Manuel Llinás
Affiliate Researcher
Titles and Affiliations
Professor, Biochemistry & Molecular Biology
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Recent Publications
Chromatin state dynamics during the Plasmodium falciparum intraerythrocytic development cycle
Brown, A. S., Llinás, M. & Mahony, S., Dec 2026, In: BMC genomics. 27, 1, 142.Research output: Contribution to journal › Article › peer-review
Effect of Stereochemistry on the Antiplasmodial Activity and Metabolomic Profile of Novel Tadalafil Analogues
Elhalawaty, E. A., Alseedy, H. A., Woodland, J. G., Wicht, K. J., Swart, T., Rangel, G. W., Hoppe, H. C., Chibale, K., Llinás, M., Abadi, A. H. & Ahmed, N. S., May 14 2026, In: ACS Medicinal Chemistry Letters. 17, 5, p. 1067-1077 11 p.Research output: Contribution to journal › Letter › peer-review
Metabolomics reveals potentiated metabolic perturbations induced by antimalarial drug combinations against Plasmodium falciparum in vitro
Eya'ane Meva, F., Qahash, T., Arinaga, J. & Llinás, M., Sep 2026, In: Experimental Parasitology. 288, 109171.Research output: Contribution to journal › Article › peer-review
Identification of genetic markers of quinine partial resistance in Plasmodium falciparum
Kanai, M., Mok, S., Yeo, T., Shears, M. J., Jeon, J. H., Narwal, S. K., Ross, L. S., Wiradiputri, K., Haile, M. T., Tripathi, A. K., Mlambo, G., Kim, J., Gil-Iturbe, E., Park, H., Ndiaye, T., Okombo, J., Ward, K. E., Rozenberg, F. D., Fairhurst, K. J. & Gavula, S. M. & 11 others, , Aug 2026, In: Nature Microbiology. 11, 8, p. 2213-2231 19 p.Research output: Contribution to journal › Article › peer-review
Natural triterpenic phenolic esters target PfA-M17 in Plasmodium falciparum
Mamede, L., Rangel, G. W., Schmitt, M., Albrecht, S., Spichty, M., Bero, J., Beaufay, C., Florent, I., Llinás, M., Frédérich, M. & Quetin-Leclercq, J., Dec 2026, In: Malaria journal. 25, 1, 74.Research output: Contribution to journal › Article › peer-review
A Novel Class of Orally Bioavailable Phenylglycine–Benzoxaborole Conjugates with Antimalarial Activity and Potentially Novel Mechanism of Action
Morake, M., Taylor, D., Coertzen, D., Njoroge, M., Krugmann, L., Leshabane, M., da Rocha, S., Qahash, T., Girling, G., Coyle, R., Lee, M. C. S., Wittlin, S., Llinás, M., Birkholtz, L. M., Basarab, G. S. & Chibale, K., Jan 8 2026, In: ACS Medicinal Chemistry Letters. 17, 1, p. 22-31 10 p.Research output: Contribution to journal › Article › peer-review
Collateral hypersensitivity between ZY19489 and piperaquine neutralizes PfCRT-mediated drug efflux and Plasmodium falciparum resistance
Okombo, J., Ndiaye, T., Qahash, T., Moura, I. M. R., Gil-Iturbe, E., Hagenah, L. M., Bridgford, J. L., Bonatto, V., Ward, K. E., Yeo, T., Narwal, S. K., Orta, L. V., Anderson, I., Dhingra, S. K., Pasaje, C. F. A., Park, H., Kim, J., Guido, R. V. C., Jiménez-Diaz, M. B. & Angulo-Barturen, I. & 10 others, , Dec 2026, In: Nature communications. 17, 1, 5441.Research output: Contribution to journal › Article › peer-review
ATAD3 megadalton complex in Plasmodium falciparum is essential for mitochondrial and cellular viability
Okoye, I. C., Lamb, I. M., Cheung, Y. W., Morrisey, J. M., Sharma, M., Kumar, R., Dass, S., Shukla, A., Rell, R. S., Mather, M. W., Llinás, M., Chang, Y. W. & Vaidya, A. B., Jun 2026, In: PLoS pathogens. 22, 6 June, e1014317.Research output: Contribution to journal › Article › peer-review
A single valine to leucine switch disrupts Plasmodium falciparum AP2-G DNA binding and reveals GDV1’s role in ap2-g activation
Prajapati, S. K., Dong, J. X., Morahan, B. J., Dotrang, T., Barbeau, M. C., Williams, A. E., Hupalo, D., Wilkerson, M. D., Dalgard, C. L., Kafsack, B. F. C., Llinás, M. & Williamson, K. C., Dec 2026, In: Nature communications. 17, 1, 1719.Research output: Contribution to journal › Article › peer-review
Hexosamine biosynthesis disruption impairs GPI production and arrests Plasmodium falciparum growth at schizont stages
Alberione, M. P., Avalos-Padilla, Y., Rangel, G. W., Ramírez, M., Romero-Uruñuela, T., Fenollar, À., Ortega-Barrionuevo, J., Crispim, M., Smith, T. K., Llinás, M. & Izquierdo, L., Jul 2025, In: PLoS pathogens. 21, 7 July, e1012832.Research output: Contribution to journal › Article › peer-review
Degradation of ribosomal RNA during Plasmodium falciparum gametocytogenesis
Grünebast, J., Singhal, R., Bromley, R., Kanatani, S., Watson, K., Olson, S., Dumetz, F., Pascini, T. V., Tripathi, A., Dunning Hotopp, J. C., Sinnis, P., Llinás, M. & Serre, D., Nov 12 2025, In: mBio. 16, 11, p. 1-18 18 p.Research output: Contribution to journal › Article › peer-review
Structural characterization of the ACDC domain from ApiAP2 proteins, a potential molecular target against apicomplexan parasites
Le Berre, M., Tubiana, T., Waldner, P. R., Lazar, N., Li De La Sierra-Gallay, I., Santos, J. M., Llinás, M. & Nessler, S., Jan 1 2025, In: Acta Crystallographica Section D: Biological Crystallography. 81, p. 38-48 11 p.Research output: Contribution to journal › Article › peer-review
Metabolite profiling of Artemisia afra and Artemisia annua extracts reveals divergent effects on Plasmodium falciparum
Mamede, L., Rangel, G. W., Shinyuy, L. M., Boussif, N., Herent, M. F., Govaerts, B., Jansen, O., Ledoux, A., De Tullio, P., Quetin-Leclercq, J., Llinás, M. & Frédérich, M., Jan 2025, In: Phytomedicine. 136, 156361.Research output: Contribution to journal › Article › peer-review
Multiple, redundant carboxylic acid transporters support mitochondrial metabolism in Plasmodium falciparum
Rajaram, K., Rangel, G. W., Munro, J. T., Nair, S. C., Elahi, R., Llinás, M. & Prigge, S. T., Jul 2025, In: Journal of Biological Chemistry. 301, 7, 110248.Research output: Contribution to journal › Article › peer-review
The plasmepsin-piperaquine paradox persists
Walsh, B., Summers, R. L., Rangel, G. W., Hagenah, L., Mok, S., Llinás, M., Fidock, D. A., Wirth, D. F. & Bopp, S., Jul 2025, In: PLoS pathogens. 21, 7, e1012779.Research output: Contribution to journal › Article › peer-review
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