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Christian Huber

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Email
cdh5313@psu.edu

512 Mueller Lab
University Park, PA 16802

Elsevier Pure Profile
IEE Research Themes
Climate and Natural Systems
Health and the Environment
Affiliate Researcher
Titles and Affiliations
Assistant Professor, Biology

In the Huber lab, we are driven to understand how evolutionary mechanisms such as mutation, recombination, and natural selection shape genetic diversity and the variability between individuals and species.

We develop novel population genetic and machine learning methods for detecting and understanding adaption in plants and animals. Sequencing thousands of years old human remains allows us to investigate how environmental pressures and lifestyle changes have shaped our own genomes.

Our research has important implications for the preservation and protection of endangered species and for understanding genetic disorders.

In the News

Research Keywords

 These keywords and phrases come from the publications and other research output of this person. See other researchers related to these topics by clicking on any keyword.

Evolution
Genetic Divergence
Genomics
Population Genetics
Genetic Variation
Natural Population
Drosophila Melanogaster
Genetics
Natural Selection
Natural Populations
Background Selection
Selective Sweep
Non-synonymous Mutation
Across Species
Gene Flow
Genealogical Tree
Evolutionary
Genomic Data
Coronavirus
East Asia

Recent Publications

A likelihood-based framework for demographic inference from genealogical trees

Fan, C., Cahoon, J. L., Dinh, B. L., Ortega-Del Vecchyo, D., Huber, C. D., Edge, M. D., Mancuso, N. & Chiang, C. W. K., Apr 2025, In: Nature Genetics. 57, 4, p. 865-874 10 p., 280.

Research output: Contribution to journal › Article › peer-review

Correction to: A likelihood-based framework for demographic inference from genealogical trees (Nature Genetics, (2025), 57, 4, (865-874), 10.1038/s41588-025-02129-x)

Fan, C., Cahoon, J. L., Dinh, B. L., Ortega-Del Vecchyo, D., Huber, C. D., Edge, M. D., Mancuso, N. & Chiang, C. W. K., Jul 2025, In: Nature Genetics. 57, 7, p. 1787 1 p.

Research output: Contribution to journal › Comment/debate › peer-review

Performance of qpAdm-based screens for genetic admixture on graph-shaped histories and stepping stone landscapes

Flegontova, O., Işlldak, U., Yüncü, E., Williams, M. P., Huber, C. D., Kočí, J., Vyazov, L. A., Changmai, P. & Flegontov, P., May 1 2025, In: Genetics. 230, 1, iyaf047.

Research output: Contribution to journal › Article › peer-review

Modeling the European Neolithic expansion suggests predominant within-group mating and limited cultural transmission

LaPolice, T. M., Williams, M. P. & Huber, C. D., Dec 2025, In: Nature communications. 16, 1, 7905.

Research output: Contribution to journal › Article › peer-review

Apollo: a comprehensive GPU-powered within-host simulator for viral evolution and infection dynamics across population, tissue, and cell

Perera, D., Li, E., Gordon, P. M. K., van der Meer, F., Lynch, T., Gill, J., Church, D. L., de Koning, A. P. J., Huber, C. D., van Marle, G., Platt, A. & Long, Q., Dec 2025, In: Nature communications. 16, 1, 5783.

Research output: Contribution to journal › Article › peer-review

The genomic footprints of migration: how ancient DNA reveals our history of mobility

Williams, M. P. & Huber, C. D., Dec 2025, In: Genome biology. 26, 1, 206.

Research output: Contribution to journal › Review article › peer-review

Complete sequencing of ape genomes

Yoo, D. A., Rhie, A., Hebbar, P., Antonacci, F., Logsdon, G. A., Solar, S. J., Antipov, D., Pickett, B. D., Safonova, Y., Montinaro, F., Luo, Y., Malukiewicz, J., Storer, J. M., Lin, J., Sequeira, A. N., Mangan, R. J., Hickey, G., Monfort Anez, G., Balachandran, P. & Bankevich, A. & 103 others, Beck, C. R., Biddanda, A., Borchers, M., Bouffard, G. G., Brannan, E., Brooks, S. Y., Carbone, L., Carrel, L., Chan, A. P., Crawford, J., Diekhans, M., Engelbrecht, E., Feschotte, C., Formenti, G., Garcia, G. H., de Gennaro, L., Gilbert, D., Green, R. E., Guarracino, A., Gupta, I., Haddad, D., Han, J., Harris, R. S., Hartley, G. A., Harvey, W. T., Hiller, M., Hoekzema, K., Houck, M. L., Jeong, H., Kamali, K., Kellis, M., Kille, B., Lee, C., Lee, Y., Lees, W., Lewis, A. P., Li, Q., Loftus, M., Loh, Y. H. E., Loucks, H., Ma, J., Mao, Y., Martinez, J. F. I., Masterson, P., McCoy, R. C., McGrath, B., McKinney, S., Meyer, B. S., Miga, K. H., Mohanty, S. K., Munson, K. M., Pal, K., Pennell, M., Pevzner, P. A., Porubsky, D., Potapova, T., Ringeling, F. R., Rocha, J. L., Ryder, O. A., Sacco, S., Saha, S., Sasaki, T., Schatz, M. C., Schork, N. J., Shanks, C., Smeds, L., Son, D. R., Steiner, C., Sweeten, A. P., Tassia, M. G., Thibaud-Nissen, F., Torres-González, E., Trivedi, M., Wei, W., Wertz, J., Yang, M., Zhang, P., Zhang, S., Zhang, Y., Zhang, Z., Zhao, S. A., Zhu, Y., Jarvis, E. D., Gerton, J. L., Rivas-González, I., Paten, B., Szpiech, Z. A., Huber, C. D., Lenz, T. L., Konkel, M. K., Yi, S. V., Canzar, S., Watson, C. T., Sudmant, P. H., Molloy, E., Garrison, E., Lowe, C. B., Ventura, M., O’Neill, R. J., Koren, S., Makova, K. D., Phillippy, A. M. & Eichler, E. E., May 8 2025, In: Nature. 641, 8062, p. 401-418 18 p.

