Manuel Llinás

Affiliate Researcher
Titles and Affiliations
Professor, Biochemistry & Molecular Biology

In the News

Research Keywords

Recent Publications

Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology

Hagenah, L. M., Dhingra, S. K., Small-Saunders, J. L., Qahash, T., Willems, A., Schindler, K. A., Rangel, G. W., Gil-Iturbe, E., Kim, J., Akhundova, E., Yeo, T., Okombo, J., Mancia, F., Quick, M., Roepe, P. D., Llinás, M. & Fidock, D. A., Jan 16 2024, In: mBio. 15, 1, p. e0183223

Research output: Contribution to journalArticlepeer-review

Cripowellins Pause Plasmodium falciparum Intraerythrocytic Development at the Ring Stage

Butler, J. H., Painter, H. J., Bremers, E. K., Krai, P., Llinás, M. & Cassera, M. B., Mar 2023, In: Molecules. 28, 6, 2600.

Research output: Contribution to journalArticlepeer-review

Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target

Istvan, E. S., Guerra, F., Abraham, M., Huang, K. S., Rocamora, F., Zhao, H., Xu, L., Pasaje, C., Kumpornsin, K., Luth, M. R., Cui, H., Yang, T., Diaz, S. P., Gomez-Lorenzo, M. G., Qahash, T., Mittal, N., Ottilie, S., Niles, J., Lee, M. C. S., Llinas, M., & 7 othersKato, N., Okombo, J., Fidock, D. A., Schimmel, P., Gamo, F. J., Goldberg, D. E. & Winzeler, E. A., Mar 8 2023, In: Science Translational Medicine. 15, 686, eadc9249.

Research output: Contribution to journalArticlepeer-review

A Copper-Responsive Two-Component System Governs Lipoprotein Remodeling in Listeria monocytogenes

Komazin, G., Rizk, A. A., Armbruster, K. M., Bonnell, V. A., Llinás, M. & Meredith, T. C., Jan 2023, In: Journal of bacteriology. 205, 1

Research output: Contribution to journalArticlepeer-review

The mitochondrion of Plasmodium falciparum is required for cellular acetyl-CoA metabolism and protein acetylation

Nair, S. C., Munro, J. T., Mann, A., Llinás, M. & Prigge, S. T., Apr 25 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 17, e2210929120.

Research output: Contribution to journalArticlepeer-review

Author Correction: Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season (Nature Medicine, (2020), 26, 12, (1929-1940), 10.1038/s41591-020-1084-0)

Andrade, C. M., Fleckenstein, H., Thomson-Luque, R., Doumbo, S., Lima, N. F., Anderson, C., Hibbert, J., Hopp, C. S., Tran, T. M., Li, S., Niangaly, M., Cisse, H., Doumtabe, D., Skinner, J., Sturdevant, D., Ricklefs, S., Virtaneva, K., Asghar, M., Homann, M. V., Turner, L., & 17 othersMartins, J., Allman, E. L., N’Dri, M. E., Winkler, V., Llinás, M., Lavazec, C., Martens, C., Färnert, A., Kayentao, K., Ongoiba, A., Lavstsen, T., Osório, N. S., Otto, T. D., Recker, M., Traore, B., Crompton, P. D. & Portugal, S., Oct 2022, In: Nature Medicine. 28, 10, p. 2216 1 p.

Research output: Contribution to journalComment/debatepeer-review

The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages

Arendse, L. B., Murithi, J. M., Qahash, T., Pasaje, C. F. A., Godoy, L. C., Dey, S., Gibhard, L., Ghidelli-Disse, S., Drewes, G., Bantscheff, M., Lafuente-Monasterio, M. J., Fienberg, S., Wambua, L., Gachuhi, S., Coertzen, D., van der Watt, M., Reader, J., Aswat, A. S., Erlank, E., Venter, N., & 10 othersMittal, N., Luth, M. R., Ottilie, S., Winzeler, E. A., Koekemoer, L. L., Birkholtz, L. M., Niles, J. C., Llinás, M., Fidock, D. A. & Chibale, K., Oct 19 2022, In: Science Translational Medicine. 14, 667, eabo7219.

Research output: Contribution to journalArticlepeer-review

Publisher Correction: The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites (Nature Microbiology, (2022), 7, 2, (289-299), 10.1038/s41564-021-01045-0)

Campelo Morillo, R. A., Tong, X., Xie, W., Abel, S., Orchard, L. M., Daher, W., Patel, D. J., Llinás, M., Le Roch, K. G. & Kafsack, B. F. C., Mar 2022, In: Nature Microbiology. 7, 3, p. 464 1 p.

