The Dynamic Dance of Molecules in Solution
Neela Yennawar | Huck Institutes of the life Sciences
The need for accurate biophysical description of macromolecules, multimerization, flexibility, dynamics and binding in their solution state has gained importance in various fields, including biology, chemistry, biophysics, biochemistry, structural biology, drug discovery, and antibody drugs. Multiple complimentary analyses need to be performed for success with high resolution structural methods such as X-ray crystallography and cryo-EM. Recent unique capabilities at the Huck X-ray crystallography and biological calorimetry facilities focus on a combination of tools for studying solution state structures: size-exclusion chromatography (SEC), multi-angle light scattering (MALS), dynamic light scattering (DLS), small-angle X-ray scattering (SAXS), analytical ultracentrifugation (AUC), isothermal calorimetry (ITC), differential scanning calorimetry (DSC) and circular dichroism spectroscopy (CD).
Opportunities in Quantum Sensors Applications
Daniel Lopez | EECS and the Nanofabrication Laboratory
Quantum sensors are expected to enable new capabilities in many fields by offering enhanced performance, smaller size, weight and power, and novel modalities for sensing. I will provide a brief overview of the main areas where quantum sensing is expected to have a significant impact and describe some of the work currently under development at PSU.