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Recent Publications
Cargo adaptor identity controls the mechanism and kinetics of dynein activation[Figure presented]
Gillies, J. P., Little, S. R., Siva, A., Hancock, W. O. & DeSantis, M. E., Apr 2025, In: Journal of Biological Chemistry. 301, 4, 108358.Research output: Contribution to journal › Article › peer-review
Lignin impairs Cel7A degradation of in vitro lignified cellulose by impeding enzyme movement and not by acting as a sink
Haviland, Z. K., Nong, D., Zexer, N., Tien, M., Anderson, C. T. & Hancock, W. O., Dec 2024, In: Biotechnology for Biofuels and Bioproducts. 17, 1, 7.Research output: Contribution to journal › Article › peer-review
Single-molecule tracking reveals dual front door/back door inhibition of Cel7A cellulase by its product cellobiose
Nong, D., Haviland, Z. K., Zexer, N., Pfaff, S. A., Cosgrove, D. J., Tien, M., Anderson, C. T. & Hancock, W. O., Apr 30 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 18, e2322567121.Research output: Contribution to journal › Article › peer-review
Xylan inhibition of cellulase binding and processivity observed at single-molecule resolution
Zexer, N., Paradiso, A., Nong, D., Haviland, Z. K., Hancock, W. O. & Anderson, C. T., Mar 5 2024, In: RSC Sustainability. 2, 4, p. 1118-1127 10 p.Research output: Contribution to journal › Article › peer-review
Measuring PETase enzyme kinetics by single-molecule microscopy
Zhang, Y. & Hancock, W. O., Nov 5 2024, In: Biophysical journal. 123, 21, p. 3669-3677 9 p.Research output: Contribution to journal › Article › peer-review
Simulations suggest robust microtubule attachment of kinesin and dynein in antagonistic pairs
Ma, T. C., Gicking, A. M., Feng, Q. & Hancock, W. O., Aug 22 2023, In: Biophysical journal. 122, 16, p. 3299-3313 15 p.Research output: Contribution to journal › Article › peer-review
KIF1A is kinetically tuned to be a superengaging motor under hindering loads
Pyrpassopoulos, S., Gicking, A. M., Zaniewski, T. M., Hancock, W. O. & Ostap, E. M., Jan 10 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 2, e2216903120.Research output: Contribution to journal › Article › peer-review
Positive charge in the K-loop of the kinesin-3 motor KIF1A regulates superprocessivity by enhancing microtubule affinity in the one-head–bound state
Zaniewski, T. M. & Hancock, W. O., Feb 2023, In: Journal of Biological Chemistry. 299, 2, 102818.Research output: Contribution to journal › Article › peer-review
Measurements and simulations of microtubule growth imply strong longitudinal interactions and reveal a role for GDP on the elongating end
Cleary, J. M., Kim, T., Cook, A. S. I., McCormick, L. A., Hancock, W. O. & Rice, L. M., Apr 2022, In: eLife. 11, e75931.Research output: Contribution to journal › Article › peer-review
Kinesin-1,-2, and-3 motors use family-specific mechanochemical strategies to effectively compete with dynein during bidirectional transport
Gicking, A. M., Ma, T. C., Feng, Q., Jiang, R., Badieyan, S., Cianfrocco, M. A. & Hancock, W. O., Sep 2022, In: eLife. 11, e82228.Research output: Contribution to journal › Article › peer-review
Intracellular transport: KIF1C produces force along with a few slips
Hancock, W. O., Sep 12 2022, In: Current Biology. 32, 17, p. R914-R916Research output: Contribution to journal › Comment/debate › peer-review
Synergy between inhibitors of two mitotic spindle assembly motors undermines an adaptive response
Solon, A. L., Zaniewski, T. M., O’Brien, P., Clasby, M., Hancock, W. O. & Ohi, R., Dec 1 2022, In: Molecular biology of the cell. 33, 14, ar132.Research output: Contribution to journal › Article › peer-review
Measurement of the persistence length of cytoskeletal filaments using curvature distributions
Wisanpitayakorn, P., Mickolajczyk, K. J., Hancock, W. O., Vidali, L. & Tüzel, E., May 17 2022, In: Biophysical journal. 121, 10, p. 1813-1822 10 p.Research output: Contribution to journal › Article › peer-review
Molecular mechanisms underlying microtubule growth dynamics
Cleary, J. M. & Hancock, W. O., May 24 2021, In: Current Biology. 31, 10, p. R560-R573Research output: Contribution to journal › Review article › peer-review
Trim9 and Klp61F promote polymerization of new dendritic microtubules along parallel microtubules
Feng, C., Cleary, J. M., Kothe, G. O., Stone, M. C., Weiner, A. T., Hertzler, J. I., Hancock, W. O. & Rolls, M. M., Jun 2021, In: Journal of Cell Science. 134, 11, jcs258437.Research output: Contribution to journal › Article › peer-review