Andrew Patterson

Affiliate Researcher
Titles and Affiliations
Professor, Veterinary and Biomedical Sciences

Andrew Patterson is a professor of molecular toxicology and is the Scientific Director of Metabolomics. He and his students, postdocs, and collaborators focus on understanding the host-metabolite-microbiota communication network—specifically how the manipulation of gut microbiota by diet and/or xenobiotics impacts host metabolites (e.g., bile acids, short chain fatty acids), their metabolism, and how these co-metabolites interact with host nuclear/soluble receptors (e.g., farnesoid X receptor, aryl hydrocarbon receptor). The lab employs a variety of tools, including NMR- and mass spectrometry-based metabolomics, genomics, and conventional and gnotobiotic transgenic mice, to facilitate its study of these pathways and understand their impact on human health and disease. 

In the News

Research Keywords

Projects

Recent Publications

Phytochemical-Mediated Ah Receptor Activity Is Dependent on Dietary Context

Dong, F., Annalora, A. J., Murray, I. A., Chakraborty, D., Coslo, D. M., Marcus, C., Patterson, A. D. & Perdew, G. H., Mar 2025, In: Nutrients. 17, 5, 876.

Research output: Contribution to journalArticlepeer-review

Discovery of metabolites prevails amid in-source fragmentation

El Abiead, Y., Rutz, A., Zuffa, S., Amer, B., Xing, S., Brungs, C., Schmid, R., Correia, M. S. P., Caraballo-Rodriguez, A. M., Zarrinpar, A., Mannochio-Russo, H., Witting, M., Mohanty, I., Pluskal, T., Bittremieux, W., Knight, R., Patterson, A. D., van der Hooft, J. J. J., Böcker, S. & Dunn, W. B. & 6 others, Linington, R. G., Wishart, D. S., Wolfender, J. L., Fiehn, O., Zamboni, N. & Dorrestein, P. C., Mar 2025, In: Nature Metabolism. 7, 3, p. 435-437 3 p., 3832.

Research output: Contribution to journalLetterpeer-review

Microbiota and metabolite-based prediction tool for colonic polyposis with and without a known genetic driver

Katona, B. W., Shukla, A., Hu, W., Nyul, T., Dudzik, C., Arvanitis, A., Clay, D., Dungan, M., Weber, M., Tu, V., Hao, F., Gan, S., Chau, L., Buchner, A. M., Falk, G. W., Jaffe, D. L., Ginsberg, G., Palmer, S. N., Zhan, X. & Patterson, A. D. & 2 others, Bittinger, K. & Ni, J., 2025, In: Gut microbes. 17, 1, 2474141.

Research output: Contribution to journalArticlepeer-review

Immunobiology of bile and cholangiocytes

Li, Y., Leung, P. S., Zhang, W., Zhang, S., Liu, Z., Kurth, M., Patterson, A. D., Gershwin, M. E. & Song, J., Feb 2025, In: Journal of Autoimmunity. 151, 103376.

Research output: Contribution to journalReview articlepeer-review

Almond snacking modulates gut microbiome and metabolome in association with improved cardiometabolic and inflammatory markers

Park, G., Johnson, K., Miller, K., Kadyan, S., Singar, S., Patoine, C., Hao, F., Lee, Y., Patterson, A. D., Arjmandi, B., Kris-Etherton, P. M., Berryman, C. E. & Nagpal, R., Dec 2025, In: npj Science of Food. 9, 1, 35.

Research output: Contribution to journalArticlepeer-review

In vitro microbiota model recapitulates and predicts individualised sensitivity to dietary emulsifier

Rytter, H., Naimi, S., Wu, G., Lewis, J., Duquesnoy, M., Vigué, L., Tenaillon, O., Belda, E., Vazquez-Gomez, M., Touly, N., Arnone, D., Hao, F., Ley, R. E., Clément, K., Peyrin-Biroulet, L., Patterson, A. D., Gewirtz, A. T. & Chassaing, B., May 1 2025, In: Gut. 74, 5, p. 761-774 14 p.

