacaftor without changes in microbiome or bile acids

Bass, R., Tanes, C., Bittinger, K., Li, Y., Lee, H., Friedman, E. S., Koo, I., Patterson, A. D., Liu, Q., Wu, G. D. & Stallings, V. A., May 2024, In: Journal of Cystic Fibrosis. 23, 3, p. 481-489 9 p.

Research output: Contribution to journal › Article › peer-review

Individualized microbiotas dictate the impact of dietary fiber on colitis sensitivity

Bonazzi, E., Bretin, A., Vigué, L., Hao, F., Patterson, A. D., Gewirtz, A. T. & Chassaing, B., Dec 2024, In: Microbiome. 12, 1, 5.

Research output: Contribution to journal › Article › peer-review

Immune cell-intrinsic Ah receptor facilitates the expression of antimicrobial REG3G in the small intestine

Chakraborty, D., Coslo, D. M., Murray, I. A., Vijay, A., Patterson, A. D. & Perdew, G. H., Feb 29 2024, In: FASEB Journal. 38, 4, e23471.

Research output: Contribution to journal › Article › peer-review

Human Intestinal Microbiome Determines Individualized Inflammatory Response to Dietary Emulsifier Carboxymethylcellulose Consumption

Daniel, N., Wu, G. D., Walters, W., Compher, C., Ni, J., Delaroque, C., Albenberg, L., Ley, R. E., Patterson, A. D., Lewis, J. D., Gewirtz, A. T. & Chassaing, B., Jan 2024, In: CMGH. 17, 2, p. 315-318 4 p.

Research output: Contribution to journal › Short survey › peer-review

Reverse metabolomics for the discovery of chemical structures from humans

Gentry, E. C., Collins, S. L., Panitchpakdi, M., Belda-Ferre, P., Stewart, A. K., Carrillo Terrazas, M., Lu, H. H., Zuffa, S., Yan, T., Avila-Pacheco, J., Plichta, D. R., Aron, A. T., Wang, M., Jarmusch, A. K., Hao, F., Syrkin-Nikolau, M., Vlamakis, H., Ananthakrishnan, A. N., Boland, B. S. & Hemperly, A. & 10 others, Vande Casteele, N., Gonzalez, F. J., Clish, C. B., Xavier, R. J., Chu, H., Baker, E. S., Patterson, A. D., Knight, R., Siegel, D. & Dorrestein, P. C., Feb 8 2024, In: Nature. 626, 7998, p. 419-426 8 p.

Research output: Contribution to journal › Article › peer-review

Sex Dimorphic Effects of Bile Acid Metabolism in Liver Cancer in Mice

Golonka, R. M., Yeoh, B. S., Saha, P., Tian, Y., Chiang, J. Y. L., Patterson, A. D., Gewirtz, A. T., Joe, B. & Kumar, M. V., Jan 2024, In: CMGH. 17, 5, p. 719-735 17 p.

Research output: Contribution to journal › Article › peer-review

Dietary carbohydrates regulate intestinal colonization and dissemination of Klebsiella pneumoniae

Hecht, A. L., Harling, L. C., Friedman, E. S., Tanes, C., Lee, J., Firrman, J., Hao, F., Tu, V., Liu, L. S., Patterson, A. D., Bittinger, K., Goulian, M. & Wu, G. D., May 1 2024, In: Journal of Clinical Investigation. 134, 9, e174726.

Research output: Contribution to journal › Article › peer-review

Magnetic field and ultrasound induced simultaneous wireless energy harvesting

Karan, S. K., Hosur, S., Kashani, Z., Leng, H., Vijay, A., Sriramdas, R., Wang, K., Poudel, B., Patterson, A. D., Kiani, M. & Priya, S., Jan 24 2024, In: Energy and Environmental Science. 17, 6, p. 2129-2144 16 p.

Research output: Contribution to journal › Article › peer-review

The underappreciated diversity of bile acid modifications

Mohanty, I., Mannochio-Russo, H., Schweer, J. V., El Abiead, Y., Bittremieux, W., Xing, S., Schmid, R., Zuffa, S., Vasquez, F., Muti, V. B., Zemlin, J., Tovar-Herrera, O. E., Moraïs, S., Desai, D., Amin, S., Koo, I., Turck, C. W., Mizrahi, I., Kris-Etherton, P. M. & Petersen, K. & 8 others, Fleming, J. A., Huan, T., Patterson, A. D., Siegel, D., Hagey, L. R., Wang, M., Aron, A. T. & Dorrestein, P. C., Mar 28 2024, In: Cell. 187, 7, p. 1801-1818.e20

Research output: Contribution to journal › Article › peer-review

Dietary fiber guar gum-induced shift in gut microbiota metabolism and intestinal immune activity enhances susceptibility to colonic inflammation

Paudel, D., Nair, D. V. T., Tian, S., Hao, F., Goand, U. K., Joseph, G., Prodes, E., Chai, Z., Robert, C. E. M., Chassaing, B., Patterson, A. D. & Singh, V., 2024, In: Gut microbes. 16, 1, 2341457.

