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To contain the COVID-19 spread, one of the non-pharmaceutical interventions is physical (social) distancing. An interactive web-based mapping platform, which provides up-to-date mobility and close contact information using large-scale anonymized mobile phone location data in the US, was developed and maintained by the GeoDS Lab at UW-Madison. Using the multiscale human mobility origin-to-destination (OD) flow data, a novel mobility-augmented compartmental epidemic model was further developed to help analyze the COVID-19 spread dynamics at multiple geographical scales (e.g., state, county, and neighborhood), inform public health policy, and deepen our understanding of human behavior under the unprecedented public health crisis.