Research output: Contribution to journalArticlepeer-review

A designed synthetic microbiota provides insight to community function in Clostridioides difficile resistance

Tian, S., Kim, M. S., Zhao, J., Heber, K., Hao, F., Koslicki, D., Tian, S., Singh, V., Patterson, A. D. & Bisanz, J. E., Mar 12 2025, In: Cell Host and Microbe. 33, 3, p. 373-387.e9

Research output: Contribution to journalArticlepeer-review

A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity

Alexander, M., Upadhyay, V., Rock, R., Ramirez, L., Trepka, K., Puchalska, P., Orellana, D., Ang, Q. Y., Whitty, C., Turnbaugh, J. A., Tian, Y., Dumlao, D., Nayak, R., Patterson, A., Newman, J. C., Crawford, P. A. & Turnbaugh, P. J., Nov 26 2024, In: Cell Reports. 43, 11, 114891.

Research output: Contribution to journalArticlepeer-review

Modulation of Ceramide-Induced Apoptosis in Enteric Neurons by Aryl Hydrocarbon Receptor Signaling: Unveiling a New Pathway beyond ER Stress

Anitha, M., Kumar, S. M., Koo, I., Perdew, G. H., Srinivasan, S. & Patterson, A. D., Aug 2024, In: International journal of molecular sciences. 25, 16, 8581.

Research output: Contribution to journalArticlepeer-review

Changes in fecal lipidome after treatment with ivacaftor without changes in microbiome or bile acids

Bass, R., Tanes, C., Bittinger, K., Li, Y., Lee, H., Friedman, E. S., Koo, I., Patterson, A. D., Liu, Q., Wu, G. D. & Stallings, V. A., May 2024, In: Journal of Cystic Fibrosis. 23, 3, p. 481-489 9 p.

Research output: Contribution to journalArticlepeer-review

Individualized microbiotas dictate the impact of dietary fiber on colitis sensitivity

Bonazzi, E., Bretin, A., Vigué, L., Hao, F., Patterson, A. D., Gewirtz, A. T. & Chassaing, B., Dec 2024, In: Microbiome. 12, 1, 5.

Research output: Contribution to journalArticlepeer-review

Immune cell-intrinsic Ah receptor facilitates the expression of antimicrobial REG3G in the small intestine

Chakraborty, D., Coslo, D. M., Murray, I. A., Vijay, A., Patterson, A. D. & Perdew, G. H., Feb 29 2024, In: FASEB Journal. 38, 4, e23471.

Research output: Contribution to journalArticlepeer-review

Human Intestinal Microbiome Determines Individualized Inflammatory Response to Dietary Emulsifier Carboxymethylcellulose Consumption

Daniel, N., Wu, G. D., Walters, W., Compher, C., Ni, J., Delaroque, C., Albenberg, L., Ley, R. E., Patterson, A. D., Lewis, J. D., Gewirtz, A. T. & Chassaing, B., Jan 2024, In: CMGH. 17, 2, p. 315-318 4 p.

Research output: Contribution to journalShort surveypeer-review

Reverse metabolomics for the discovery of chemical structures from humans

Gentry, E. C., Collins, S. L., Panitchpakdi, M., Belda-Ferre, P., Stewart, A. K., Carrillo Terrazas, M., Lu, H. H., Zuffa, S., Yan, T., Avila-Pacheco, J., Plichta, D. R., Aron, A. T., Wang, M., Jarmusch, A. K., Hao, F., Syrkin-Nikolau, M., Vlamakis, H., Ananthakrishnan, A. N., Boland, B. S. & Hemperly, A. & 10 others, Vande Casteele, N., Gonzalez, F. J., Clish, C. B., Xavier, R. J., Chu, H., Baker, E. S., Patterson, A. D., Knight, R., Siegel, D. & Dorrestein, P. C., Feb 8 2024, In: Nature. 626, 7998, p. 419-426 8 p.

Research output: Contribution to journalArticlepeer-review

Sex Dimorphic Effects of Bile Acid Metabolism in Liver Cancer in Mice

Golonka, R. M., Yeoh, B. S., Saha, P., Tian, Y., Chiang, J. Y. L., Patterson, A. D., Gewirtz, A. T., Joe, B. & Kumar, M. V., Jan 2024, In: CMGH. 17, 5, p. 719-735 17 p.

Research output: Contribution to journalArticlepeer-review