Andrew Patterson

Affiliate Researcher
Titles and Affiliations
Professor, Veterinary and Biomedical Sciences

Research Summary

Research is focused on defining the role of PPARa in mitochondrial dysfunction associated with drug-induced hepatotoxicity. Perhaps the most critical role of PPARa is to modulate hepatic fatty acid catabolism. Research utilizes mouse models, traditional biochemistry and molecular biology techniques, as well as cutting-edge and highly sophisticated metabolomic approaches to understand the molecular mechanisms associated with PPARa activity.

In the News

Research Keywords

Projects

Recent Publications

Bile acid conjugation deficiency causes hypercholanemia, hyperphagia, islet dysfunction, and gut dysbiosis in mice

Alrehaili, B. D., Lee, M., Takahashi, S., Novak, R., Rimal, B., Boehme, S., Trammell, S. A. J., Grevengoed, T. J., Kumar, D., Alnouti, Y., Chiti, K., Wang, X., Patterson, A. D., Chiang, J. Y. L., Gonzalez, F. J. & Lee, Y. K., Oct 2022, In: Hepatology Communications. 6, 10, p. 2765-2780 16 p.

Research output: Contribution to journalArticlepeer-review

Effect of 2-hydroxy-4-(methylthio)butanoate (HMTBa) on milk fat, rumen environment and biohydrogenation, and rumen protozoa in lactating cows fed diets with increased risk for milk fat depression

Baldin, M., Garcia, D., Zanton, G. I., Hao, F., Patterson, A. D. & Harvatine, K. J., Sep 2022, In: Journal of dairy science. 105, 9, p. 7446-7461 16 p.

Research output: Contribution to journalArticlepeer-review

Bile acid metabolism and signaling, the microbiota, and metabolic disease

Cai, J., Rimal, B., Jiang, C., Chiang, J. Y. L. & Patterson, A. D., Sep 1 2022, In: Pharmacology and Therapeutics, Part A: Chemotherapy, Toxicology and. 237, p. 108238 1 p.

Research output: Contribution to journalReview articlepeer-review

Randomized Controlled-Feeding Study of Dietary Emulsifier Carboxymethylcellulose Reveals Detrimental Impacts on the Gut Microbiota and Metabolome

Chassaing, B., Compher, C., Bonhomme, B., Liu, Q., Tian, Y., Walters, W., Nessel, L., Delaroque, C., Hao, F., Gershuni, V., Chau, L., Ni, J., Bewtra, M., Albenberg, L., Bretin, A., McKeever, L., Ley, R. E., Patterson, A. D., Wu, G. D., Gewirtz, A. T., & 1 othersLewis, J. D., Mar 2022, In: Gastroenterology. 162, 3, p. 743-756 14 p.

Research output: Contribution to journalArticlepeer-review

Bile acids and the gut microbiota: metabolic interactions and impacts on disease

Collins, S. L., Stine, J. G., Bisanz, J. E., Okafor, C. D. & Patterson, A. D., 2022, (Accepted/In press) In: Nature Reviews Microbiology.

Research output: Contribution to journalReview articlepeer-review

AHR is a master regulator of diverse pathways in endogenous metabolism

Granados, J. C., Falah, K., Koo, I., Morgan, E. W., Perdew, G. H., Patterson, A. D., Jamshidi, N. & Nigam, S. K., Dec 2022, In: Scientific reports. 12, 1, 16625.

Research output: Contribution to journalArticlepeer-review

Defective humoral immunity disrupts bile acid homeostasis which promotes inflammatory disease of the small bowel

Mohammed, A. D., Mohammed, Z., Roland, M. M., Chatzistamou, I., Jolly, A., Schoettmer, L. M., Arroyo, M., Kakar, K., Tian, Y., Patterson, A., Nagarkatti, M., Nagarkatti, P. & Kubinak, J. L., Dec 2022, In: Nature communications. 13, 1, 525.

Research output: Contribution to journalArticlepeer-review

Multi-Omics Strategies for Investigating the Microbiome in Toxicology Research

Morgan, E. W., Perdew, G. H. & Patterson, A. D., May 26 2022, In: Toxicological sciences : an official journal of the Society of Toxicology. 187, 2, p. 189-213 25 p.

Research output: Contribution to journalReview articlepeer-review

Metabolomic profiling of stool of two-year old children from the INSIGHT study reveals links between butyrate and child weight outcomes

Nandy, D., Craig, S. J. C., Cai, J., Tian, Y., Paul, I. M., Savage, J. S., Marini, M. E., Hohman, E. E., Reimherr, M. L., Patterson, A. D., Makova, K. D. & Chiaromonte, F., Jan 2022, In: Pediatric Obesity. 17, 1, e12833.

Research output: Contribution to journalArticlepeer-review

Genetic differences in nicotine sensitivity and metabolism in C57BL/6J and NOD/ShiLtJ mouse strains

Seemiller, L. R., Goldberg, L. R., Smith, P. B., Dennis, J., Patterson, A. D. & Gould, T. J., Dec 15 2022, In: Neuropharmacology. 221, 109279.

Research output: Contribution to journalArticlepeer-review

The role of mouse and human peroxisome proliferator-activated receptor-α in modulating the hepatic effects of perfluorooctane sulfonate in mice

Su, S., Billy, L. J., Chang, S., Gonzalez, F. J., Patterson, A. D. & Peters, J. M., Jan 15 2022, In: Toxicology. 465, 153056.

Research output: Contribution to journalArticlepeer-review

Early Life Polychlorinated Biphenyl 126 Exposure Disrupts Gut Microbiota and Metabolic Homeostasis in Mice Fed with High-Fat Diet in Adulthood

Tian, Y., Rimal, B., Gui, W., Koo, I., Smith, P. B., Yokoyama, S. & Patterson, A. D., Oct 2022, In: Metabolites. 12, 10, 894.

Research output: Contribution to journalArticlepeer-review

Early Life Short-Term Exposure to Polychlorinated Biphenyl 126 in Mice Leads to Metabolic Dysfunction and Microbiota Changes in Adulthood

Tian, Y., Rimal, B., Gui, W., Koo, I., Yokoyama, S., Perdew, G. H. & Patterson, A. D., Aug 2022, In: International journal of molecular sciences. 23, 15, 8220.

Research output: Contribution to journalArticlepeer-review

The east asian gut microbiome is distinct from colocalized white subjects and connected to metabolic health

Ang, Q. Y., Alba, D. L., Upadhyay, V., Bisanz, J. E., Cai, J., Lee, H. L., Barajas, E., Wei, G., Noecker, C., Patterson, A. D., Koliwad, S. K. & Turnbaugh, P. J., Oct 2021, In: eLife. 10, e70349.

Research output: Contribution to journalArticlepeer-review

The Pretreatment Gut Microbiome Is Associated With Lack of Response to Methotrexate in New-Onset Rheumatoid Arthritis

Artacho, A., Isaac, S., Nayak, R., Flor-Duro, A., Alexander, M., Koo, I., Manasson, J., Smith, P. B., Rosenthal, P., Homsi, Y., Gulko, P., Pons, J., Puchades-Carrasco, L., Izmirly, P., Patterson, A., Abramson, S. B., Pineda-Lucena, A., Turnbaugh, P. J., Ubeda, C. & Scher, J. U., Jun 2021, In: Arthritis and Rheumatology. 73, 6, p. 931-942 12 p.

Research output: Contribution to journalArticlepeer-review