Christian Huber

Affiliate Researcher
Titles and Affiliations
Assistant Professor, Biology

In the Huber lab, we are driven to understand how evolutionary mechanisms such as mutation, recombination, and natural selection shape genetic diversity and the variability between individuals and species.

We develop novel population genetic and machine learning methods for detecting and understanding adaption in plants and animals. Sequencing thousands of years old human remains allows us to investigate how environmental pressures and lifestyle changes have shaped our own genomes.

Our research has important implications for the preservation and protection of endangered species and for understanding genetic disorders.

In the News

Research Keywords

 These keywords and phrases come from the publications and other research output of this person. See other researchers related to these topics by clicking on any keyword.

Recent Publications

Fluctuating selection and the determinants of genetic variation

Johnson, O. L., Tobler, R., Schmidt, J. M. & Huber, C. D., Jun 2023, In: Trends in Genetics. 39, 6, p. 491-504 14 p.

Research output: Contribution to journalReview articlepeer-review

Standing genetic variation fuels rapid evolution of herbicide resistance in blackgrass

Kersten, S., Chang, J., Huber, C. D., Voichek, Y., Lanz, C., Hagmaier, T., Lang, P., Lutz, U., Hirschberg, I., Lerchl, J., Porri, A., Van de Peer, Y., Schmid, K., Weigel, D. & Rabanal, F. A., Apr 18 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 16, e2206808120.

Research output: Contribution to journalArticlepeer-review

CATE: A fast and scalable CUDA implementation to conduct highly parallelized evolutionary tests on large scale genomic data

Perera, D., Reisenhofer, E., Hussein, S., Higgins, E., Huber, C. D. & Long, Q., Aug 2023, In: Methods in Ecology and Evolution. 14, 8, p. 2095-2109 15 p.

Research output: Contribution to journalArticlepeer-review

The role of genetic selection and climatic factors in the dispersal of anatomically modern humans out of Africa

Tobler, R., Souilmi, Y., Huber, C. D., Bean, N., Turney, C. S. M., Grey, S. T. & Cooper, A., May 30 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 22, e2213061120.

Research output: Contribution to journalArticlepeer-review

Admixture has obscured signals of historical hard sweeps in humans

Souilmi, Y., Tobler, R., Johar, A., Williams, M., Grey, S. T., Schmidt, J., Teixeira, J. C., Rohrlach, A., Tuke, J., Johnson, O., Gower, G., Turney, C., Cox, M., Cooper, A. & Huber, C. D., Dec 2022, In: Nature Ecology and Evolution. 6, 12, p. 2003-2015 13 p.

Research output: Contribution to journalArticlepeer-review

The biasing impact of irrelevant contextual information on forensic odontology radiograph matching decisions

Chiam, S. L., Dror, I. E., Huber, C. D. & Higgins, D., Oct 2021, In: Forensic science international. 327, 110997.

Research output: Contribution to journalArticlepeer-review

Quantifying the evolutionary constraints and potential of hepatitis c virus ns5a protein

Dai, L., Du, Y., Qi, H., Huber, C. D., Chen, D., Zhang, T. H., Wu, N. C., Wang, E., Lloyd-Smith, J. O. & Sun, R., 2021, In: mSystems. 6, 2, e01111-20.

Research output: Contribution to journalArticlepeer-review

smartsnp, an r package for fast multivariate analyses of big genomic data

Herrando-Pérez, S., Tobler, R. & Huber, C. D., Nov 2021, In: Methods in Ecology and Evolution. 12, 11, p. 2084-2093 10 p.

Research output: Contribution to journalArticlepeer-review

An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia

Souilmi, Y., Lauterbur, M. E., Tobler, R., Huber, C. D., Johar, A. S., Moradi, S. V., Johnston, W. A., Krogan, N. J., Alexandrov, K. & Enard, D., Aug 23 2021, In: Current Biology. 31, 16, p. 3504-3514.e9

Research output: Contribution to journalArticlepeer-review

Erratum: “An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia” (Current Biology (2021) 31(16) (3504–3514.e9), (S0960982221007946), (10.1016/j.cub.2021.05.067))

Souilmi, Y., Lauterbur, M. E., Tobler, R., Huber, C. D., Johar, A. S., Moradi, S. V., Johnston, W. A., Krogan, N. J., Alexandrov, K. & Enard, D., Aug 23 2021, In: Current Biology. 31, 16, p. 3704 1 p.

Research output: Contribution to journalComment/debatepeer-review

Authors’ Reply to Letter to the Editor: Neutral genetic diversity as a useful tool for conservation biology

Teixeira, J. C. & Huber, C. D., Aug 2021, In: Conservation Genetics. 22, 4, p. 547-549 3 p.

Research output: Contribution to journalLetterpeer-review

The inflated significance of neutral genetic diversity in conservation genetics

Teixeira, J. C. & Huber, C. D., Mar 9 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 10, e2015096118.

Research output: Contribution to journalReview articlepeer-review

Greater strength of selection and higher proportion of beneficial amino acid changing mutations in humans compared with mice and Drosophila melanogaster

Zhen, Y., Huber, C. D., Davies, R. W. & Lohmueller, K. E., Jan 2021, In: Genome research. 31, 1, p. 110-120 11 p.

Research output: Contribution to journalArticlepeer-review

Population genetic models of GERP scores suggest pervasive turnover of constrained sites across mammalian evolution

Huber, C. D., Kim, B. Y. & Lohmueller, K. E., May 2020, In: PLoS genetics. 16, 5, e1008827.

Research output: Contribution to journalArticlepeer-review

A-to-I RNA editing uncovers hidden signals of adaptive genome evolution in animals

Popitsch, N., Huber, C. D., Buchumenski, I., Eisenberg, E., Jantsch, M., von Haeseler, A. & Gallach, M., 2020, In: Genome biology and evolution. 12, 4, p. 345-357 13 p.

Research output: Contribution to journalArticlepeer-review