Research Summary
Research is focused on defining the role of PPARa in mitochondrial dysfunction associated with drug-induced hepatotoxicity. Perhaps the most critical role of PPARa is to modulate hepatic fatty acid catabolism. Research utilizes mouse models, traditional biochemistry and molecular biology techniques, as well as cutting-edge and highly sophisticated metabolomic approaches to understand the molecular mechanisms associated with PPARa activity.
In the News
Research Keywords
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Projects
Recent Publications
A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity
Alexander, M., Upadhyay, V., Rock, R., Ramirez, L., Trepka, K., Puchalska, P., Orellana, D., Ang, Q. Y., Whitty, C., Turnbaugh, J. A., Tian, Y., Dumlao, D., Nayak, R., Patterson, A., Newman, J. C., Crawford, P. A. & Turnbaugh, P. J., Nov 26 2024, In: Cell Reports. 43, 11, 114891.Research output: Contribution to journal › Article › peer-review
Modulation of Ceramide-Induced Apoptosis in Enteric Neurons by Aryl Hydrocarbon Receptor Signaling: Unveiling a New Pathway beyond ER Stress
Anitha, M., Kumar, S. M., Koo, I., Perdew, G. H., Srinivasan, S. & Patterson, A. D., Aug 2024, In: International journal of molecular sciences. 25, 16, 8581.Research output: Contribution to journal › Article › peer-review
Changes in fecal lipidome after treatment with ivacaftor without changes in microbiome or bile acids
Bass, R., Tanes, C., Bittinger, K., Li, Y., Lee, H., Friedman, E. S., Koo, I., Patterson, A. D., Liu, Q., Wu, G. D. & Stallings, V. A., May 2024, In: Journal of Cystic Fibrosis. 23, 3, p. 481-489 9 p.Research output: Contribution to journal › Article › peer-review
Individualized microbiotas dictate the impact of dietary fiber on colitis sensitivity
Bonazzi, E., Bretin, A., Vigué, L., Hao, F., Patterson, A. D., Gewirtz, A. T. & Chassaing, B., Dec 2024, In: Microbiome. 12, 1, 5.Research output: Contribution to journal › Article › peer-review
Immune cell-intrinsic Ah receptor facilitates the expression of antimicrobial REG3G in the small intestine
Chakraborty, D., Coslo, D. M., Murray, I. A., Vijay, A., Patterson, A. D. & Perdew, G. H., Feb 29 2024, In: FASEB Journal. 38, 4, e23471.Research output: Contribution to journal › Article › peer-review
Human Intestinal Microbiome Determines Individualized Inflammatory Response to Dietary Emulsifier Carboxymethylcellulose Consumption
Daniel, N., Wu, G. D., Walters, W., Compher, C., Ni, J., Delaroque, C., Albenberg, L., Ley, R. E., Patterson, A. D., Lewis, J. D., Gewirtz, A. T. & Chassaing, B., Jan 2024, In: CMGH. 17, 2, p. 315-318 4 p.Research output: Contribution to journal › Short survey › peer-review
Reverse metabolomics for the discovery of chemical structures from humans
Gentry, E. C., Collins, S. L., Panitchpakdi, M., Belda-Ferre, P., Stewart, A. K., Carrillo Terrazas, M., Lu, H. H., Zuffa, S., Yan, T., Avila-Pacheco, J., Plichta, D. R., Aron, A. T., Wang, M., Jarmusch, A. K., Hao, F., Syrkin-Nikolau, M., Vlamakis, H., Ananthakrishnan, A. N., Boland, B. S. & Hemperly, A. & 10 others, , Feb 8 2024, In: Nature. 626, 7998, p. 419-426 8 p.Research output: Contribution to journal › Article › peer-review
Sex Dimorphic Effects of Bile Acid Metabolism in Liver Cancer in Mice
Golonka, R. M., Yeoh, B. S., Saha, P., Tian, Y., Chiang, J. Y. L., Patterson, A. D., Gewirtz, A. T., Joe, B. & Kumar, M. V., Jan 2024, In: CMGH. 17, 5, p. 719-735 17 p.Research output: Contribution to journal › Article › peer-review
Dietary carbohydrates regulate intestinal colonization and dissemination of Klebsiella pneumoniae
Hecht, A. L., Harling, L. C., Friedman, E. S., Tanes, C., Lee, J., Firrman, J., Hao, F., Tu, V., Liu, L. S., Patterson, A. D., Bittinger, K., Goulian, M. & Wu, G. D., May 1 2024, In: Journal of Clinical Investigation. 134, 9, e174726.Research output: Contribution to journal › Article › peer-review
Magnetic field and ultrasound induced simultaneous wireless energy harvesting
Karan, S. K., Hosur, S., Kashani, Z., Leng, H., Vijay, A., Sriramdas, R., Wang, K., Poudel, B., Patterson, A. D., Kiani, M. & Priya, S., Jan 24 2024, In: Energy and Environmental Science. 17, 6, p. 2129-2144 16 p.Research output: Contribution to journal › Article › peer-review
Therapeutic targeting of differentiation-state dependent metabolic vulnerabilities in diffuse midline glioma
Mbah, N. E., Myers, A. L., Sajjakulnukit, P., Chung, C., Thompson, J. K., Hong, H. S., Giza, H., Dang, D., Nwosu, Z. C., Shan, M., Sweha, S. R., Maydan, D. D., Chen, B., Zhang, L., Magnuson, B., Zhu, Z., Radyk, M., Lavoie, B., Yadav, V. N. & Koo, I. & 7 others, , Dec 2024, In: Nature communications. 15, 1, 8983.Research output: Contribution to journal › Article › peer-review
The underappreciated diversity of bile acid modifications
Mohanty, I., Mannochio-Russo, H., Schweer, J. V., El Abiead, Y., Bittremieux, W., Xing, S., Schmid, R., Zuffa, S., Vasquez, F., Muti, V. B., Zemlin, J., Tovar-Herrera, O. E., Moraïs, S., Desai, D., Amin, S., Koo, I., Turck, C. W., Mizrahi, I., Kris-Etherton, P. M. & Petersen, K. & 8 others, , Mar 28 2024, In: Cell. 187, 7, p. 1801-1818.e20Research output: Contribution to journal › Article › peer-review
Chlorpyrifos modulates the mouse gut microbiota and metabolic activity
Nichols, R. G., Rimal, B., Hao, F., Peters, J. M., Davenport, E. R. & Patterson, A. D., Oct 2024, In: Environment international. 192, 109022.Research output: Contribution to journal › Article › peer-review
Hepatic stearoyl-CoA desaturase-1 deficiency induces fibrosis and hepatocellular carcinoma-related gene activation under a high carbohydrate low fat diet
Ntambi, J. N., Kalyesubula, M., Cootway, D., Lewis, S. A., Phang, Y. X., Liu, Z., O'Neill, L. M., Lefers, L., Huff, H., Miller, J. R., Pegkou Christofi, V., Anderson, E., Aljohani, A., Mutebi, F., Dutta, M., Patterson, A. & Ntambi, J. M., Oct 2024, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1869, 7, 159538.Research output: Contribution to journal › Article › peer-review
Dietary fiber guar gum-induced shift in gut microbiota metabolism and intestinal immune activity enhances susceptibility to colonic inflammation
Paudel, D., Nair, D. V. T., Tian, S., Hao, F., Goand, U. K., Joseph, G., Prodes, E., Chai, Z., Robert, C. E. M., Chassaing, B., Patterson, A. D. & Singh, V., 2024, In: Gut microbes. 16, 1, 2341457.Research output: Contribution to journal › Article › peer-review