William Hancock

Affiliate Researcher
Titles and Affiliations
Professor, Biomedical Engineering

In the News

Research Keywords

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Recent Publications

Lignin impairs Cel7A degradation of in vitro lignified cellulose by impeding enzyme movement and not by acting as a sink

Haviland, Z. K., Nong, D., Zexer, N., Tien, M., Anderson, C. T. & Hancock, W. O., Dec 2024, In: Biotechnology for Biofuels and Bioproducts. 17, 1, 7.

Research output: Contribution to journalArticlepeer-review

Simulations suggest robust microtubule attachment of kinesin and dynein in antagonistic pairs

Ma, T. C., Gicking, A. M., Feng, Q. & Hancock, W. O., Aug 22 2023, In: Biophysical journal. 122, 16, p. 3299-3313 15 p.

Research output: Contribution to journalArticlepeer-review

KIF1A is kinetically tuned to be a superengaging motor under hindering loads

Pyrpassopoulos, S., Gicking, A. M., Zaniewski, T. M., Hancock, W. O. & Ostap, E. M., Jan 10 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 2, e2216903120.

Research output: Contribution to journalArticlepeer-review

Positive charge in the K-loop of the kinesin-3 motor KIF1A regulates superprocessivity by enhancing microtubule affinity in the one-head–bound state

Zaniewski, T. M. & Hancock, W. O., Feb 2023, In: Journal of Biological Chemistry. 299, 2, 102818.

Research output: Contribution to journalArticlepeer-review

Measurements and simulations of microtubule growth imply strong longitudinal interactions and reveal a role for GDP on the elongating end

Cleary, J. M., Kim, T., Cook, A. S. I., McCormick, L. A., Hancock, W. O. & Rice, L. M., Apr 2022, In: eLife. 11, e75931.

Research output: Contribution to journalArticlepeer-review

Kinesin-1,-2, and-3 motors use family-specific mechanochemical strategies to effectively compete with dynein during bidirectional transport

Gicking, A. M., Ma, T. C., Feng, Q., Jiang, R., Badieyan, S., Cianfrocco, M. A. & Hancock, W. O., Sep 2022, In: eLife. 11, e82228.

Research output: Contribution to journalArticlepeer-review

Intracellular transport: KIF1C produces force along with a few slips

Hancock, W. O., Sep 12 2022, In: Current Biology. 32, 17, p. R914-R916

Research output: Contribution to journalComment/debatepeer-review

Synergy between inhibitors of two mitotic spindle assembly motors undermines an adaptive response

Solon, A. L., Zaniewski, T. M., O’Brien, P., Clasby, M., Hancock, W. O. & Ohi, R., Dec 1 2022, In: Molecular biology of the cell. 33, 14, ar132.

Research output: Contribution to journalArticlepeer-review

Measurement of the persistence length of cytoskeletal filaments using curvature distributions

Wisanpitayakorn, P., Mickolajczyk, K. J., Hancock, W. O., Vidali, L. & Tüzel, E., May 17 2022, In: Biophysical journal. 121, 10, p. 1813-1822 10 p.

Research output: Contribution to journalArticlepeer-review

Molecular mechanisms underlying microtubule growth dynamics

Cleary, J. M. & Hancock, W. O., May 24 2021, In: Current Biology. 31, 10, p. R560-R573

Research output: Contribution to journalReview articlepeer-review

Trim9 and Klp61F promote polymerization of new dendritic microtubules along parallel microtubules

Feng, C., Cleary, J. M., Kothe, G. O., Stone, M. C., Weiner, A. T., Hertzler, J. I., Hancock, W. O. & Rolls, M. M., Jun 2021, In: Journal of Cell Science. 134, 11, jcs258437.

Research output: Contribution to journalArticlepeer-review

Nanoscale dynamics of cellulose digestion by the cellobiohydrolase TrCel7A

Haviland, Z. K., Nong, D., Kuntz, K. L. V., Starr, T. J., Ma, D., Tien, M., Anderson, C. T. & Hancock, W. O., Sep 1 2021, In: Journal of Biological Chemistry. 297, 3, 101029.

Research output: Contribution to journalArticlepeer-review

A change point analysis protocol for comparing intracellular transport by different molecular motor combinations

Jensen, M. A., Feng, Q., Hancock, W. O. & McKinley, S. A., 2021, In: Mathematical Biosciences and Engineering. 18, 6, p. 8962-8996 35 p.

Research output: Contribution to journalArticlepeer-review

Measuring microtubule binding kinetics of membrane-bound kinesin motors using supported lipid bilayers

Jiang, R. & Hancock, W. O., Sep 17 2021, In: STAR Protocols. 2, 3, 100691.

Research output: Contribution to journalArticlepeer-review

Integrated multi-wavelength microscope combining TIRFM and IRM modalities for imaging cellulases and other processive enzymes

Nong, D., Haviland, Z. K., Kuntz, K. V., Tien, M., Anderson, C. T. & Hancock, W. O., Jun 1 2021, In: Biomedical Optics Express. 12, 6, p. 3253-3264 12 p.

Research output: Contribution to journalReview articlepeer-review