William Hancock

Affiliate Researcher
Titles and Affiliations
Professor, Biomedical Engineering

In the News

Research Keywords

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Recent Publications

Measurements and simulations of microtubule growth imply strong longitudinal interactions and reveal a role for GDP on the elongating end

Cleary, J. M., Kim, T., Cook, A. S. I., McCormick, L. A., Hancock, W. O. & Rice, L. M., Apr 2022, In: eLife. 11, e75931.

Research output: Contribution to journalArticlepeer-review

Measurement of the persistence length of cytoskeletal filaments using curvature distributions

Wisanpitayakorn, P., Mickolajczyk, K. J., Hancock, W. O., Vidali, L. & Tüzel, E., May 17 2022, In: Biophysical journal. 121, 10, p. 1813-1822 10 p.

Research output: Contribution to journalArticlepeer-review

Molecular mechanisms underlying microtubule growth dynamics

Cleary, J. M. & Hancock, W. O., May 24 2021, In: Current Biology. 31, 10, p. R560-R573

Research output: Contribution to journalReview articlepeer-review

Trim9 and Klp61F promote polymerization of new dendritic microtubules along parallel microtubules

Feng, C., Cleary, J. M., Kothe, G. O., Stone, M. C., Weiner, A. T., Hertzler, J. I., Hancock, W. O. & Rolls, M. M., Jun 2021, In: Journal of Cell Science. 134, 11, jcs258437.

Research output: Contribution to journalArticlepeer-review

Nanoscale dynamics of cellulose digestion by the cellobiohydrolase TrCel7A

Haviland, Z. K., Nong, D., Kuntz, K. L. V., Starr, T. J., Ma, D., Tien, M., Anderson, C. T. & Hancock, W. O., Sep 1 2021, In: Journal of Biological Chemistry. 297, 3, 101029.

Research output: Contribution to journalArticlepeer-review

A change point analysis protocol for comparing intracellular transport by different molecular motor combinations

Jensen, M. A., Feng, Q., Hancock, W. O. & McKinley, S. A., 2021, In: Mathematical Biosciences and Engineering. 18, 6, p. 8962-8996 35 p.

Research output: Contribution to journalArticlepeer-review

Measuring microtubule binding kinetics of membrane-bound kinesin motors using supported lipid bilayers

Jiang, R. & Hancock, W. O., Sep 17 2021, In: STAR Protocols. 2, 3, 100691.

Research output: Contribution to journalArticlepeer-review

Integrated multi-wavelength microscope combining TIRFM and IRM modalities for imaging cellulases and other processive enzymes

Nong, D., Haviland, Z. K., Kuntz, K. V., Tien, M., Anderson, C. T. & Hancock, W. O., Jun 1 2021, In: Biomedical Optics Express. 12, 6, p. 3253-3264 12 p.

Research output: Contribution to journalReview articlepeer-review

Dynactin p150 promotes processive motility of DDB complexes by minimizing diffusional behavior of dynein

Feng, Q., Gicking, A. M. & Hancock, W. O., Mar 2020, In: Molecular biology of the cell. 31, 8, p. 782-792 11 p.

Research output: Contribution to journalArticlepeer-review

Three Beads Are Better Than One

Howard, J. & Hancock, W. O., Jan 7 2020, In: Biophysical journal. 118, 1, p. 1-3 3 p.

Research output: Contribution to journalComment/debatepeer-review

What is the correct stoichiometry of Kv2.1:Kv6.4 heteromers?

Pisupati, A., Mickolajczyk, K. J., Hancock, W. O. & Jegla, T., Nov 24 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 47, p. 29288-29289 2 p.

Research output: Contribution to journalLetterpeer-review

Kinesin-2 from C. reinhardtii Is an Atypically Fast and Auto-inhibited Motor that Is Activated by Heterotrimerization for Intraflagellar Transport

Sonar, P., Youyen, W., Cleetus, A., Wisanpitayakorn, P., Mousavi, S. I., Stepp, W. L., Hancock, W. O., Tüzel, E. & Ökten, Z., Mar 23 2020, In: Current Biology. 30, 6, p. 1160-1166.e5

Research output: Contribution to journalArticlepeer-review

The Tail of Kinesin-14a in Giardia Is a Dual Regulator of Motility

Tseng, K. F., Mickolajczyk, K. J., Feng, G., Feng, Q., Kwok, E. S., Howe, J., Barbar, E. J., Dawson, S. C., Hancock, W. O. & Qiu, W., Sep 21 2020, In: Current Biology. 30, 18, p. 3664-3671.e4

Research output: Contribution to journalArticlepeer-review

A kinetic dissection of the fast and superprocessive kinesin-3 KIF1A reveals a predominant one-head-bound state during its chemomechanical cycle

Zaniewski, T. M., Gicking, A. M., Fricks, J. & Hancock, W. O., Dec 25 2020, In: Journal of Biological Chemistry. 295, 52, p. 17889-17903 15 p.

Research output: Contribution to journalArticlepeer-review

Motor Dynamics Underlying Cargo Transport by Pairs of Kinesin-1 and Kinesin-3 Motors

Arpağ, G., Norris, S. R., Mousavi, S. I., Soppina, V., Verhey, K. J., Hancock, W. O. & Tüzel, E., Mar 19 2019, In: Biophysical journal. 116, 6, p. 1115-1126 12 p.

Research output: Contribution to journalArticlepeer-review