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Professor, Biochemistry & Molecular Biology
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Recent Publications
Hexosamine biosynthesis disruption impairs GPI production and arrests Plasmodium falciparum growth at schizont stages
Alberione, M. P., Avalos-Padilla, Y., Rangel, G. W., Ramírez, M., Romero-Uruñuela, T., Fenollar, À., Ortega-Barrionuevo, J., Crispim, M., Smith, T. K., Llinás, M. & Izquierdo, L., Jul 2025, In: PLoS pathogens. 21, 7 July, e1012832.Research output: Contribution to journal › Article › peer-review
Structural characterization of the ACDC domain from ApiAP2 proteins, a potential molecular target against apicomplexan parasites
Le Berre, M., Tubiana, T., Waldner, P. R., Lazar, N., Li De La Sierra-Gallay, I., Santos, J. M., Llinás, M. & Nessler, S., Jan 1 2025, In: Acta Crystallographica Section D: Structural Biology. 81, p. 38-48 11 p.Research output: Contribution to journal › Article › peer-review
Metabolite profiling of Artemisia afra and Artemisia annua extracts reveals divergent effects on Plasmodium falciparum
Mamede, L., Rangel, G. W., Shinyuy, L. M., Boussif, N., Herent, M. F., Govaerts, B., Jansen, O., Ledoux, A., De Tullio, P., Quetin-Leclercq, J., Llinás, M. & Frédérich, M., Jan 2025, In: Phytomedicine. 136, 156361.Research output: Contribution to journal › Article › peer-review
Multiple, redundant carboxylic acid transporters support mitochondrial metabolism in Plasmodium falciparum
Rajaram, K., Rangel, G. W., Munro, J. T., Nair, S. C., Elahi, R., Llinás, M. & Prigge, S. T., Jul 2025, In: Journal of Biological Chemistry. 301, 7, 110248.Research output: Contribution to journal › Article › peer-review
The plasmepsin-piperaquine paradox persists
Walsh, B., Summers, R. L., Rangel, G. W., Hagenah, L., Mok, S., Llinás, M., Fidock, D. A., Wirth, D. F. & Bopp, S., Jul 2025, In: PLoS pathogens. 21, 7, e1012779.Research output: Contribution to journal › Article › peer-review
Plasmodium blood stage development requires the chromatin remodeller Snf2L
Watzlowik, M. T., Silberhorn, E., Das, S., Singhal, R., Venugopal, K., Holzinger, S., Stokes, B., Schadt, E., Sollelis, L., Bonnell, V. A., Gow, M., Klingl, A., Marti, M., Llinás, M., Meissner, M. & Längst, G., Mar 27 2025, In: Nature. 639, 8056, p. 1069-1075 7 p.Research output: Contribution to journal › Article › peer-review
The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4-Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against Malaria
Woodland, J. G., Coertzen, D., Wicht, K. J., Hidalgo, V. F., Pasaje, C. F. A., Godoy, L. C., Qahash, T., Mmonwa, M. M., Dziwornu, G. A., Wambua, L., Harries, S., Korkor, C. M., Njoroge, M., Krugmann, L., Taylor, D., Leshabane, M., Langeveld, H., Rabie, T., Reader, J. & van der Watt, M. & 14 others, , Jul 7 2025, In: Angewandte Chemie - International Edition. 64, 28, e202425206.Research output: Contribution to journal › Article › peer-review
DNA sequence and chromatin differentiate sequence-specific transcription factor binding in the human malaria parasite Plasmodium falciparum
Bonnell, V. A., Zhang, Y., Brown, A. S., Horton, J., Josling, G. A., Chiu, T. P., Rohs, R., Mahony, S., Gordân, R. & Llinás, M., Sep 23 2024, In: Nucleic acids research. 52, 17, p. 10161-10179 19 p.Research output: Contribution to journal › Article › peer-review
Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology
Hagenah, L. M., Dhingra, S. K., Small-Saunders, J. L., Qahash, T., Willems, A., Schindler, K. A., Rangel, G. W., Gil-Iturbe, E., Kim, J., Akhundova, E., Yeo, T., Okombo, J., Mancia, F., Quick, M., Roepe, P. D., Llinás, M. & Fidock, D. A., Jan 2024, In: mBio. 15, 1Research output: Contribution to journal › Article › peer-review
Unraveling the complexities of ApiAP2 regulation in Plasmodium falciparum
Singhal, R., Prata, I. O., Bonnell, V. A. & Llinás, M., Nov 2024, In: Trends in Parasitology. 40, 11, p. 987-999 13 p.Research output: Contribution to journal › Review article › peer-review
Cripowellins Pause Plasmodium falciparum Intraerythrocytic Development at the Ring Stage
Butler, J. H., Painter, H. J., Bremers, E. K., Krai, P., Llinás, M. & Cassera, M. B., Mar 2023, In: Molecules. 28, 6, 2600.Research output: Contribution to journal › Article › peer-review
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target
Istvan, E. S., Guerra, F., Abraham, M., Huang, K. S., Rocamora, F., Zhao, H., Xu, L., Pasaje, C., Kumpornsin, K., Luth, M. R., Cui, H., Yang, T., Diaz, S. P., Gomez-Lorenzo, M. G., Qahash, T., Mittal, N., Ottilie, S., Niles, J., Lee, M. C. S. & Llinas, M. & 7 others, , Mar 8 2023, In: Science Translational Medicine. 15, 686, eadc9249.Research output: Contribution to journal › Article › peer-review
A Copper-Responsive Two-Component System Governs Lipoprotein Remodeling in Listeria monocytogenes
Komazin, G., Rizk, A. A., Armbruster, K. M., Bonnell, V. A., Llinás, M. & Meredith, T. C., Jan 2023, In: Journal of bacteriology. 205, 1Research output: Contribution to journal › Article › peer-review
The mitochondrion of Plasmodium falciparum is required for cellular acetyl-CoA metabolism and protein acetylation
Nair, S. C., Munro, J. T., Mann, A., Llinás, M. & Prigge, S. T., Apr 25 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 17, e2210929120.Research output: Contribution to journal › Article › peer-review
Author Correction: Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season (Nature Medicine, (2020), 26, 12, (1929-1940), 10.1038/s41591-020-1084-0)
Andrade, C. M., Fleckenstein, H., Thomson-Luque, R., Doumbo, S., Lima, N. F., Anderson, C., Hibbert, J., Hopp, C. S., Tran, T. M., Li, S., Niangaly, M., Cisse, H., Doumtabe, D., Skinner, J., Sturdevant, D., Ricklefs, S., Virtaneva, K., Asghar, M., Homann, M. V. & Turner, L. & 17 others, , Oct 2022, In: Nature Medicine. 28, 10, p. 2216 1 p.Research output: Contribution to journal › Comment/debate › peer-review