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Professor, Biochemistry & Molecular Biology
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Recent Publications
Chromatin state dynamics during the Plasmodium falciparum intraerythrocytic development cycle
Brown, A. S., Llinás, M. & Mahony, S., Dec 2026, In: BMC genomics. 27, 1, 142.Research output: Contribution to journal › Article › peer-review
Natural triterpenic phenolic esters target PfA-M17 in Plasmodium falciparum
Mamede, L., Rangel, G. W., Schmitt, M., Albrecht, S., Spichty, M., Bero, J., Beaufay, C., Florent, I., Llinás, M., Frédérich, M. & Quetin-Leclercq, J., Dec 2026, In: Malaria journal. 25, 1, 74.Research output: Contribution to journal › Article › peer-review
A Novel Class of Orally Bioavailable Phenylglycine–Benzoxaborole Conjugates with Antimalarial Activity and Potentially Novel Mechanism of Action
Morake, M., Taylor, D., Coertzen, D., Njoroge, M., Krugmann, L., Leshabane, M., da Rocha, S., Qahash, T., Girling, G., Coyle, R., Lee, M. C. S., Wittlin, S., Llinás, M., Birkholtz, L. M., Basarab, G. S. & Chibale, K., Jan 8 2026, In: ACS Medicinal Chemistry Letters. 17, 1, p. 22-31 10 p.Research output: Contribution to journal › Article › peer-review
Hexosamine biosynthesis disruption impairs GPI production and arrests Plasmodium falciparum growth at schizont stages
Alberione, M. P., Avalos-Padilla, Y., Rangel, G. W., Ramírez, M., Romero-Uruñuela, T., Fenollar, À., Ortega-Barrionuevo, J., Crispim, M., Smith, T. K., Llinás, M. & Izquierdo, L., Jul 2025, In: PLoS pathogens. 21, 7 July, e1012832.Research output: Contribution to journal › Article › peer-review
Degradation of ribosomal RNA during Plasmodium falciparum gametocytogenesis
Grünebast, J., Singhal, R., Bromley, R., Kanatani, S., Watson, K., Olson, S., Dumetz, F., Pascini, T. V., Tripathi, A., Dunning Hotopp, J. C., Sinnis, P., Llinás, M. & Serre, D., Nov 12 2025, In: mBio. 16, 11, p. 1-18 18 p.Research output: Contribution to journal › Article › peer-review
Structural characterization of the ACDC domain from ApiAP2 proteins, a potential molecular target against apicomplexan parasites
Le Berre, M., Tubiana, T., Waldner, P. R., Lazar, N., Li De La Sierra-Gallay, I., Santos, J. M., Llinás, M. & Nessler, S., Jan 1 2025, In: Acta Crystallographica Section D: Structural Biology. 81, p. 38-48 11 p.Research output: Contribution to journal › Article › peer-review
Metabolite profiling of Artemisia afra and Artemisia annua extracts reveals divergent effects on Plasmodium falciparum
Mamede, L., Rangel, G. W., Shinyuy, L. M., Boussif, N., Herent, M. F., Govaerts, B., Jansen, O., Ledoux, A., De Tullio, P., Quetin-Leclercq, J., Llinás, M. & Frédérich, M., Jan 2025, In: Phytomedicine. 136, 156361.Research output: Contribution to journal › Article › peer-review
Multiple, redundant carboxylic acid transporters support mitochondrial metabolism in Plasmodium falciparum
Rajaram, K., Rangel, G. W., Munro, J. T., Nair, S. C., Elahi, R., Llinás, M. & Prigge, S. T., Jul 2025, In: Journal of Biological Chemistry. 301, 7, 110248.Research output: Contribution to journal › Article › peer-review
The plasmepsin-piperaquine paradox persists
Walsh, B., Summers, R. L., Rangel, G. W., Hagenah, L., Mok, S., Llinás, M., Fidock, D. A., Wirth, D. F. & Bopp, S., Jul 2025, In: PLoS pathogens. 21, 7, e1012779.Research output: Contribution to journal › Article › peer-review
Plasmodium blood stage development requires the chromatin remodeller Snf2L
Watzlowik, M. T., Silberhorn, E., Das, S., Singhal, R., Venugopal, K., Holzinger, S., Stokes, B., Schadt, E., Sollelis, L., Bonnell, V. A., Gow, M., Klingl, A., Marti, M., Llinás, M., Meissner, M. & Längst, G., Mar 27 2025, In: Nature. 639, 8056, p. 1069-1075 7 p.Research output: Contribution to journal › Article › peer-review
The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4-Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against Malaria
Woodland, J. G., Coertzen, D., Wicht, K. J., Hidalgo, V. F., Pasaje, C. F. A., Godoy, L. C., Qahash, T., Mmonwa, M. M., Dziwornu, G. A., Wambua, L., Harries, S., Korkor, C. M., Njoroge, M., Krugmann, L., Taylor, D., Leshabane, M., Langeveld, H., Rabie, T., Reader, J. & van der Watt, M. & 14 others, , Jul 7 2025, In: Angewandte Chemie - International Edition. 64, 28, e202425206.Research output: Contribution to journal › Article › peer-review
DNA sequence and chromatin differentiate sequence-specific transcription factor binding in the human malaria parasite Plasmodium falciparum
Bonnell, V. A., Zhang, Y., Brown, A. S., Horton, J., Josling, G. A., Chiu, T. P., Rohs, R., Mahony, S., Gordân, R. & Llinás, M., Sep 23 2024, In: Nucleic acids research. 52, 17, p. 10161-10179 19 p.Research output: Contribution to journal › Article › peer-review
Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology
Hagenah, L. M., Dhingra, S. K., Small-Saunders, J. L., Qahash, T., Willems, A., Schindler, K. A., Rangel, G. W., Gil-Iturbe, E., Kim, J., Akhundova, E., Yeo, T., Okombo, J., Mancia, F., Quick, M., Roepe, P. D., Llinás, M. & Fidock, D. A., Jan 2024, In: mBio. 15, 1Research output: Contribution to journal › Article › peer-review
Unraveling the complexities of ApiAP2 regulation in Plasmodium falciparum
Singhal, R., Prata, I. O., Bonnell, V. A. & Llinás, M., Nov 2024, In: Trends in Parasitology. 40, 11, p. 987-999 13 p.Research output: Contribution to journal › Review article › peer-review
Cripowellins Pause Plasmodium falciparum Intraerythrocytic Development at the Ring Stage
Butler, J. H., Painter, H. J., Bremers, E. K., Krai, P., Llinás, M. & Cassera, M. B., Mar 2023, In: Molecules. 28, 6, 2600.Research output: Contribution to journal › Article › peer-review