Research Summary
Role of receptor tyrosine kinases in normal physiology and disease progression and the downstream signals that mediate these responses in vitro and in vivo.
Research Keywords
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Recent Publications
Metabolic profiling reveals aggravated non-alcoholic steatohepatitis in high-fat high-cholesterol diet-fed apolipoprotein e-deficient mice lacking ron receptor signaling
Allen, J. N., Dey, A., Cai, J., Zhang, J., Tian, Y., Kennett, M., Ma, Y., Liang, T. J., Patterson, A. D. & Hankey-Giblin, P. A., Aug 2020, In: Metabolites. 10, 8, p. 1-24 24 p., 326.Research output: Contribution to journal › Article › peer-review
Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C
Bennett, L. F., Liao, C., Quickel, M. D., Yeoh, B. S., Vijay-Kumar, M., Hankey-Giblin, P., Prabhu, K. S. & Paulson, R. F., Sep 10 2019, In: Science signaling. 12, 598, eaap7336.Research output: Contribution to journal › Article › peer-review
Gab2 and Gab3 redundantly suppress colitis by modulating macrophage and CD8+ T-cell activation
Wang, Z., Vaughan, T. Y., Zhu, W., Chen, Y., Fu, G., Medrzycki, M., Nishio, H., Bunting, S. T., Hankey-Giblin, P. A., Nusrat, A., Parkos, C. A., Wang, D., Wen, R. & Bunting, K. D., 2019, In: Frontiers in immunology. 10, MAR, 486.Research output: Contribution to journal › Article › peer-review
Ron Receptor Signaling Ameliorates Hepatic Fibrosis in a Diet-Induced Nonalcoholic Steatohepatitis Mouse Model
Allen, J., Zhang, J., Quickel, M. D., Kennett, M., Patterson, A. D. & Hankey-Giblin, P. A., Sep 7 2018, In: Journal of Proteome Research. 17, 9, p. 3268-3280 13 p.Research output: Contribution to journal › Article › peer-review
Insights into macrophage heterogeneity and cytokine-induced neuroinflammation in major depressive disorder
Dey, A. & Giblin, P. A. H., Sep 2018, In: Pharmaceuticals. 11, 3, 64.Research output: Contribution to journal › Review article › peer-review
Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease
Dey, A., Allen, J. N., Fraser, J. W., Snyder, L. M., Tian, Y., Zhang, L., Paulson, R. F., Patterson, A., Cantorna, M. T. & Hankey-Giblin, P. A., Mar 19 2018, In: Frontiers in immunology. 9, MAR, 513.Research output: Contribution to journal › Article › peer-review
Isolation, characterization, and purification of macrophages from tissues affected by obesity-related inflammation
Allen, J. N., Dey, A., Nissly, R., Fraser, J., Yu, S., Balandaram, G., Peters, J. M. & Hankey-Giblin, P. A., Apr 3 2017, In: Journal of Visualized Experiments. 2017, 122, e55445.Research output: Contribution to journal › Article › peer-review
Reduced competitive repopulation capacity of multipotential hematopoietic stem cells in the bone marrow of friend virus-infected Fv2-resistant mice
Epperly, M. W., Zhang, X., Fisher, R., Hou, W., Franicola, D., Shields, D., Quickel, M., Hankey-Giblin, P., Wang, H. & Greenberger, J. S., May 1 2017, In: In Vivo. 31, 3, p. 313-320 8 p.Research output: Contribution to journal › Article › peer-review
Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria
Feaga, H. A., Quickel, M. D., Hankey-Giblin, P. A. & Keiler, K. C., Mar 2016, In: PLoS genetics. 12, 3, e1005964.Research output: Contribution to journal › Article › peer-review
The ron receptor tyrosine kinase regulates macrophage heterogeneity and plays a protective role in diet-induced obesity, atherosclerosis, and hepatosteatosis
Yu, S., Allen, J. N., Dey, A., Zhang, L., Balandaram, G., Kennett, M. J., Xia, M., Xiong, N., Peters, J. M., Patterson, A. & Hankey-Giblin, P. A., Jul 1 2016, In: Journal of Immunology. 197, 1, p. 256-265 10 p.Research output: Contribution to journal › Article › peer-review
Ontogeny and polarization of macrophages in inflammation: Blood monocytes versus tissue macrophages
Dey, A., Allen, J. & Hankey-Giblin, P. A., 2015, In: Frontiers in immunology. 6, JAN, 00683.Research output: Contribution to journal › Review article › peer-review
Autoinhibition of the Ron receptor tyrosine kinase by the juxtamembrane domain
Wang, X., Yennawar, N. & Hankey, P. A., Apr 16 2014, In: Cell Communication and Signaling. 12, 1, 28.Research output: Contribution to journal › Article › peer-review
The RON receptor tyrosine kinase: A key regulator of inflammation and cancer progression
Wang, X. & Giblin, P. H., Oct 15 2013, In: Critical Reviews in Immunology. 33, 6, p. 549-574 26 p.Research output: Contribution to journal › Article › peer-review
Regulation of alternative macrophage activation in the liver following acetaminophen intoxication by stem cell-derived tyrosine kinase
Gardner, C. R., Hankey, P., Mishin, V., Francis, M., Yu, S., Laskin, J. D. & Laskin, D. L., Jul 15 2012, In: Toxicology and Applied Pharmacology. 262, 2, p. 139-148 10 p.Research output: Contribution to journal › Article › peer-review
Self-renewal of leukemia stem cells in friend virus-induced erythroleukemia requires proviral insertional activation of spi1 and hedgehog signaling but not mutation of p53
Hegde, S., Hankey, P. & Paulson, R. F., Feb 2012, In: STEM CELLS. 30, 2, p. 121-130 10 p.Research output: Contribution to journal › Article › peer-review