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Professor, Biochemistry & Molecular Biology
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Recent Publications
Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology
Hagenah, L. M., Dhingra, S. K., Small-Saunders, J. L., Qahash, T., Willems, A., Schindler, K. A., Rangel, G. W., Gil-Iturbe, E., Kim, J., Akhundova, E., Yeo, T., Okombo, J., Mancia, F., Quick, M., Roepe, P. D., Llinás, M. & Fidock, D. A., Jan 2024, In: mBio. 15, 1Research output: Contribution to journal › Article › peer-review
Cripowellins Pause Plasmodium falciparum Intraerythrocytic Development at the Ring Stage
Butler, J. H., Painter, H. J., Bremers, E. K., Krai, P., Llinás, M. & Cassera, M. B., Mar 2023, In: Molecules. 28, 6, 2600.Research output: Contribution to journal › Article › peer-review
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target
Istvan, E. S., Guerra, F., Abraham, M., Huang, K. S., Rocamora, F., Zhao, H., Xu, L., Pasaje, C., Kumpornsin, K., Luth, M. R., Cui, H., Yang, T., Diaz, S. P., Gomez-Lorenzo, M. G., Qahash, T., Mittal, N., Ottilie, S., Niles, J., Lee, M. C. S. & Llinas, M. & 7 others, , Mar 8 2023, In: Science Translational Medicine. 15, 686, eadc9249.Research output: Contribution to journal › Article › peer-review
A Copper-Responsive Two-Component System Governs Lipoprotein Remodeling in Listeria monocytogenes
Komazin, G., Rizk, A. A., Armbruster, K. M., Bonnell, V. A., Llinás, M. & Meredith, T. C., Jan 2023, In: Journal of bacteriology. 205, 1Research output: Contribution to journal › Article › peer-review
The mitochondrion of Plasmodium falciparum is required for cellular acetyl-CoA metabolism and protein acetylation
Nair, S. C., Munro, J. T., Mann, A., Llinás, M. & Prigge, S. T., Apr 25 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 17, e2210929120.Research output: Contribution to journal › Article › peer-review
Author Correction: Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season (Nature Medicine, (2020), 26, 12, (1929-1940), 10.1038/s41591-020-1084-0)
Andrade, C. M., Fleckenstein, H., Thomson-Luque, R., Doumbo, S., Lima, N. F., Anderson, C., Hibbert, J., Hopp, C. S., Tran, T. M., Li, S., Niangaly, M., Cisse, H., Doumtabe, D., Skinner, J., Sturdevant, D., Ricklefs, S., Virtaneva, K., Asghar, M., Homann, M. V. & Turner, L. & 17 others, , Oct 2022, In: Nature Medicine. 28, 10, p. 2216 1 p.Research output: Contribution to journal › Comment/debate › peer-review
The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages
Arendse, L. B., Murithi, J. M., Qahash, T., Pasaje, C. F. A., Godoy, L. C., Dey, S., Gibhard, L., Ghidelli-Disse, S., Drewes, G., Bantscheff, M., Lafuente-Monasterio, M. J., Fienberg, S., Wambua, L., Gachuhi, S., Coertzen, D., van der Watt, M., Reader, J., Aswat, A. S., Erlank, E. & Venter, N. & 10 others, , Oct 19 2022, In: Science Translational Medicine. 14, 667, eabo7219.Research output: Contribution to journal › Article › peer-review
Publisher Correction: The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites (Nature Microbiology, (2022), 7, 2, (289-299), 10.1038/s41564-021-01045-0)
Campelo Morillo, R. A., Tong, X., Xie, W., Abel, S., Orchard, L. M., Daher, W., Patel, D. J., Llinás, M., Le Roch, K. G. & Kafsack, B. F. C., Mar 2022, In: Nature Microbiology. 7, 3, p. 464 1 p.Research output: Contribution to journal › Comment/debate › peer-review
The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites
Campelo Morillo, R. A., Tong, X., Xie, W., Abel, S., Orchard, L. M., Daher, W., Patel, D. J., Llinás, M., Le Roch, K. G. & Kafsack, B. F. C., Feb 2022, In: Nature Microbiology. 7, 2, p. 289-299 11 p.Research output: Contribution to journal › Article › peer-review
Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183
de Vries, L. E., Jansen, P. A. M., Barcelo, C., Munro, J., Verhoef, J. M. J., Pasaje, C. F. A., Rubiano, K., Striepen, J., Abla, N., Berning, L., Bolscher, J. M., Demarta-Gatsi, C., Henderson, R. W. M., Huijs, T., Koolen, K. M. J., Tumwebaze, P. K., Yeo, T., Aguiar, A. C. C., Angulo-Barturen, I. & Churchyard, A. & 25 others, , Dec 2022, In: Nature communications. 13, 1, 2158.Research output: Contribution to journal › Article › peer-review
Anti-inflammation and antimalarial profile of 5-pyridin-2-yl-1H-[1,2,4]triazole-3-carboxylic acid ethyl ester as a low molecular intermediate for hybrid drug synthesis
Eya’ane Meva, F., Prior, T. J., Evans, D. J., Shah, S., Tamngwa, C. F., Belengue, H. G. L., Mang, R. E., Munro, J., Qahash, T. & Llinás, M., Feb 2022, In: Research on Chemical Intermediates. 48, 2, p. 885-898 14 p.Research output: Contribution to journal › Article › peer-review
Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages
Okombo, J., Mok, S., Qahash, T., Yeo, T., Bath, J., Orchard, L. M., Owens, E., Koo, I., Albert, I., Llinás, M. & Fidock, D. A., Oct 2022, In: PLoS pathogens. 18, 10, e1010926.Research output: Contribution to journal › Article › peer-review
Author Correction: Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development (Nature Communications, (2018), 9, 1, (2656), 10.1038/s41467-018-04966-3)
Painter, H. J., Chung, N. C., Sebastian, A., Albert, I., Storey, J. D. & Llinás, M., Dec 2022, In: Nature communications. 13, 1, 1497.Research output: Contribution to journal › Comment/debate › peer-review
Inhibitors of ApiAP2 protein DNA binding exhibit multistage activity against Plasmodium parasites
Russell, T. J., De Silva, E. K., Crowley, V. M., Shaw-Saliba, K., Dube, N., Josling, G., Pasaje, C. F. A., Kouskoumvekaki, I., Panagiotou, G., Niles, J. C., Jacobs-Lorena, M., Okafor, C. D., Gamo, F. J. & Llinás, M., Oct 2022, In: PLoS pathogens. 18, 10, e1010887.Research output: Contribution to journal › Article › peer-review
Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention
Summers, R. L., Pasaje, C. F. A., Pisco, J. P., Striepen, J., Luth, M. R., Kumpornsin, K., Carpenter, E. F., Munro, J. T., Lin, D., Plater, A., Punekar, A. S., Shepherd, A. M., Shepherd, S. M., Vanaerschot, M., Murithi, J. M., Rubiano, K., Akidil, A., Ottilie, S., Mittal, N. & Dilmore, A. H. & 14 others, , Feb 17 2022, In: Cell Chemical Biology. 29, 2, p. 191-201.e8Research output: Contribution to journal › Article › peer-review