Manuel Llinás

Affiliate Researcher
Titles and Affiliations
Professor, Biochemistry & Molecular Biology

In the News

Research Keywords

Recent Publications

Author Correction: Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season (Nature Medicine, (2020), 26, 12, (1929-1940), 10.1038/s41591-020-1084-0)

Andrade, C. M., Fleckenstein, H., Thomson-Luque, R., Doumbo, S., Lima, N. F., Anderson, C., Hibbert, J., Hopp, C. S., Tran, T. M., Li, S., Niangaly, M., Cisse, H., Doumtabe, D., Skinner, J., Sturdevant, D., Ricklefs, S., Virtaneva, K., Asghar, M., Homann, M. V., Turner, L., & 17 othersMartins, J., Allman, E. L., N’Dri, M. E., Winkler, V., Llinás, M., Lavazec, C., Martens, C., Färnert, A., Kayentao, K., Ongoiba, A., Lavstsen, T., Osório, N. S., Otto, T. D., Recker, M., Traore, B., Crompton, P. D. & Portugal, S., Oct 2022, In: Nature Medicine. 28, 10, p. 2216 1 p.

Research output: Contribution to journalComment/debatepeer-review

Publisher Correction: The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites (Nature Microbiology, (2022), 7, 2, (289-299), 10.1038/s41564-021-01045-0)

Campelo Morillo, R. A., Tong, X., Xie, W., Abel, S., Orchard, L. M., Daher, W., Patel, D. J., Llinás, M., Le Roch, K. G. & Kafsack, B. F. C., Mar 2022, In: Nature Microbiology. 7, 3, p. 464 1 p.

Research output: Contribution to journalComment/debatepeer-review

The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites

Campelo Morillo, R. A., Tong, X., Xie, W., Abel, S., Orchard, L. M., Daher, W., Patel, D. J., Llinás, M., Le Roch, K. G. & Kafsack, B. F. C., Feb 2022, In: Nature Microbiology. 7, 2, p. 289-299 11 p.

Research output: Contribution to journalArticlepeer-review

Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183

de Vries, L. E., Jansen, P. A. M., Barcelo, C., Munro, J., Verhoef, J. M. J., Pasaje, C. F. A., Rubiano, K., Striepen, J., Abla, N., Berning, L., Bolscher, J. M., Demarta-Gatsi, C., Henderson, R. W. M., Huijs, T., Koolen, K. M. J., Tumwebaze, P. K., Yeo, T., Aguiar, A. C. C., Angulo-Barturen, I., Churchyard, A., & 25 othersBaum, J., Fernández, B. C., Fuchs, A., Gamo, F. J., Guido, R. V. C., Jiménez-Diaz, M. B., Pereira, D. B., Rochford, R., Roesch, C., Sanz, L. M., Trevitt, G., Witkowski, B., Wittlin, S., Cooper, R. A., Rosenthal, P. J., Sauerwein, R. W., Schalkwijk, J., Hermkens, P. H. H., Bonnert, R. V., Campo, B., Fidock, D. A., Llinás, M., Niles, J. C., Kooij, T. W. A. & Dechering, K. J., Dec 2022, In: Nature communications. 13, 1, 2158.

Research output: Contribution to journalArticlepeer-review

Anti-inflammation and antimalarial profile of 5-pyridin-2-yl-1H-[1,2,4]triazole-3-carboxylic acid ethyl ester as a low molecular intermediate for hybrid drug synthesis

Eya’ane Meva, F., Prior, T. J., Evans, D. J., Shah, S., Tamngwa, C. F., Belengue, H. G. L., Mang, R. E., Munro, J., Qahash, T. & Llinás, M., Feb 2022, In: Research on Chemical Intermediates. 48, 2, p. 885-898 14 p.

Research output: Contribution to journalArticlepeer-review

Author Correction: Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development (Nature Communications, (2018), 9, 1, (2656), 10.1038/s41467-018-04966-3)

Painter, H. J., Chung, N. C., Sebastian, A., Albert, I., Storey, J. D. & Llinás, M., Dec 2022, In: Nature communications. 13, 1, 1497.

