Philip Bevilacqua

Affiliate Researcher
Titles and Affiliations
Professor, Chemistry

Research Summary

Biological chemistry of RNA, characterization of RNA catalysis and folding, characterization of the RNA-dependent regulation of human viral response and RNA folding in plants as a response to environmental stress.

In the News

Research Keywords

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Recent Publications

Regulatory Mechanisms through RNA Conformational Switching and Dynamics

Bevilacqua, P. C. & Tolbert, B. S., Sep 30 2022, In: Journal of Molecular Biology. 434, 18, 167794.

Research output: Contribution to journalEditorialpeer-review

RNA multimerization as an organizing force for liquid–liquid phase separation

Bevilacqua, P. C., Williams, A. M., Chou, H. L. & Assmann, S. M., Jan 2022, In: RNA. 28, 1, p. 16-26 11 p.

Research output: Contribution to journalArticlepeer-review

Phase-specific RNA accumulation and duplex thermodynamics in multiphase coacervate models for membraneless organelles

Choi, S., Meyer, M. C. O., Bevilacqua, P. C. & Keating, C. D., 2022, (Accepted/In press) In: Nature Chemistry.

Research output: Contribution to journalArticlepeer-review

Experimental demonstration and pan-structurome prediction of climate-associated riboSNitches in Arabidopsis

Ferrero-Serrano, Á., Sylvia, M. M., Forstmeier, P. C., Olson, A. J., Ware, D., Bevilacqua, P. C. & Assmann, S. M., Dec 2022, In: Genome biology. 23, 1, 101.

Research output: Contribution to journalArticlepeer-review

Upstream Flanking Sequence Assists Folding of an RNA Thermometer

Jolley, E. A., Bormes, K. M. & Bevilacqua, P. C., Sep 30 2022, In: Journal of Molecular Biology. 434, 18, 167786.

Research output: Contribution to journalArticlepeer-review

Biological solution conditions and flanking sequence modulate LLPS of RNA G-quadruplex structures

Williams, A. M., Dickson, T. M., Lagoa-Miguel, C. A. & Bevilacqua, P. C., Sep 1 2022, In: RNA (New York, N.Y.). 28, 9, p. 1197-1209 13 p.

Research output: Contribution to journalArticlepeer-review

Genome-wide analysis of the in vivo tRNA structurome reveals RNA structural and modification dynamics under heat stress

Yamagami, R., Sieg, J. P., Assmann, S. M. & Bevilacqua, P. C., Jun 21 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 25, e2201237119.

Research output: Contribution to journalArticlepeer-review

RNA sequence and structure control assembly and function of RNA condensates

Poudyal, R. R., Sieg, J. P., Portz, B., Keating, C. D. & Bevilacqua, P. C., Dec 1 2021, In: RNA (New York, N.Y.). 27, 12, p. 1589-1601 13 p.

Research output: Contribution to journalArticlepeer-review

Investigation of the pKa of the nucleophilic O2' of the hairpin ribozyme

Veenis, A. J., Li, P., Soudackov, A. V., Hammes-Schiffer, S. & Bevilacqua, P. C., Nov 4 2021, In: Journal of Physical Chemistry B. 125, 43, p. 11869-11883 15 p.

Research output: Contribution to journalArticlepeer-review

Long Tracts of Guanines Drive Aggregation of RNA G-Quadruplexes in the Presence of Spermine

Williams, A. M., Poudyal, R. R. & Bevilacqua, P. C., Sep 14 2021, In: Biochemistry. 60, 36, p. 2715-2726 12 p.

Research output: Contribution to journalArticlepeer-review

Functional Roles of Chelated Magnesium Ions in RNA Folding and Function

Yamagami, R., Sieg, J. P. & Bevilacqua, P. C., Aug 10 2021, In: Biochemistry. 60, 31, p. 2374-2386 13 p.

Research output: Contribution to journalReview articlepeer-review

Efficient construction of long DNA duplexes with internal non-Watson-Crick motifs and modifications

Zheng, X. & Bevilacqua, P. C., Jan 1 2021, In: Nucleic acids research. 29, 2, e6.

Research output: Contribution to journalArticlepeer-review

Prebiotically-relevant low polyion multivalency can improve functionality of membraneless compartments

Cakmak, F. P., Choi, S., Meyer, M. C. O., Bevilacqua, P. C. & Keating, C. D., Dec 2020, In: Nature communications. 11, 1, 5949.

Research output: Contribution to journalArticlepeer-review

Csra-mediated translational activation of ymda expression in escherichia coli

Renda, A., Poly, S., Lai, Y. J., Pannuri, A., Yakhnin, H., Potts, A. H., Bevilacqua, P. C., Romeo, T. & Babitzke, P., Sep 1 2020, In: mBio. 11, 5, p. 1-12 12 p., e00849-20.

Research output: Contribution to journalArticlepeer-review

Structure-seq2 probing of RNA structure upon amino acid starvation reveals both known and novel RNA switches in Bacillus subtilis

Ritchey, L. E., Tack, D. C., Yakhnin, H., Jolley, E. A., Assmann, S. M., Bevilacqua, P. C. & Babitzke, P., Oct 2020, In: RNA. 26, 10, p. 1431-1447 17 p.

Research output: Contribution to journalArticlepeer-review