Andrew Read

Profile Photo
Image
Email
IEE Research Themes
Affiliate Researcher
Titles and Affiliations
Evan Pugh Professor of Biology and Entomology, Eberly Professor of Biotechnology, Biology
Director, Huck Institutes of the Life Sciences

Research Summary

Ecology and evolution of infectious disease. We exploit modern notions of adaptive evolution to attack biomedically and theoretically challenging phenomena like virulence and infectiousness, adaptation to new hosts, vaccine escape, and drug and insecticide resistance. Our work involves evolutionary biology, ecology, parasitology, microbiology, genetics, and immunology. Currently, much of the work concerns the three players that cause malaria (the parasite, the vertebrate host, and the mosquito), as well entomopathogenic fungi and Marek’s disease of chickens. In the past, we also have worked on the parasites of Daphnia, African trypanosomes, and parasitic nematodes of mammals.

In the News

Research Keywords

 These keywords and phrases come from the publications and other research output of this person. See other researchers related to these topics by clicking on any keyword.

Recent Publications

Effect of drug dose and timing of treatment on the emergence of drug resistance in vivo in a malaria model

Acosta, M. M., Bram, J. T., Sim, D. & Read, A. F., 2020, In: Evolution, Medicine and Public Health. 2020, 1, p. 196-210 15 p.

Research output: Contribution to journalArticlepeer-review

Identifying key questions in the ecology and evolution of cancer

Dujon, A. M., Aktipis, A., Alix-Panabières, C., Amend, S. R., Boddy, A. M., Brown, J. S., Capp, J. P., DeGregori, J., Ewald, P., Gatenby, R., Gerlinger, M., Giraudeau, M., Hamede, R. K., Hansen, E., Kareva, I., Maley, C. C., Marusyk, A., McGranahan, N., Metzger, M. J., Nedelcu, A. M. & 13 others, Noble, R., Nunney, L., Pienta, K. J., Polyak, K., Pujol, P., Read, A. F., Roche, B., Sebens, S., Solary, E., Staňková, K., Swain Ewald, H., Thomas, F. & Ujvari, B., 2020, (Accepted/In press) In: Evolutionary Applications. 14, 4, p. 877-892 16 p.

Research output: Contribution to journalArticlepeer-review

Evolutionary consequences of feedbacks between within-host competition and disease control

Greischar, M. A., Alexander, H. K., Bashey, F., Bento, A. I., Bhattacharya, A., Bushman, M., Childs, L. M., Daversa, D. R., Day, T., Faust, C. L., Gallagher, M. E., Gandon, S., Glidden, C. K., Halliday, F. W., Hanley, K. A., Kamiya, T., Read, A. F., Schwabl, P., Sweeny, A. R., Tate, A. T. & 5 others, Thompson, R. N., Wale, N., Wearing, H. J., Yeh, P. J. & Mideo, N., Mar 3 2020, In: Evolution, Medicine and Public Health. 2020, 1, p. 30-34 5 p.

Research output: Contribution to journalArticlepeer-review

Antibiotics can be used to contain drug-resistant bacteria by maintaining sufficiently large sensitive populations

Hansen, E., Karslake, J., Woods, R. J., Read, A. F. & Wood, K. B., May 2020, In: PLoS biology. 18, 5, e3000713.

Research output: Contribution to journalArticlepeer-review

Cancer therapy: Attempt cure or manage drug resistance?

Hansen, E. & Read, A. F., Aug 1 2020, In: Evolutionary Applications. 13, 7, p. 1660-1672 13 p.

Research output: Contribution to journalArticlepeer-review

Modifying adaptive therapy to enhance competitive suppression

Hansen, E. & Read, A. F., Dec 2020, In: Cancers. 12, 12, p. 1-13 13 p., 3556.

Research output: Contribution to journalArticlepeer-review

Monitor for COVID-19 vaccine resistance evolution during clinical trials

Kennedy, D. A., Read, A. F. & Kennedy, D. A., Nov 9 2020, In: PLoS biology. 18, 11, e3001000.

Research output: Contribution to journalArticlepeer-review

Daptomycin treatment impacts resistance in off-target populations of vancomycin-resistant Enterococcus faecium

Kinnear, C. L., Hansen, E., Morley, V. J., Tracy, K. C., Forstchen, M., Read, A. F. & Woods, R. J., Dec 17 2020, (E-pub ahead of print) In: PLoS biology. 18, 12, p. e3000987

Research output: Contribution to journalArticlepeer-review

Daptomycin treatment impacts resistance in off-target populations of vancomycin-resistant Enterococcus faecium

Kinnear, C. L., Hansen, E., Morley, V. J., Tracy, K. C., Forstchen, M., Read, A. F. & Woods, R. J., Dec 17 2020, In: PLoS biology. 18, 12 December, e3000987.

Research output: Contribution to journalArticlepeer-review

An adjunctive therapy administered with an antibiotic prevents enrichment of antibiotic-resistant clones of a colonizing opportunistic pathogen

Morley, V. J., Kinnear, C. L., Sim, D. G., Olson, S. N., Jackson, L. M., Hansen, E., Usher, G. A., Showalter, S. A., Pai, M. P., Woods, R. J. & Read, A. F., Dec 1 2020, In: eLife. 9, p. 1-17 17 p., e58147.

Research output: Contribution to journalArticlepeer-review