Research output: Contribution to journalComment/debatepeer-review

Inhibitors of ApiAP2 protein DNA binding exhibit multistage activity against Plasmodium parasites

Russell, T. J., De Silva, E. K., Crowley, V. M., Shaw-Saliba, K., Dube, N., Josling, G., Pasaje, C. F. A., Kouskoumvekaki, I., Panagiotou, G., Niles, J. C., Jacobs-Lorena, M., Denise Okafor, C., Gamo, F. J. & Llinás, M., Oct 1 2022, In: PLoS pathogens. 18, 10, p. e1010887

Research output: Contribution to journalArticlepeer-review

Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention

Summers, R. L., Pasaje, C. F. A., Pisco, J. P., Striepen, J., Luth, M. R., Kumpornsin, K., Carpenter, E. F., Munro, J. T., Lin, D., Plater, A., Punekar, A. S., Shepherd, A. M., Shepherd, S. M., Vanaerschot, M., Murithi, J. M., Rubiano, K., Akidil, A., Ottilie, S., Mittal, N., Dilmore, A. H., & 14 othersWon, M., Mandt, R. E. K., McGowen, K., Owen, E., Walpole, C., Llinás, M., Lee, M. C. S., Winzeler, E. A., Fidock, D. A., Gilbert, I. H., Wirth, D. F., Niles, J. C., Baragaña, B. & Lukens, A. K., Feb 17 2022, In: Cell Chemical Biology. 29, 2, p. 191-201.e8

Research output: Contribution to journalArticlepeer-review

H3K36 methylation reprograms gene expression to drive early gametocyte development in Plasmodium falciparum

Connacher, J., Josling, G. A., Orchard, L. M., Reader, J., Llinás, M. & Birkholtz, L. M., Dec 2021, In: Epigenetics and Chromatin. 14, 1, 19.

Research output: Contribution to journalArticlepeer-review

The Kringle of Life

Llinás, M., Aug 2021, In: Protein Journal. 40, 4, p. 454-456 3 p.

Research output: Contribution to journalArticlepeer-review

Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival

Mok, S., Stokes, B. H., Gnädig, N. F., Ross, L. S., Yeo, T., Amaratunga, C., Allman, E., Solyakov, L., Bottrill, A. R., Tripathi, J., Fairhurst, R. M., Llinás, M., Bozdech, Z., Tobin, A. B. & Fidock, D. A., Dec 1 2021, In: Nature communications. 12, 1, 530.

Research output: Contribution to journalArticlepeer-review

Chemogenomic Fingerprints Associated with Stage-Specific Gametocytocidal Compound Action against Human Malaria Parasites

Niemand, J., Van Biljon, R., Van Der Watt, M., Van Heerden, A., Reader, J., Van Wyk, R., Orchard, L., Chibale, K., Llinás, M. & Birkholtz, L. M., Oct 8 2021, In: ACS Infectious Diseases. 7, 10, p. 2904-2916 13 p.

Research output: Contribution to journalArticlepeer-review

Atypical molecular basis for drug resistance to mitochondrial function inhibitors in plasmodium falciparum

Painter, H. J., Morrisey, J. M., Mather, M. W., Orchard, L. M., Luck, C., Smilkstein, M. J., Riscoe, M. K., Vaidya, A. B. & Llinás, M., Mar 2021, In: Antimicrobial agents and chemotherapy. 65, 3, e02143-20.

Research output: Contribution to journalArticlepeer-review

Re-Envisioning Anti-Apicomplexan Parasite Drug Discovery Approaches

Rangel, G. W. & Llinás, M., Jun 11 2021, In: Frontiers in Cellular and Infection Microbiology. 11, 691121.

Research output: Contribution to journalReview articlepeer-review

Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box

Reader, J., van der Watt, M. E., Taylor, D., Le Manach, C., Mittal, N., Ottilie, S., Theron, A., Moyo, P., Erlank, E., Nardini, L., Venter, N., Lauterbach, S., Bezuidenhout, B., Horatscheck, A., van Heerden, A., Spillman, N. J., Cowell, A. N., Connacher, J., Opperman, D., Orchard, L. M., & 13 othersLlinás, M., Istvan, E. S., Goldberg, D. E., Boyle, G. A., Calvo, D., Mancama, D., Coetzer, T. L., Winzeler, E. A., Duffy, J., Koekemoer, L. L., Basarab, G., Chibale, K. & Birkholtz, L. M., Dec 1 2021, In: Nature communications. 12, 1, 269.

Research output: Contribution to journalArticlepeer-review