In the Huber lab, we are driven to understand how evolutionary mechanisms such as mutation, recombination, and natural selection shape genetic diversity and the variability between individuals and species.
We develop novel population genetic and machine learning methods for detecting and understanding adaption in plants and animals. Sequencing thousands of years old human remains allows us to investigate how environmental pressures and lifestyle changes have shaped our own genomes.
Our research has important implications for the preservation and protection of endangered species and for understanding genetic disorders.
In the News
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Recent Publications
The Promise of Inferring the Past Using the Ancestral Recombination Graph
Brandt, D. Y. C., Huber, C. D., Chiang, C. W. K. & Vecchyo, D. O. D., Feb 1 2024, In: Genome biology and evolution. 16, 2, evae005.Research output: Contribution to journal › Review article › peer-review
Population genetic simulation: Benchmarking frameworks for non-standard models of natural selection
Johnson, O. L., Tobler, R., Schmidt, J. M. & Huber, C. D., Apr 2024, In: Molecular Ecology Resources. 24, 3, e13930.Research output: Contribution to journal › Article › peer-review
The complete sequence and comparative analysis of ape sex chromosomes
Makova, K. D., Pickett, B. D., Harris, R. S., Hartley, G. A., Cechova, M., Pal, K., Nurk, S., Yoo, D. A., Li, Q., Hebbar, P., McGrath, B. C., Antonacci, F., Aubel, M., Biddanda, A., Borchers, M., Bornberg-Bauer, E., Bouffard, G. G., Brooks, S. Y., Carbone, L. & Carrel, L. & 64 others, , Jun 13 2024, In: Nature. 630, 8016, p. 401-411 11 p.Research output: Contribution to journal › Article › peer-review
Fluctuating selection and the determinants of genetic variation
Johnson, O. L., Tobler, R., Schmidt, J. M. & Huber, C. D., Jun 2023, In: Trends in Genetics. 39, 6, p. 491-504 14 p.Research output: Contribution to journal › Review article › peer-review
Standing genetic variation fuels rapid evolution of herbicide resistance in blackgrass
Kersten, S., Chang, J., Huber, C. D., Voichek, Y., Lanz, C., Hagmaier, T., Lang, P., Lutz, U., Hirschberg, I., Lerchl, J., Porri, A., Van de Peer, Y., Schmid, K., Weigel, D. & Rabanal, F. A., Apr 18 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 16, e2206808120.Research output: Contribution to journal › Article › peer-review
CATE: A fast and scalable CUDA implementation to conduct highly parallelized evolutionary tests on large scale genomic data
Perera, D., Reisenhofer, E., Hussein, S., Higgins, E., Huber, C. D. & Long, Q., Aug 2023, In: Methods in Ecology and Evolution. 14, 8, p. 2095-2109 15 p.Research output: Contribution to journal › Article › peer-review
The role of genetic selection and climatic factors in the dispersal of anatomically modern humans out of Africa
Tobler, R., Souilmi, Y., Huber, C. D., Bean, N., Turney, C. S. M., Grey, S. T. & Cooper, A., May 30 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 22, e2213061120.Research output: Contribution to journal › Article › peer-review
Admixture has obscured signals of historical hard sweeps in humans
Souilmi, Y., Tobler, R., Johar, A., Williams, M., Grey, S. T., Schmidt, J., Teixeira, J. C., Rohrlach, A., Tuke, J., Johnson, O., Gower, G., Turney, C., Cox, M., Cooper, A. & Huber, C. D., Dec 2022, In: Nature Ecology and Evolution. 6, 12, p. 2003-2015 13 p.Research output: Contribution to journal › Article › peer-review
The biasing impact of irrelevant contextual information on forensic odontology radiograph matching decisions
Chiam, S. L., Dror, I. E., Huber, C. D. & Higgins, D., Oct 2021, In: Forensic science international. 327, 110997.Research output: Contribution to journal › Article › peer-review
Quantifying the evolutionary constraints and potential of hepatitis c virus ns5a protein
Dai, L., Du, Y., Qi, H., Huber, C. D., Chen, D., Zhang, T. H., Wu, N. C., Wang, E., Lloyd-Smith, J. O. & Sun, R., 2021, In: mSystems. 6, 2, e01111-20.Research output: Contribution to journal › Article › peer-review
smartsnp, an r package for fast multivariate analyses of big genomic data
Herrando-Pérez, S., Tobler, R. & Huber, C. D., Nov 2021, In: Methods in Ecology and Evolution. 12, 11, p. 2084-2093 10 p.Research output: Contribution to journal › Article › peer-review
An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia
Souilmi, Y., Lauterbur, M. E., Tobler, R., Huber, C. D., Johar, A. S., Moradi, S. V., Johnston, W. A., Krogan, N. J., Alexandrov, K. & Enard, D., Aug 23 2021, In: Current Biology. 31, 16, p. 3504-3514.e9Research output: Contribution to journal › Article › peer-review
Erratum: “An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia” (Current Biology (2021) 31(16) (3504–3514.e9), (S0960982221007946), (10.1016/j.cub.2021.05.067))
Souilmi, Y., Lauterbur, M. E., Tobler, R., Huber, C. D., Johar, A. S., Moradi, S. V., Johnston, W. A., Krogan, N. J., Alexandrov, K. & Enard, D., Aug 23 2021, In: Current Biology. 31, 16, p. 3704 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Authors’ Reply to Letter to the Editor: Neutral genetic diversity as a useful tool for conservation biology
Teixeira, J. C. & Huber, C. D., Aug 2021, In: Conservation Genetics. 22, 4, p. 547-549 3 p.Research output: Contribution to journal › Letter › peer-review
The inflated significance of neutral genetic diversity in conservation genetics
Teixeira, J. C. & Huber, C. D., Mar 9 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 10, e2015096118.Research output: Contribution to journal › Review article › peer-review