Research Summary
Research is focused on defining the role of PPARa in mitochondrial dysfunction associated with drug-induced hepatotoxicity. Perhaps the most critical role of PPARa is to modulate hepatic fatty acid catabolism. Research utilizes mouse models, traditional biochemistry and molecular biology techniques, as well as cutting-edge and highly sophisticated metabolomic approaches to understand the molecular mechanisms associated with PPARa activity.
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Research Keywords
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Projects
Recent Publications
Immune cell-intrinsic Ah receptor facilitates the expression of antimicrobial REG3G in the small intestine
Chakraborty, D., Coslo, D. M., Murray, I. A., Vijay, A., Patterson, A. D. & Perdew, G. H., Feb 29 2024, In: FASEB Journal. 38, 4, e23471.Research output: Contribution to journal › Article › peer-review
Bile salt hydrolase catalyses formation of amine-conjugated bile acids
Rimal, B., Collins, S. L., Tanes, C. E., Rocha, E. R., Granda, M. A., Solanki, S., Hoque, N. J., Gentry, E. C., Koo, I., Reilly, E. R., Hao, F., Paudel, D., Singh, V., Yan, T., Kim, M. S., Bittinger, K., Zackular, J. P., Krausz, K. W., Desai, D., Amin, S., & 10 others , Feb 22 2024, In: Nature. 626, 8000, p. 859-863 5 p.Research output: Contribution to journal › Article › peer-review
Changes in fecal lipidome after treatment with ivacaftor without changes in microbiome or bile acids
Bass, R., Tanes, C., Bittinger, K., Li, Y., Lee, H., Friedman, E. S., Koo, I., Patterson, A. D., Liu, Q., Wu, G. D. & Stallings, V. A., 2023, (Accepted/In press) In: Journal of Cystic Fibrosis.Research output: Contribution to journal › Article › peer-review
Psyllium Fiber Protects Against Colitis Via Activation of Bile Acid Sensor Farnesoid X Receptor
Bretin, A., Zou, J., San Yeoh, B., Ngo, V. L., Winer, S., Winer, D. A., Reddivari, L., Pellizzon, M., Walters, W. A., Patterson, A. D., Ley, R., Chassaing, B., Vijay-Kumar, M. & Gewirtz, A. T., Jan 2023, In: CMGH. 15, 6, p. 1421-1442 22 p.Research output: Contribution to journal › Article › peer-review
Molecular networking identifies an AHR-modulating benzothiazole from white button mushrooms (Agaricus bisporus)
Chen, X., Patterson, A. D., Perdew, G. H., Murray, I. A. & Kellogg, J. J., Jul 2023, In: Journal of Functional Foods. 106, 105602.Research output: Contribution to journal › Article › peer-review
Bile acids and the gut microbiota: metabolic interactions and impacts on disease
Collins, S. L., Stine, J. G., Bisanz, J. E., Okafor, C. D. & Patterson, A. D., Apr 2023, In: Nature Reviews Microbiology. 21, 4, p. 236-247 12 p.Research output: Contribution to journal › Review article › peer-review
Complex chemical signals dictate Ah receptor activation through the gut-lung axis
Dong, F., Murray, I. A., Annalora, A., Coslo, D. M., Desai, D., Gowda, K., Yang, J., Wang, D., Koo, I., Hao, F., Amin, S. G., Patterson, A. D., Marcus, C. & Perdew, G. H., Jul 1 2023, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37, 7, p. e23010Research output: Contribution to journal › Article › peer-review
Endogenous Tryptophan-Derived Ah Receptor Ligands are Dissociated from CYP1A1/1B1-Dependent Negative-Feedback
Dong, F., Annalora, A. J., Murray, I. A., Tian, Y., Marcus, C. B., Patterson, A. D. & Perdew, G. H., Jan 1 2023, In: International Journal of Tryptophan Research. 16Research output: Contribution to journal › Article › peer-review
Comparative urine metabolomics of mice treated with non-toxic and toxic oral doses of (−)-epigallocatechin-3-gallate
Hwang, S., Koo, I., Patterson, A. D. & Lambert, J. D., Oct 2 2023, In: Food and Function. 14, 20, p. 9434-9445 12 p.Research output: Contribution to journal › Article › peer-review
Loss of selenoprotein W in murine macrophages alters the hierarchy of selenoprotein expression, redox tone, and mitochondrial functions during inflammation
Misra, S., Lee, T. J., Sebastian, A., McGuigan, J., Liao, C., Koo, I., Patterson, A. D., Rossi, R. M., Hall, M. A., Albert, I. & Prabhu, K. S., Feb 2023, In: Redox Biology. 59, 102571.Research output: Contribution to journal › Article › peer-review
Contribution of Circulating Host and Microbial Tryptophan Metabolites Toward Ah Receptor Activation
Morgan, E. W., Dong, F., Annalora, A. J., Murray, I. A., Wolfe, T., Erickson, R., Gowda, K., Amin, S. G., Petersen, K. S., Kris-Etherton, P. M., Marcus, C. B., Walk, S. T., Patterson, A. D. & Perdew, G. H., Jan 1 2023, In: International Journal of Tryptophan Research. 16Research output: Contribution to journal › Article › peer-review
Induction of AHR Signaling in Response to the Indolimine Class of Microbial Stress Metabolites
Patel, D., Murray, I. A., Dong, F., Annalora, A. J., Gowda, K., Coslo, D. M., Krzeminski, J., Koo, I., Hao, F., Amin, S. G., Marcus, C. B., Patterson, A. D. & Perdew, G. H., Sep 2023, In: Metabolites. 13, 9, 985.Research output: Contribution to journal › Article › peer-review
The Ah Receptor from Toxicity to Therapeutics: Report from the 5th AHR Meeting at Penn State University, USA, June 2022
Perdew, G. H., Esser, C., Snyder, M., Sherr, D. H., van den Bogaard, E. H., McGovern, K., Fernández-Salguero, P. M., Coumoul, X. & Patterson, A. D., Mar 2023, In: International journal of molecular sciences. 24, 6, 5550.Research output: Contribution to journal › Article › peer-review
Profiling the human intestinal environment under physiological conditions
Shalon, D., Culver, R. N., Grembi, J. A., Folz, J., Treit, P. V., Shi, H., Rosenberger, F. A., Dethlefsen, L., Meng, X., Yaffe, E., Aranda-Díaz, A., Geyer, P. E., Mueller-Reif, J. B., Spencer, S., Patterson, A. D., Triadafilopoulos, G., Holmes, S. P., Mann, M., Fiehn, O., Relman, D. A., & 1 others , May 18 2023, In: Nature. 617, 7961, p. 581-591 11 p.Research output: Contribution to journal › Article › peer-review
Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer
Sun, L., Zhang, Y., Cai, J., Rimal, B., Rocha, E. R., Coleman, J. P., Zhang, C., Nichols, R. G., Luo, Y., Kim, B., Chen, Y., Krausz, K. W., Harris, C. C., Patterson, A. D., Zhang, Z., Takahashi, S. & Gonzalez, F. J., Dec 2023, In: Nature communications. 14, 1, 755.Research output: Contribution to journal › Article › peer-review