Research output: Contribution to journalComment/debatepeer-review

The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites

Campelo Morillo, R. A., Tong, X., Xie, W., Abel, S., Orchard, L. M., Daher, W., Patel, D. J., Llinás, M., Le Roch, K. G. & Kafsack, B. F. C., Feb 2022, In: Nature Microbiology. 7, 2, p. 289-299 11 p.

Research output: Contribution to journalArticlepeer-review

Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183

de Vries, L. E., Jansen, P. A. M., Barcelo, C., Munro, J., Verhoef, J. M. J., Pasaje, C. F. A., Rubiano, K., Striepen, J., Abla, N., Berning, L., Bolscher, J. M., Demarta-Gatsi, C., Henderson, R. W. M., Huijs, T., Koolen, K. M. J., Tumwebaze, P. K., Yeo, T., Aguiar, A. C. C., Angulo-Barturen, I., Churchyard, A., & 25 othersBaum, J., Fernández, B. C., Fuchs, A., Gamo, F. J., Guido, R. V. C., Jiménez-Diaz, M. B., Pereira, D. B., Rochford, R., Roesch, C., Sanz, L. M., Trevitt, G., Witkowski, B., Wittlin, S., Cooper, R. A., Rosenthal, P. J., Sauerwein, R. W., Schalkwijk, J., Hermkens, P. H. H., Bonnert, R. V., Campo, B., Fidock, D. A., Llinás, M., Niles, J. C., Kooij, T. W. A. & Dechering, K. J., Dec 2022, In: Nature communications. 13, 1, 2158.

Research output: Contribution to journalArticlepeer-review

Anti-inflammation and antimalarial profile of 5-pyridin-2-yl-1H-[1,2,4]triazole-3-carboxylic acid ethyl ester as a low molecular intermediate for hybrid drug synthesis

Eya’ane Meva, F., Prior, T. J., Evans, D. J., Shah, S., Tamngwa, C. F., Belengue, H. G. L., Mang, R. E., Munro, J., Qahash, T. & Llinás, M., Feb 2022, In: Research on Chemical Intermediates. 48, 2, p. 885-898 14 p.

Research output: Contribution to journalArticlepeer-review

Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages

Okombo, J., Mok, S., Qahash, T., Yeo, T., Bath, J., Orchard, L. M., Owens, E., Koo, I., Albert, I., Llinás, M. & Fidock, D. A., Oct 2022, In: PLoS pathogens. 18, 10, e1010926.

Research output: Contribution to journalArticlepeer-review

Author Correction: Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development (Nature Communications, (2018), 9, 1, (2656), 10.1038/s41467-018-04966-3)

Painter, H. J., Chung, N. C., Sebastian, A., Albert, I., Storey, J. D. & Llinás, M., Dec 2022, In: Nature communications. 13, 1, 1497.

Research output: Contribution to journalComment/debatepeer-review

Inhibitors of ApiAP2 protein DNA binding exhibit multistage activity against Plasmodium parasites

Russell, T. J., De Silva, E. K., Crowley, V. M., Shaw-Saliba, K., Dube, N., Josling, G., Pasaje, C. F. A., Kouskoumvekaki, I., Panagiotou, G., Niles, J. C., Jacobs-Lorena, M., Okafor, C. D., Gamo, F. J. & Llinás, M., Oct 2022, In: PLoS pathogens. 18, 10, e1010887.

Research output: Contribution to journalArticlepeer-review

Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention

Summers, R. L., Pasaje, C. F. A., Pisco, J. P., Striepen, J., Luth, M. R., Kumpornsin, K., Carpenter, E. F., Munro, J. T., Lin, D., Plater, A., Punekar, A. S., Shepherd, A. M., Shepherd, S. M., Vanaerschot, M., Murithi, J. M., Rubiano, K., Akidil, A., Ottilie, S., Mittal, N., Dilmore, A. H., & 14 othersWon, M., Mandt, R. E. K., McGowen, K., Owen, E., Walpole, C., Llinás, M., Lee, M. C. S., Winzeler, E. A., Fidock, D. A., Gilbert, I. H., Wirth, D. F., Niles, J. C., Baragaña, B. & Lukens, A. K., Feb 17 2022, In: Cell Chemical Biology. 29, 2, p. 191-201.e8

Research output: Contribution to journalArticlepeer-review