
Research Summary
Ecology and evolution of infectious disease. We exploit modern notions of adaptive evolution to attack biomedically and theoretically challenging phenomena like virulence and infectiousness, adaptation to new hosts, vaccine escape, and drug and insecticide resistance. Our work involves evolutionary biology, ecology, parasitology, microbiology, genetics, and immunology. Currently, much of the work concerns the three players that cause malaria (the parasite, the vertebrate host, and the mosquito), as well entomopathogenic fungi and Marek’s disease of chickens. In the past, we also have worked on the parasites of Daphnia, African trypanosomes, and parasitic nematodes of mammals.In the News
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Recent Publications
Effect of drug dose and timing of treatment on the emergence of drug resistance in vivo in a malaria model
Acosta, M. M., Bram, J. T., Sim, D. & Read, A. F., 2020, In: Evolution, Medicine and Public Health. 2020, 1, p. 196-210 15 p.Research output: Contribution to journal › Article › peer-review
Identifying key questions in the ecology and evolution of cancer
Dujon, A. M., Aktipis, A., Alix-Panabières, C., Amend, S. R., Boddy, A. M., Brown, J. S., Capp, J. P., DeGregori, J., Ewald, P., Gatenby, R., Gerlinger, M., Giraudeau, M., Hamede, R. K., Hansen, E., Kareva, I., Maley, C. C., Marusyk, A., McGranahan, N., Metzger, M. J., Nedelcu, A. M. & 13 others, , 2020, (Accepted/In press) In: Evolutionary Applications. 14, 4, p. 877-892 16 p.Research output: Contribution to journal › Article › peer-review
Evolutionary consequences of feedbacks between within-host competition and disease control
Greischar, M. A., Alexander, H. K., Bashey, F., Bento, A. I., Bhattacharya, A., Bushman, M., Childs, L. M., Daversa, D. R., Day, T., Faust, C. L., Gallagher, M. E., Gandon, S., Glidden, C. K., Halliday, F. W., Hanley, K. A., Kamiya, T., Read, A. F., Schwabl, P., Sweeny, A. R., Tate, A. T. & 5 others, , Mar 3 2020, In: Evolution, Medicine and Public Health. 2020, 1, p. 30-34 5 p.Research output: Contribution to journal › Article › peer-review
Antibiotics can be used to contain drug-resistant bacteria by maintaining sufficiently large sensitive populations
Hansen, E., Karslake, J., Woods, R. J., Read, A. F. & Wood, K. B., May 2020, In: PLoS biology. 18, 5, e3000713.Research output: Contribution to journal › Article › peer-review
Cancer therapy: Attempt cure or manage drug resistance?
Hansen, E. & Read, A. F., Aug 1 2020, In: Evolutionary Applications. 13, 7, p. 1660-1672 13 p.Research output: Contribution to journal › Article › peer-review
Modifying adaptive therapy to enhance competitive suppression
Hansen, E. & Read, A. F., Dec 2020, In: Cancers. 12, 12, p. 1-13 13 p., 3556.Research output: Contribution to journal › Article › peer-review
Monitor for COVID-19 vaccine resistance evolution during clinical trials
Kennedy, D. A., Read, A. F. & Kennedy, D. A., Nov 9 2020, In: PLoS biology. 18, 11, e3001000.Research output: Contribution to journal › Article › peer-review
Daptomycin treatment impacts resistance in off-target populations of vancomycin-resistant Enterococcus faecium
Kinnear, C. L., Hansen, E., Morley, V. J., Tracy, K. C., Forstchen, M., Read, A. F. & Woods, R. J., Dec 17 2020, (E-pub ahead of print) In: PLoS biology. 18, 12, p. e3000987Research output: Contribution to journal › Article › peer-review
Daptomycin treatment impacts resistance in off-target populations of vancomycin-resistant Enterococcus faecium
Kinnear, C. L., Hansen, E., Morley, V. J., Tracy, K. C., Forstchen, M., Read, A. F. & Woods, R. J., Dec 17 2020, In: PLoS biology. 18, 12 December, e3000987.Research output: Contribution to journal › Article › peer-review
An adjunctive therapy administered with an antibiotic prevents enrichment of antibiotic-resistant clones of a colonizing opportunistic pathogen
Morley, V. J., Kinnear, C. L., Sim, D. G., Olson, S. N., Jackson, L. M., Hansen, E., Usher, G. A., Showalter, S. A., Pai, M. P., Woods, R. J. & Read, A. F., Dec 1 2020, In: eLife. 9, p. 1-17 17 p., e58147.Research output: Contribution to journal › Article › peer-review