Research Summary
Research is focused on the three likely candidates for NRs that respond to dietary fatty acids: PPAR, RXR and LXR. In particular, the peroxisome proliferator-activated receptors (PPARs; PPARa, ß/d and ?) are of particular interest as they serve key roles in toxicology, carcinogenesis and nutrition. Study the ligands of these receptors, the genes they affect and the physiological consequences of their activation.
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Research Keywords
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Projects
Recent Publications
Bile salt hydrolase catalyses formation of amine-conjugated bile acids
Rimal, B., Collins, S. L., Tanes, C. E., Rocha, E. R., Granda, M. A., Solanki, S., Hoque, N. J., Gentry, E. C., Koo, I., Reilly, E. R., Hao, F., Paudel, D., Singh, V., Yan, T., Kim, M. S., Bittinger, K., Zackular, J. P., Krausz, K. W., Desai, D. & Amin, S. & 10 others, , Feb 22 2024, In: Nature. 626, 8000, p. 859-863 5 p.Research output: Contribution to journal › Article › peer-review
Toxicity and chemical composition of commercial road palliatives versus oil and gas produced waters
Farnan, J., Vanden Heuvel, J. P., Dorman, F. L., Warner, N. R. & Burgos, W. D., Oct 1 2023, In: Environmental Pollution. 334, 122184.Research output: Contribution to journal › Article › peer-review
Preclinical Demonstration of a Novel Treatment with High Efficacy and No Detectable Toxicity for Inflammatory Skin Conditions including Psoriasis
Vanden Heuvel, J. P., Zhou, S., Patel, A. B., Kamerow, H. N., Baran, P. & Ford, J. P., 2023, In: BioMed Research International. 2023, 4878774.Research output: Contribution to journal › Article › peer-review
Lipoxygenase catalyzed metabolites derived from docosahexaenoic acid are promising antitumor agents against breast cancer
Chen, K. M., Thompson, H., Vanden-Heuvel, J. P., Sun, Y. W., Trushin, N., Aliaga, C., Gowda, K., Amin, S., Stanley, B., Manni, A. & El-Bayoumy, K., Dec 2021, In: Scientific reports. 11, 1, 410.Research output: Contribution to journal › Article › peer-review
Accumulating evidence to support the safe and efficacious use of a proprietary blend of capsaicinoids in mediating risk factors for obesity
Mariwala, J. K., Rai, D., Padigaru, M., Ashok Morde, A., Maddox, E., Maalouf, S., Smith, K. & Vanden Heuvel, J. P., Jun 2021, In: Food Science and Nutrition. 9, 6, p. 2823-2835 13 p.Research output: Contribution to journal › Article › peer-review
Detection and removal of biologically active organic micropollutants from hospital wastewater
Castillo Meza, L., Piotrowski, P., Farnan, J., Tasker, T. L., Xiong, B., Weggler, B., Murrell, K., Dorman, F. L., Vanden Heuvel, J. P. & Burgos, W. D., Jan 15 2020, In: Science of the Total Environment. 700, 134469.Research output: Contribution to journal › Article › peer-review
Diets low in saturated fat with different unsaturated fatty acid profiles similarly increase serum-mediated cholesterol efflux from THP-1 macrophages in a population with or at risk for metabolic syndrome: The Canola Oil Multicenter Intervention Trial
Liu, X., Garban, J., Jones, P. J., Heuvel, J. V., Lamarche, B., Jenkins, D. J., Connelly, P. W., Couture, P., Pu, S., Fleming, J. A., West, S. G. & Kris-Etherton, P. M., May 1 2018, In: Journal of Nutrition. 148, 5, p. 721-728 8 p.Research output: Contribution to journal › Article › peer-review
Environmental and Human Health Impacts of Spreading Oil and Gas Wastewater on Roads
Tasker, T. L., Burgos, W. D., Piotrowski, P., Castillo-Meza, L., Blewett, T. A., Ganow, K. B., Stallworth, A., Delompré, P. L. M., Goss, G. G., Fowler, L. B., Vanden Heuvel, J. P., Dorman, F. & Warner, N. R., Jun 19 2018, In: Environmental Science and Technology. 52, 12, p. 7081-7091 11 p.Research output: Contribution to journal › Article › peer-review
Replication study: Systematic identification of genomic markers of drug sensitivity in cancer cells
Reproducibility Project: Cancer Biology, Jan 9 2018, In: eLife. 7, e29747.Research output: Contribution to journal › Article › peer-review
Effects of cranberry extracts on gene expression in THP-1 cells
Hannon, D. B., Thompson, J. T., Khoo, C., Juturu, V. & Vanden Heuvel, J. P., Jan 1 2017, In: Food Science and Nutrition. 5, 1, p. 148-159 12 p.Research output: Contribution to journal › Article › peer-review
Biliverdin reductase A attenuates hepatic steatosis by inhibition of Glycogen Synthase Kinase (GSK) 3β phosphorylation of serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α
Hinds, T. D., Burns, K. A., Hosick, P. A., McBeth, L., Nestor-Kalinoski, A., Drummond, H. A., Alamodi, A. A., Hankins, M. W., Vanden Heuvel, J. P. & Stec, D. E., Nov 25 2016, In: Journal of Biological Chemistry. 291, 48, p. 25179-25191 13 p.Research output: Contribution to journal › Article › peer-review
Therapeutic potential of GW501516 and the role of Peroxisome proliferator-activated receptor β/δ and B-cell lymphoma 6 in inflammatory signaling in human pancreatic cancer cells
Smith, R. W., Coleman, J. D., Thompson, J. T. & Vanden Heuvel, J. P., Dec 1 2016, In: Biochemistry and Biophysics Reports. 8, p. 395-402 8 p.Research output: Contribution to journal › Article › peer-review
Registered report: Systematic identification of genomic markers of drug sensitivity in cancer cells
Reproducibility Project: Cancer Biology, Jun 23 2016, In: eLife. 5, JUNE2016, e13620.Research output: Contribution to journal › Article › peer-review
Differential nucleobase protection against 5-fluorouracil toxicity for squamous and columnar cells: Implication for tissue function and oncogenesis
Vanden Heuvel, J. P., Thompson, J. T., Albrecht, P., Mandetta, D., Kamerow, H. & Ford, J. P., Oct 22 2015, In: Investigational New Drugs. 33, 5, p. 1003-1011 9 p.Research output: Contribution to journal › Article › peer-review
Effects of whole and refined grains in a weight-loss diet on markers of metabolic syndrome in individuals with increased waist circumference: A randomized controlled-feeding trial
Jackson, K. H., West, S. G., Vanden Heuvel, J. P., Jonnalagadda, S. S., Ross, A. B., Hill, A. M., Grieger, J. A., Lemieux, S. K. & Kris-Etherton, P. M., 2014, In: American Journal of Clinical Nutrition. 100, 2, p. 577-586 10 p.Research output: Contribution to journal › Article › peer-review