Sandeep Prabhu

IEE Faculty Member
Titles and Affiliations
Department Head and Professor, Veterinary and Biomedical Sciences

Research Summary

Research interests include regulation of gene expression by oxidative, glycative and hypertonic stressors; molecular mechanisms underlying the antioxidant role of selenium; lipid biochemistry-prostaglandins, leukotrienes and oxidized fatty acids as nuclear receptor ligands. Current research areas include regulation of pro-inflammatory gene expression by oxidative stress-dependent mechanisms and the role of selenium in macrophages, isolation and characterization of endogenous ligands for the peroxisome proliferator-activated receptors (PPARs), and targeting of leukemia stem cells.

In the News

Research Keywords

Recent Publications

Loss of selenoprotein W in murine macrophages alters the hierarchy of selenoprotein expression, redox tone, and mitochondrial functions during inflammation

Misra, S., Lee, T. J., Sebastian, A., McGuigan, J., Liao, C., Koo, I., Patterson, A. D., Rossi, R. M., Hall, M. A., Albert, I. & Prabhu, K. S., Feb 2023, In: Redox Biology. 59, 102571.

Research output: Contribution to journalArticlepeer-review

Selenoprotein W Ameliorates Experimental Colitis and Promotes Intestinal Epithelial Repair

Nettleford, S. K., Liao, C., Short, S. P., Rossi, R. M., Singh, V. & Prabhu, K. S., Apr 2023, In: Antioxidants. 12, 4, 850.

Research output: Contribution to journalArticlepeer-review

Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice

Qian, F., Arner, B. E., Nettleford, S. K., Paulson, R. F. & Prabhu, K. S., Jan 2023, In: Journal of Visualized Experiments. 2023, 191, e64834.

Research output: Contribution to journalArticlepeer-review

Correlation of Serum Selenium in Asthma Patients with Severity of the Disorder

Girdhar, N., Kansal, H., Garg, K., Sharma, S., Prabhu, K. S., Chopra, V., Tinkov, A. A., Skalny, A. V. & Prakash, N. T., Dec 2022, In: Biological Trace Element Research. 200, 12, p. 4949-4954 6 p.

Research output: Contribution to journalArticlepeer-review

A novel clinically relevant graft-versus-leukemia model in humanized mice

Jia, B., Zhao, C., Bayerl, M., Shike, H., Claxton, D. F., Ehmann, W. C., Mineishi, S., Schell, T. D., Zheng, P., Zhang, Y., Shultz, L. D., Prabhu, K. S., Paulson, R. F. & Zheng, H., Feb 2022, In: Journal of Leukocyte Biology. 111, 2, p. 427-437 11 p.

Research output: Contribution to journalArticlepeer-review

The role of selenoproteins in neutrophils during inflammation

Lee, T. J., Nettleford, S. K., McGlynn, A., Carlson, B. A., Kirimanjeswara, G. S. & Prabhu, K. S., Dec 15 2022, In: Archives of Biochemistry and Biophysics. 732, 109452.

Research output: Contribution to journalArticlepeer-review

Interleukin-4 treatment reduces leukemia burden in acute myeloid leukemia

Qian, F., Arner, B. E., Kelly, K. M., Annageldiyev, C., Sharma, A., Claxton, D. F., Paulson, R. F. & Prabhu, K. S., May 2022, In: FASEB Journal. 36, 5, e22328.

Research output: Contribution to journalArticlepeer-review

Selenium-dependent metabolic reprogramming during inflammation and resolution

Korwar, A. M., Hossain, A., Lee, T. J., Shay, A. E., Basrur, V., Conlon, K., Smith, P. B., Carlson, B. A., Salis, H. M., Patterson, A. D. & Prabhu, K. S., Jan 1 2021, In: Journal of Biological Chemistry. 296, 100410.

Research output: Contribution to journalArticlepeer-review

Macrophage Selenoproteins Restrict Intracellular Replication of Francisella tularensis and Are Essential for Host Immunity

Markley, R. L., Restori, K. H., Katkere, B., Sumner, S. E., Nicol, M. J., Tyryshkina, A., Nettleford, S. K., Williamson, D. R., Place, D. E., Dewan, K. K., Shay, A. E., Carlson, B. A., Girirajan, S., Prabhu, K. S. & Kirimanjeswara, G. S., Oct 29 2021, In: Frontiers in immunology. 12, 701341.

Research output: Contribution to journalArticlepeer-review

Epo receptor signaling in macrophages alters the splenic niche to promote erythroid differentiation

Chen, Y., Xiang, J., Qian, F., Diwakar, B. T., Ruan, B., Hao, S., Sandeep Prabhu, K. & Paulson, R. F., Jul 9 2020, In: Blood. 136, 2, p. 235-246 12 p.

Research output: Contribution to journalArticlepeer-review

The Essential Role of Selenoproteins in the Resolution of Citrobacter rodentium-Induced Intestinal Inflammation

Nettleford, S. K., Zhao, L., Qian, F., Herold, M., Arner, B., Desai, D., Amin, S., Xiong, N., Singh, V., Carlson, B. A. & Prabhu, K. S., Jul 8 2020, In: Frontiers in Nutrition. 7, 96.

Research output: Contribution to journalArticlepeer-review

p38 MAP-kinase inhibitor protects against platelet-activating factor-induced death in mice

Abhilasha, K. V., Sumanth, M. S., Chaithra, V. H., Jacob, S. P., Thyagarajan, A., Sahu, R. P., Rajaiah, R., Prabhu, K. S., Kemparaju, K., Travers, J. B., Chen, C. H. & Marathe, G. K., Nov 1 2019, In: Free Radical Biology and Medicine. 143, p. 275-287 13 p.

Research output: Contribution to journalArticlepeer-review

Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C

Bennett, L. F., Liao, C., Quickel, M. D., Yeoh, B. S., Vijay-Kumar, M., Hankey-Giblin, P., Prabhu, K. S. & Paulson, R. F., Sep 10 2019, In: Science signaling. 12, 598, eaap7336.

Research output: Contribution to journalArticlepeer-review

Special Issue of “Optimal Selenium Status and Selenoproteins in Health”

Cheng, W. H. & Prabhu, K. S., Nov 1 2019, In: Biological Trace Element Research. 192, 1

Research output: Contribution to journalEditorialpeer-review

Selenium-rich maize modulates the expression of prostaglandin genes in lipopolysaccharide-stimulated RAW264.7 macrophages

Dhanjal, N. I., Sharma, S., Skalny, A. V., Skalnaya, M. G., Ajsuvakova, O. P., Tinkov, A. A., Zhang, F., Guo, X., Prabhu, K. S. & Tejo Prakash, N., May 2019, In: Food and Function. 10, 5, p. 2839-2846 8 p.

Research output: Contribution to journalArticlepeer-review