Research Summary
Research interests include regulation of gene expression by oxidative, glycative and hypertonic stressors; molecular mechanisms underlying the antioxidant role of selenium; lipid biochemistry-prostaglandins, leukotrienes and oxidized fatty acids as nuclear receptor ligands. Current research areas include regulation of pro-inflammatory gene expression by oxidative stress-dependent mechanisms and the role of selenium in macrophages, isolation and characterization of endogenous ligands for the peroxisome proliferator-activated receptors (PPARs), and targeting of leukemia stem cells.
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Recent Publications
Loss of selenoprotein W in murine macrophages alters the hierarchy of selenoprotein expression, redox tone, and mitochondrial functions during inflammation
Misra, S., Lee, T. J., Sebastian, A., McGuigan, J., Liao, C., Koo, I., Patterson, A. D., Rossi, R. M., Hall, M. A., Albert, I. & Prabhu, K. S., Feb 2023, In: Redox Biology. 59, 102571.Research output: Contribution to journal ⺠Article ⺠peer-review
Selenoprotein W Ameliorates Experimental Colitis and Promotes Intestinal Epithelial Repair
Nettleford, S. K., Liao, C., Short, S. P., Rossi, R. M., Singh, V. & Prabhu, K. S., Apr 2023, In: Antioxidants. 12, 4, 850.Research output: Contribution to journal ⺠Article ⺠peer-review
Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice
Qian, F., Arner, B. E., Nettleford, S. K., Paulson, R. F. & Prabhu, K. S., Jan 2023, In: Journal of Visualized Experiments. 2023, 191, e64834.Research output: Contribution to journal ⺠Article ⺠peer-review
Correlation of Serum Selenium in Asthma Patients with Severity of the Disorder
Girdhar, N., Kansal, H., Garg, K., Sharma, S., Prabhu, K. S., Chopra, V., Tinkov, A. A., Skalny, A. V. & Prakash, N. T., Dec 2022, In: Biological Trace Element Research. 200, 12, p. 4949-4954 6 p.Research output: Contribution to journal ⺠Article ⺠peer-review
A novel clinically relevant graft-versus-leukemia model in humanized mice
Jia, B., Zhao, C., Bayerl, M., Shike, H., Claxton, D. F., Ehmann, W. C., Mineishi, S., Schell, T. D., Zheng, P., Zhang, Y., Shultz, L. D., Prabhu, K. S., Paulson, R. F. & Zheng, H., Feb 2022, In: Journal of Leukocyte Biology. 111, 2, p. 427-437 11 p.Research output: Contribution to journal ⺠Article ⺠peer-review
The role of selenoproteins in neutrophils during inflammation
Lee, T. J., Nettleford, S. K., McGlynn, A., Carlson, B. A., Kirimanjeswara, G. S. & Prabhu, K. S., Dec 15 2022, In: Archives of Biochemistry and Biophysics. 732, 109452.Research output: Contribution to journal ⺠Article ⺠peer-review
Interleukin-4 treatment reduces leukemia burden in acute myeloid leukemia
Qian, F., Arner, B. E., Kelly, K. M., Annageldiyev, C., Sharma, A., Claxton, D. F., Paulson, R. F. & Prabhu, K. S., May 2022, In: FASEB Journal. 36, 5, e22328.Research output: Contribution to journal ⺠Article ⺠peer-review
Selenium-dependent metabolic reprogramming during inflammation and resolution
Korwar, A. M., Hossain, A., Lee, T. J., Shay, A. E., Basrur, V., Conlon, K., Smith, P. B., Carlson, B. A., Salis, H. M., Patterson, A. D. & Prabhu, K. S., Jan 1 2021, In: Journal of Biological Chemistry. 296, 100410.Research output: Contribution to journal ⺠Article ⺠peer-review
Macrophage Selenoproteins Restrict Intracellular Replication of Francisella tularensis and Are Essential for Host Immunity
Markley, R. L., Restori, K. H., Katkere, B., Sumner, S. E., Nicol, M. J., Tyryshkina, A., Nettleford, S. K., Williamson, D. R., Place, D. E., Dewan, K. K., Shay, A. E., Carlson, B. A., Girirajan, S., Prabhu, K. S. & Kirimanjeswara, G. S., Oct 29 2021, In: Frontiers in immunology. 12, 701341.Research output: Contribution to journal ⺠Article ⺠peer-review
Epo receptor signaling in macrophages alters the splenic niche to promote erythroid differentiation
Chen, Y., Xiang, J., Qian, F., Diwakar, B. T., Ruan, B., Hao, S., Sandeep Prabhu, K. & Paulson, R. F., Jul 9 2020, In: Blood. 136, 2, p. 235-246 12 p.Research output: Contribution to journal ⺠Article ⺠peer-review
The Essential Role of Selenoproteins in the Resolution of Citrobacter rodentium-Induced Intestinal Inflammation
Nettleford, S. K., Zhao, L., Qian, F., Herold, M., Arner, B., Desai, D., Amin, S., Xiong, N., Singh, V., Carlson, B. A. & Prabhu, K. S., Jul 8 2020, In: Frontiers in Nutrition. 7, 96.Research output: Contribution to journal ⺠Article ⺠peer-review
p38 MAP-kinase inhibitor protects against platelet-activating factor-induced death in mice
Abhilasha, K. V., Sumanth, M. S., Chaithra, V. H., Jacob, S. P., Thyagarajan, A., Sahu, R. P., Rajaiah, R., Prabhu, K. S., Kemparaju, K., Travers, J. B., Chen, C. H. & Marathe, G. K., Nov 1 2019, In: Free Radical Biology and Medicine. 143, p. 275-287 13 p.Research output: Contribution to journal ⺠Article ⺠peer-review
Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C
Bennett, L. F., Liao, C., Quickel, M. D., Yeoh, B. S., Vijay-Kumar, M., Hankey-Giblin, P., Prabhu, K. S. & Paulson, R. F., Sep 10 2019, In: Science signaling. 12, 598, eaap7336.Research output: Contribution to journal ⺠Article ⺠peer-review
Special Issue of âOptimal Selenium Status and Selenoproteins in Healthâ
Cheng, W. H. & Prabhu, K. S., Nov 1 2019, In: Biological Trace Element Research. 192, 1Research output: Contribution to journal ⺠Editorial ⺠peer-review
Selenium-rich maize modulates the expression of prostaglandin genes in lipopolysaccharide-stimulated RAW264.7 macrophages
Dhanjal, N. I., Sharma, S., Skalny, A. V., Skalnaya, M. G., Ajsuvakova, O. P., Tinkov, A. A., Zhang, F., Guo, X., Prabhu, K. S. & Tejo Prakash, N., May 2019, In: Food and Function. 10, 5, p. 2839-2846 8 p.Research output: Contribution to journal ⺠Article ⺠peer-review