Research Summary
Ecology and evolution of infectious disease. We exploit modern notions of adaptive evolution to attack biomedically and theoretically challenging phenomena like virulence and infectiousness, adaptation to new hosts, vaccine escape, and drug and insecticide resistance. Our work involves evolutionary biology, ecology, parasitology, microbiology, genetics, and immunology. Currently, much of the work concerns the three players that cause malaria (the parasite, the vertebrate host, and the mosquito), as well entomopathogenic fungi and Marek’s disease of chickens. In the past, we also have worked on the parasites of Daphnia, African trypanosomes, and parasitic nematodes of mammals.
In the News
Research Keywords
These keywords and phrases come from the publications and other research output of this person. See other researchers related to these topics by clicking on any keyword.
Recent Publications
Combination antimicrobial therapy to manage resistance
Woods, R. J. & Read, A. F., 2023, In: Evolution, Medicine and Public Health. 11, 1, p. 185-186 2 p.Research output: Contribution to journal › Article › peer-review
The evolution of antibiotic resistance in an incurable and ultimately fatal infection: A retrospective case study
Woods, R. J., Barbosa, C., Koepping, L., Raygoza, J. A., Mwangi, M. & Read, A. F., 2023, In: Evolution, Medicine and Public Health. 11, 1, p. 163-173 11 p.Research output: Contribution to journal › Article › peer-review
A longitudinal study of the impact of university student return to campus on the SARS-CoV-2 seroprevalence among the community members
Arnold, C. R. K., Srinivasan, S., Rodriguez, S., Rydzak, N., Herzog, C. M., Gontu, A., Bharti, N., Small, M., Rogers, C. J., Schade, M. M., Kuchipudi, S. V., Kapur, V., Read, A. F. & Ferrari, M. J., Dec 2022, In: Scientific reports. 12, 1, 8586.Research output: Contribution to journal › Article › peer-review
Pathogen evolution during vaccination campaigns
Day, T., Kennedy, D. A., Read, A. F. & Gandon, S., Sep 1 2022, In: PLoS biology. 20, 9, p. e3001804Research output: Contribution to journal › Article › peer-review
Impacts of the COVID-19 pandemic on pharmaceuticals in wastewater treated for beneficial reuse: Two case studies in central Pennsylvania
Hayden, K. R., Jones, M., Elkin, K. R., Shreve, M. J., Clees, W. I., Clark, S., Mashtare, M. L., Veith, T. L., Elliott, H. A., Watson, J. E., Silverman, J., Richard, T. L., Read, A. F. & Preisendanz, H. E., Sep 1 2022, In: Journal of Environmental Quality. 51, 5, p. 1066-1082 17 p.Research output: Contribution to journal › Article › peer-review
Divergent Evolutionary Pathways of Myxoma Virus in Australia: Virulence Phenotypes in Susceptible and Partially Resistant Rabbits Indicate Possible Selection for Transmissibility
Kerr, P. J., Cattadori, I. M., Sim, D., Liu, J., Holmes, E. C. & Read, A. F., Oct 2022, In: Journal of virology. 96, 20Research output: Contribution to journal › Article › peer-review
An orally administered drug prevents selection for antibiotic-resistant bacteria in the gut during daptomycin therapy
Morley, V. J., Sim, D. G., Penkevich, A., Woods, R. J. & Read, A. F., 2022, In: Evolution, Medicine and Public Health. 10, 1, p. 439-446 8 p.Research output: Contribution to journal › Article › peer-review
Ion Exchange Biomaterials to Capture Daptomycin and Prevent Resistance Evolution in Off-Target Bacterial Populations
Yeh, S. L., Narasimhalu, N., Vom Steeg, L. G., Muthami, J., Leconey, S., He, Z., Pitcher, M., Cassady, H., Morley, V. J., Cho, S. H., Bator, C., Koshani, R., Woods, R. J., Hickner, M., Read, A. F. & Sheikhi, A., Sep 28 2022, In: ACS Applied Materials and Interfaces. 14, 38, p. 42864-42875 12 p.Research output: Contribution to journal › Article › peer-review
The economics of managing evolution
Day, T., Kennedy, D. A., Read, A. F. & McAdams, D., Nov 2021, In: PLoS biology. 19, 11, e3001409.Research output: Contribution to journal › Article › peer-review
Effect of drug dose and timing of treatment on the emergence of drug resistance in vivo in a malaria model
Acosta, M. M., Bram, J. T., Sim, D. & Read, A. F., 2020, In: Evolution, Medicine and Public Health. 2020, 1, p. 196-210 15 p.Research output: Contribution to journal › Article › peer-review
Identifying key questions in the ecology and evolution of cancer
Dujon, A. M., Aktipis, A., Alix-Panabières, C., Amend, S. R., Boddy, A. M., Brown, J. S., Capp, J. P., DeGregori, J., Ewald, P., Gatenby, R., Gerlinger, M., Giraudeau, M., Hamede, R. K., Hansen, E., Kareva, I., Maley, C. C., Marusyk, A., McGranahan, N., Metzger, M. J., Nedelcu, A. M., & 13 others, 2020, (Accepted/In press) In: Evolutionary Applications. 14, 4, p. 877-892 16 p.Research output: Contribution to journal › Article › peer-review
Evolutionary consequences of feedbacks between within-host competition and disease control
Greischar, M. A., Alexander, H. K., Bashey, F., Bento, A. I., Bhattacharya, A., Bushman, M., Childs, L. M., Daversa, D. R., Day, T., Faust, C. L., Gallagher, M. E., Gandon, S., Glidden, C. K., Halliday, F. W., Hanley, K. A., Kamiya, T., Read, A. F., Schwabl, P., Sweeny, A. R., Tate, A. T., & 5 others, Mar 3 2020, In: Evolution, Medicine and Public Health. 2020, 1, p. 30-34 5 p.Research output: Contribution to journal › Article › peer-review
Antibiotics can be used to contain drug-resistant bacteria by maintaining sufficiently large sensitive populations
Hansen, E., Karslake, J., Woods, R. J., Read, A. F. & Wood, K. B., May 2020, In: PLoS biology. 18, 5, e3000713.Research output: Contribution to journal › Article › peer-review
Cancer therapy: Attempt cure or manage drug resistance?
Hansen, E. & Read, A. F., Aug 1 2020, In: Evolutionary Applications. 13, 7, p. 1660-1672 13 p.Research output: Contribution to journal › Article › peer-review
Modifying adaptive therapy to enhance competitive suppression
Hansen, E. & Read, A. F., Dec 2020, In: Cancers. 12, 12, p. 1-13 13 p., 3556.Research output: Contribution to journal › Article › peer-review