Research Summary
Stephen Schaeffer interested in the genomic processes that alter gene and chromosomal frequencies in natural populations of plants and animals. He tests hypotheses about how chromosomal inversions arise, spread, and are maintained in populations.
In the News
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Recent Publications
How chromosomal inversions reorient the evolutionary process
Berdan, E. L., Barton, N. H., Butlin, R., Charlesworth, B., Faria, R., Fragata, I., Gilbert, K. J., Jay, P., Kapun, M., Lotterhos, K. E., Mérot, C., Durmaz Mitchell, E., Pascual, M., Peichel, C. L., Rafajlović, M., Westram, A. M., Schaeffer, S. W., Johannesson, K. & Flatt, T., Dec 2023, In: Journal of Evolutionary Biology. 36, 12, p. 1761-1782 22 p.Research output: Contribution to journal › Review article › peer-review
The relevance of chromatin architecture to genome rearrangements in Drosophila
Wright, D. & Schaeffer, S. W., Aug 1 2022, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 377, 1856, 20210206.Research output: Contribution to journal › Article › peer-review
Drosophila Evolution over Space and Time (DEST): A New Population Genomics Resource
Kapun, M., Nunez, J. C. B., Bogaerts-Márquez, M., Murga-Moreno, J., Paris, M., Outten, J., Coronado-Zamora, M., Tern, C., Rota-Stabelli, O., García Guerreiro, M. P., Casillas, S., Orengo, D. J., Puerma, E., Kankare, M., Ometto, L., Loeschcke, V., Onder, B. S., Abbott, J. K., Schaeffer, S. W. & Rajpurohit, S. & 50 others, , 2021, In: Molecular biology and evolution. 38, 12, p. 5782-5805 24 p.Research output: Contribution to journal › Article › peer-review
Broad geographic sampling reveals the shared basis and environmental correlates of seasonal adaptation in drosophila
Machado, H. E., Bergland, A. O., Taylor, R., Tilk, S., Behrman, E., Dyer, K., Fabian, D. K., Flatt, T., González, J., Karasov, T. L., Kim, B., Kozeretska, I., Lazzaro, B. P., Merritt, T. J. S., Pool, J. E., O’brien, K., Rajpurohit, S., Roy, P. R., Schaeffer, S. W. & Serga, S. & 2 others, , Jun 2021, In: eLife. 10, e67577.Research output: Contribution to journal › Article › peer-review
Extensive recombination suppression and epistatic selection causes chromosome-wide differentiation of a selfish sex chromosome in drosophila pseudoobscura
Fuller, Z. L., Koury, S. A., Leonard, C. J., Young, R. E., Ikegami, K., Westlake, J., Richards, S., Schaeffer, S. W. & Phadnis, N., Sep 2020, In: Genetics. 216, 1, p. 205-226 22 p.Research output: Contribution to journal › Article › peer-review
How chromosomal rearrangements shape adaptation and speciation: Case studies in Drosophila pseudoobscura and its sibling species Drosophila persimilis
Fuller, Z. L., Koury, S. A., Phadnis, N. & Schaeffer, S. W., Mar 2019, In: Molecular ecology. 28, 6, p. 1283-1301 19 p.Research output: Contribution to journal › Article › peer-review
Ancestral polymorphisms explain the role of chromosomal inversions in speciation
Fuller, Z. L., Leonard, C. J., Young, R. E., Schaeffer, S. W. & Phadnis, N., Jul 2018, In: PLoS genetics. 14, 7, e1007526.Research output: Contribution to journal › Article › peer-review
Muller “elements” in Drosophila: How the search for the genetic basis for speciation led to the birth of comparative genomics
Schaeffer, S. W., Sep 2018, In: Genetics. 210, 1, p. 3-13 11 p.Research output: Contribution to journal › Article › peer-review
Genomics of natural populations: Evolutionary forces that establish and maintain gene arrangements in Drosophila pseudoobscura
Fuller, Z. L., Haynes, G. D., Richards, S. & Schaeffer, S. W., Dec 2017, In: Molecular ecology. 26, 23, p. 6539-6562 24 p.Research output: Contribution to journal › Article › peer-review
Evolution of Single-Domain Globins in Hydrothermal Vent Scale-Worms
Projecto-Garcia, J., Le Port, A. S., Govindji, T., Jollivet, D., Schaeffer, S. W. & Hourdez, S., Dec 1 2017, In: Journal Of Molecular Evolution. 85, 5-6, p. 172-187 16 p.Research output: Contribution to journal › Article › peer-review
Genomics of natural populations: How differentially expressed genes shape the evolution of chromosomal inversions in Drosophila pseudoobscura
Fuller, Z. L., Haynes, G. D., Richards, S. & Schaeffer, S. W., Sep 2016, In: Genetics. 204, 1, p. 287-301 15 p.Research output: Contribution to journal › Article › peer-review
Investigation of population structure in Gulf of Mexico Seepiophila jonesi (Polychaeta, Siboglinidae) using cross-amplified microsatellite loci
Huang, C., Schaeffer, S. W., Fisher, C. R. & Cowart, D. A., 2016, In: PeerJ. 2016, 8, e2366.Research output: Contribution to journal › Article › peer-review
Exemplar or matching: modeling DCJ problems with unequal content genome data
Yin, Z., Tang, J., Schaeffer, S. W. & Bader, D. A., Nov 1 2016, In: Journal of Combinatorial Optimization. 32, 4, p. 1165-1181 17 p.Research output: Contribution to journal › Article › peer-review
Species distribution and population connectivity of deep-sea mussels at hydrocarbon seeps in the Gulf of Mexico
Faure, B., Schaeffer, S. W. & Fisher, C. R., Apr 10 2015, In: PloS one. 10, 4, e0118460.Research output: Contribution to journal › Article › peer-review
Selective forces acting during multi-domain protein evolution: the case of multi-domain globins
Projecto-Garcia, J., Jollivet, D., Mary, J., Lallier, F. H., Schaeffer, S. W. & Hourdez, S., Dec 25 2015, In: SpringerPlus. 4, 1, 354.Research output: Contribution to journal › Article › peer-review