Research output: Contribution to journal › Article › peer-review

Bile salt hydrolase catalyses formation of amine-conjugated bile acids

Rimal, B., Collins, S. L., Tanes, C. E., Rocha, E. R., Granda, M. A., Solanki, S., Hoque, N. J., Gentry, E. C., Koo, I., Reilly, E. R., Hao, F., Paudel, D., Singh, V., Yan, T., Kim, M. S., Bittinger, K., Zackular, J. P., Krausz, K. W., Desai, D. & Amin, S. & 10 others, Coleman, J. P., Shah, Y. M., Bisanz, J. E., Gonzalez, F. J., Vanden Heuvel, J. P., Wu, G. D., Zemel, B. S., Dorrestein, P. C., Weinert, E. E. & Patterson, A. D., Feb 22 2024, In: Nature. 626, 8000, p. 859-863 5 p.

Research output: Contribution to journal › Article › peer-review

Activation of Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) in Keratinocytes by Endogenous Fatty Acids

Zhu, B., Zhu, X., Borland, M. G., Ralph, D. H., Chiaro, C. R., Krausz, K. W., Ntambi, J. M., Glick, A. B., Patterson, A. D., Perdew, G. H., Gonzalez, F. J. & Peters, J. M., Jun 2024, In: Biomolecules. 14, 6, 606.

Research output: Contribution to journal › Article › peer-review

microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data

Zuffa, S., Schmid, R., Bauermeister, A., Paulo, P. W., Caraballo-Rodriguez, A. M., El Abiead, Y., Aron, A. T., Gentry, E. C., Zemlin, J., Meehan, M. J., Avalon, N. E., Cichewicz, R. H., Buzun, E., Terrazas, M. C., Hsu, C. Y., Oles, R., Ayala, A. V., Zhao, J., Chu, H. & Kuijpers, M. C. M. & 89 others, Jackrel, S. L., Tugizimana, F., Nephali, L. P., Dubery, I. A., Madala, N. E., Moreira, E. A., Costa-Lotufo, L. V., Lopes, N. P., Rezende-Teixeira, P., Jimenez, P. C., Rimal, B., Patterson, A. D., Traxler, M. F., Pessotti, R. D. C., Alvarado-Villalobos, D., Tamayo-Castillo, G., Chaverri, P., Escudero-Leyva, E., Quiros-Guerrero, L. M., Bory, A. J., Joubert, J., Rutz, A., Wolfender, J. L., Allard, P. M., Sichert, A., Pontrelli, S., Pullman, B. S., Bandeira, N., Gerwick, W. H., Gindro, K., Massana-Codina, J., Wagner, B. C., Forchhammer, K., Petras, D., Aiosa, N., Garg, N., Liebeke, M., Bourceau, P., Kang, K. B., Gadhavi, H., de Carvalho, L. P. S., Silva dos Santos, M., Pérez-Lorente, A. I., Molina-Santiago, C., Romero, D., Franke, R., Brönstrup, M., Vera Ponce de León, A., Pope, P. B., La Rosa, S. L., La Barbera, G., Roager, H. M., Laursen, M. F., Hammerle, F., Siewert, B., Peintner, U., Licona-Cassani, C., Rodriguez-Orduña, L., Rampler, E., Hildebrand, F., Koellensperger, G., Schoeny, H., Hohenwallner, K., Panzenboeck, L., Gregor, R., O’Neill, E. C., Roxborough, E. T., Odoi, J., Bale, N. J., Ding, S., Sinninghe Damsté, J. S., Guan, X. L., Cui, J. J., Ju, K. S., Silva, D. B., Silva, F. M. R., da Silva, G. F., Koolen, H. H. F., Grundmann, C., Clement, J. A., Mohimani, H., Broders, K., McPhail, K. L., Ober-Singleton, S. E., Rath, C. M., McDonald, D., Knight, R., Wang, M. & Dorrestein, P. C., Feb 2024, In: Nature Microbiology. 9, 2, p. 336-345 10 p.

Research output: Contribution to journal › Article › peer-review

Psyllium Fiber Protects Against Colitis Via Activation of Bile Acid Sensor Farnesoid X Receptor

Bretin, A., Zou, J., San Yeoh, B., Ngo, V. L., Winer, S., Winer, D. A., Reddivari, L., Pellizzon, M., Walters, W. A., Patterson, A. D., Ley, R., Chassaing, B., Vijay-Kumar, M. & Gewirtz, A. T., Jan 2023, In: CMGH. 15, 6, p. 1421-1442 22 p.

Research output: Contribution to journal › Article › peer-review

Molecular networking identifies an AHR-modulating benzothiazole from white button mushrooms (Agaricus bisporus)

Chen, X., Patterson, A. D., Perdew, G. H., Murray, I. A. & Kellogg, J. J., Jul 2023, In: Journal of Functional Foods. 106, 105602.

Research output: Contribution to journal › Article › peer-review