Research output: Contribution to journal › Article › peer-review

The Promise of Inferring the Past Using the Ancestral Recombination Graph

Brandt, D. Y. C., Huber, C. D., Chiang, C. W. K. & Vecchyo, D. O. D., Feb 1 2024, In: Genome biology and evolution. 16, 2, evae005.

Research output: Contribution to journal › Review article › peer-review

Population genetic simulation: Benchmarking frameworks for non-standard models of natural selection

Johnson, O. L., Tobler, R., Schmidt, J. M. & Huber, C. D., Apr 2024, In: Molecular Ecology Resources. 24, 3, e13930.

Research output: Contribution to journal › Article › peer-review

The complete sequence and comparative analysis of ape sex chromosomes

Makova, K. D., Pickett, B. D., Harris, R. S., Hartley, G. A., Cechova, M., Pal, K., Nurk, S., Yoo, D. A., Li, Q., Hebbar, P., McGrath, B. C., Antonacci, F., Aubel, M., Biddanda, A., Borchers, M., Bornberg-Bauer, E., Bouffard, G. G., Brooks, S. Y., Carbone, L. & Carrel, L. & 64 others, Carroll, A., Chang, P. C., Chin, C. S., Cook, D. E., Craig, S. J. C., de Gennaro, L., Diekhans, M., Dutra, A., Garcia, G. H., Grady, P. G. S., Green, R. E., Haddad, D., Hallast, P., Harvey, W. T., Hickey, G., Hillis, D. A., Hoyt, S. J., Jeong, H., Kamali, K., Pond, S. L. K., LaPolice, T. M., Lee, C., Lewis, A. P., Loh, Y. H. E., Masterson, P., McGarvey, K. M., McCoy, R. C., Medvedev, P., Miga, K. H., Munson, K. M., Pak, E., Paten, B., Pinto, B. J., Potapova, T., Rhie, A., Rocha, J. L., Ryabov, F., Ryder, O. A., Sacco, S., Shafin, K., Shepelev, V. A., Slon, V., Solar, S. J., Storer, J. M., Sudmant, P. H., Sweetalana, Sweeten, A., Tassia, M. G., Thibaud-Nissen, F., Ventura, M., Wilson, M. A., Young, A. C., Zeng, H., Zhang, X., Szpiech, Z. A., Huber, C. D., Gerton, J. L., Yi, S. V., Schatz, M. C., Alexandrov, I. A., Koren, S., O’Neill, R. J., Eichler, E. E. & Phillippy, A. M., Jun 13 2024, In: Nature. 630, 8016, p. 401-411 11 p.

Research output: Contribution to journal › Article › peer-review

Testing times: Disentangling admixture histories in recent and complex demographies using ancient DNA

Williams, M. P., Flegontov, P., Maier, R. & Huber, C. D., Sep 1 2024, In: Genetics. 228, 1, iyae110.

Research output: Contribution to journal › Article › peer-review

Fluctuating selection and the determinants of genetic variation

Johnson, O. L., Tobler, R., Schmidt, J. M. & Huber, C. D., Jun 2023, In: Trends in Genetics. 39, 6, p. 491-504 14 p.

Research output: Contribution to journal › Review article › peer-review

Standing genetic variation fuels rapid evolution of herbicide resistance in blackgrass

Kersten, S., Chang, J., Huber, C. D., Voichek, Y., Lanz, C., Hagmaier, T., Lang, P., Lutz, U., Hirschberg, I., Lerchl, J., Porri, A., Van de Peer, Y., Schmid, K., Weigel, D. & Rabanal, F. A., Apr 18 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 16, e2206808120.

Research output: Contribution to journal › Article › peer-review

CATE: A fast and scalable CUDA implementation to conduct highly parallelized evolutionary tests on large scale genomic data

Perera, D., Reisenhofer, E., Hussein, S., Higgins, E., Huber, C. D. & Long, Q., Aug 2023, In: Methods in Ecology and Evolution. 14, 8, p. 2095-2109 15 p.

Research output: Contribution to journal › Article › peer-review

The role of genetic selection and climatic factors in the dispersal of anatomically modern humans out of Africa

Tobler, R., Souilmi, Y., Huber, C. D., Bean, N., Turney, C. S. M., Grey, S. T. & Cooper, A., May 30 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 22, e2213061120.

Research output: Contribution to journal › Article › peer-review