Sandeep Prabhu

Cofunded Faculty Member
Titles and Affiliations
Department Head and Professor, Veterinary and Biomedical Sciences

Research Summary

Research interests include regulation of gene expression by oxidative, glycative and hypertonic stressors; molecular mechanisms underlying the antioxidant role of selenium; lipid biochemistry-prostaglandins, leukotrienes and oxidized fatty acids as nuclear receptor ligands. Current research areas include regulation of pro-inflammatory gene expression by oxidative stress-dependent mechanisms and the role of selenium in macrophages, isolation and characterization of endogenous ligands for the peroxisome proliferator-activated receptors (PPARs), and targeting of leukemia stem cells.

In the News

Research Keywords

Recent Publications

Correlation of Serum Selenium in Asthma Patients with Severity of the Disorder

Girdhar, N., Kansal, H., Garg, K., Sharma, S., Prabhu, K. S., Chopra, V., Tinkov, A. A., Skalny, A. V. & Prakash, N. T., Dec 2022, In: Biological Trace Element Research. 200, 12, p. 4949-4954 6 p.

Research output: Contribution to journalArticlepeer-review

A novel clinically relevant graft-versus-leukemia model in humanized mice

Jia, B., Zhao, C., Bayerl, M., Shike, H., Claxton, D. F., Ehmann, W. C., Mineishi, S., Schell, T. D., Zheng, P., Zhang, Y., Shultz, L. D., Prabhu, K. S., Paulson, R. F. & Zheng, H., Feb 2022, In: Journal of Leukocyte Biology. 111, 2, p. 427-437 11 p.

Research output: Contribution to journalArticlepeer-review

Selenium-dependent metabolic reprogramming during inflammation and resolution

Korwar, A. M., Hossain, A., Lee, T. J., Shay, A. E., Basrur, V., Conlon, K., Smith, P. B., Carlson, B. A., Salis, H. M., Patterson, A. D. & Prabhu, K. S., Jan 1 2021, In: Journal of Biological Chemistry. 296, 100410.

Research output: Contribution to journalArticlepeer-review

Macrophage Selenoproteins Restrict Intracellular Replication of Francisella tularensis and Are Essential for Host Immunity

Markley, R. L., Restori, K. H., Katkere, B., Sumner, S. E., Nicol, M. J., Tyryshkina, A., Nettleford, S. K., Williamson, D. R., Place, D. E., Dewan, K. K., Shay, A. E., Carlson, B. A., Girirajan, S., Prabhu, K. S. & Kirimanjeswara, G. S., Oct 29 2021, In: Frontiers in immunology. 12, 701341.

Research output: Contribution to journalArticlepeer-review

Epo receptor signaling in macrophages alters the splenic niche to promote erythroid differentiation

Chen, Y., Xiang, J., Qian, F., Diwakar, B. T., Ruan, B., Hao, S., Sandeep Prabhu, K. & Paulson, R. F., Jul 9 2020, In: Blood. 136, 2, p. 235-246 12 p.

Research output: Contribution to journalArticlepeer-review

The Essential Role of Selenoproteins in the Resolution of Citrobacter rodentium-Induced Intestinal Inflammation

Nettleford, S. K., Zhao, L., Qian, F., Herold, M., Arner, B., Desai, D., Amin, S., Xiong, N., Singh, V., Carlson, B. A. & Prabhu, K. S., Jul 8 2020, In: Frontiers in Nutrition. 7, 96.

Research output: Contribution to journalArticlepeer-review

p38 MAP-kinase inhibitor protects against platelet-activating factor-induced death in mice

Abhilasha, K. V., Sumanth, M. S., Chaithra, V. H., Jacob, S. P., Thyagarajan, A., Sahu, R. P., Rajaiah, R., Prabhu, K. S., Kemparaju, K., Travers, J. B., Chen, C. H. & Marathe, G. K., Nov 1 2019, In: Free Radical Biology and Medicine. 143, p. 275-287 13 p.

Research output: Contribution to journalArticlepeer-review

Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C

Bennett, L. F., Liao, C., Quickel, M. D., Yeoh, B. S., Vijay-Kumar, M., Hankey-Giblin, P., Prabhu, K. S. & Paulson, R. F., Sep 10 2019, In: Science signaling. 12, 598, eaap7336.

Research output: Contribution to journalArticlepeer-review

Special Issue of “Optimal Selenium Status and Selenoproteins in Health”

Cheng, W. H. & Prabhu, K. S., Nov 1 2019, In: Biological Trace Element Research. 192, 1

Research output: Contribution to journalEditorialpeer-review

Selenium-rich maize modulates the expression of prostaglandin genes in lipopolysaccharide-stimulated RAW264.7 macrophages

Dhanjal, N. I., Sharma, S., Skalny, A. V., Skalnaya, M. G., Ajsuvakova, O. P., Tinkov, A. A., Zhang, F., Guo, X., Prabhu, K. S. & Tejo Prakash, N., May 2019, In: Food and Function. 10, 5, p. 2839-2846 8 p.

Research output: Contribution to journalArticlepeer-review

Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-αB activation in murine macrophages via changes in intracellular calcium

Diwakar, B. T., Yoast, R., Nettleford, S., Qian, F., Lee, T. J., Berry, S., Huffnagle, I., Rossi, R. M., Trebak, M., Paulson, R. F. & Prabhu, K. S., Nov 1 2019, In: FASEB Journal. 33, 11, p. 12838-12852 15 p.

Research output: Contribution to journalArticlepeer-review

Downregulation of CD73 associates with T cell exhaustion in AML patients

Kong, Y., Jia, B., Zhao, C., Claxton, D. F., Sharma, A., Annageldiyev, C., Fotos, J. S., Zeng, H., Paulson, R. F., Prabhu, K. S. & Zheng, H., Apr 24 2019, In: Journal of Hematology and Oncology. 12, 1, 40.

Research output: Contribution to journalArticlepeer-review

Selenoproteome Identification in Inflamed Murine Primary Bone Marrow-Derived Macrophages by Nano-LC Orbitrap Fusion Tribrid Mass Spectrometry

Korwar, A. M., Shay, A. E., Basrur, V., Conlon, K. & Prabhu, K. S., Jul 15 2019, In: Journal of the American Society for Mass Spectrometry. 30, 7, p. 1276-1283 8 p.

Research output: Contribution to journalArticlepeer-review

Selenium and selenoproteins in prostanoid metabolism and immunity

Qian, F., Misra, S. & Prabhu, K. S., Nov 2 2019, In: Critical Reviews in Biochemistry and Molecular Biology. 54, 6, p. 484-516 33 p.

Research output: Contribution to journalReview articlepeer-review

Acute phase protein, α – 1- acid glycoprotein (AGP-1), has differential effects on TLR-2 and TLR-4 mediated responses

Sumanth, M. S., Abhilasha, K. V., Jacob, S. P., Chaithra, V. H., Basrur, V., Willard, B., McIntyre, T. M., Prabhu, K. S. & Marathe, G. K., Sep 2019, In: Immunobiology. 224, 5, p. 672-680 9 p.

Research output: Contribution to journalArticlepeer-review