Shantu Amin

Profile Photo
Image
Email
IEE Research Themes
Affiliate Researcher
Titles and Affiliations
Professor, Department of Pharmacology

Research Summary

Mechanisms of chemical carcinogenesis as a tool for developing chemopreventive strategies to reduce the morbidity and mortality from cancer. In particular focusing on structure-activity studies with mutagenic and carcinogenic polycyclic aromatic hydrocarbons (PAHs).

Research Keywords

Recent Publications

Lipoxygenase catalyzed metabolites derived from docosahexaenoic acid are promising antitumor agents against breast cancer

Chen, K. M., Thompson, H., Vanden-Heuvel, J. P., Sun, Y. W., Trushin, N., Aliaga, C., Gowda, K., Amin, S., Stanley, B., Manni, A. & El-Bayoumy, K., Dec 2021, In: Scientific reports. 11, 1, 410.

Research output: Contribution to journalArticlepeer-review

The environmental pollutant and tobacco smoke constituent dibenzo[def,p]chrysene is a co-factor for malignant progression of mouse oral papillomavirus infections

Christensen, N. D., Chen, K. M., Hu, J., Stairs, D. B., Sun, Y. W., Aliaga, C., Balogh, K. K., Atkins, H., Shearer, D., Li, J., Brendle, S. A., Gowda, K., Amin, S., Walter, V., Viscidi, R. & El-Bayoumy, K., Jan 5 2021, In: Chemico-Biological Interactions. 333, 109321.

Research output: Contribution to journalArticlepeer-review

The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia

Annageldiyev, C., Gowda, K., Patel, T., Bhattacharya, P., Tan, S. F., Iyer, S., Desai, D., Dovat, S., Feith, D. J., Loughran, T. P., Amin, S., Claxton, D. & Sharma, A., Mar 1 2020, In: Haematologica. 105, 3, p. 687-696 10 p.

Research output: Contribution to journalArticlepeer-review

The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia

Annageldiyev, C., Tan, S. F., Thakur, S., Dhanyamraju, P. K., Ramisetti, S. R., Bhadauria, P., Schick, J., Zeng, Z., Sharma, V., Dunton, W., Dovat, S., Desai, D., Zheng, H., Feith, D. J., Loughran, T. P., Amin, S., Sharma, A. K., Claxton, D. & Sharma, A., Apr 1 2020, In: Frontiers in Oncology. 10, 393.

Research output: Contribution to journalArticlepeer-review

Black raspberry inhibits oral tumors in mice treated with the tobacco smoke constituent dibenzo(def,p)chrysene via genetic and epigenetic alterations

Chen, K. M., Sun, Y. W., Kawasawa, Y. I., Salzberg, A. C., Zhu, J., Gowda, K., Aliaga, C., Amin, S., Atkins, H. & El-Bayoumy, K., 2020, In: Cancer Prevention Research. 13, 4, p. 357-365 9 p.

Research output: Contribution to journalArticlepeer-review

Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents

Dinavahi, S. S., Gowda, R., Bazewicz, C. G., Battu, M. B., Lin, J. M., Chitren, R. J., Pandey, M. K., Amin, S., Robertson, G. P. & Gowda, K., Feb 1 2020, In: European Journal of Medicinal Chemistry. 187, 111962.

Research output: Contribution to journalArticlepeer-review

Development of a Novel Multi-Isoform ALDH Inhibitor Effective as an Antimelanoma Agent

Dinavahi, S. S., Gowda, R., Gowda, K., Bazewicz, C. G., Chirasani, V. R., Battu, M. B., Berg, A., Dokholyan, N. V., Amin, S. & Robertson, G. P., Feb 1 2020, In: Molecular cancer therapeutics. 19, 2, p. 447-459 13 p.

Research output: Contribution to journalArticlepeer-review

Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity

Dong, F., Hao, F., Murray, I. A., Smith, P. B., Koo, I., Tindall, A. M., Kris-Etherton, P. M., Gowda, K., Amin, S. G., Patterson, A. D. & Perdew, G. H., Nov 9 2020, In: Gut microbes. 12, 1, p. 1-24 24 p.

Research output: Contribution to journalArticlepeer-review

Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity

Muku, G. E., Kusnadi, A., Kuzu, G., Tanos, R., Murray, I. A., Gowda, K., Amin, S. & Perdew, G. H., Feb 1 2020, In: Laboratory Investigation. 100, 2, p. 250-264 15 p.

Research output: Contribution to journalArticlepeer-review

The Essential Role of Selenoproteins in the Resolution of Citrobacter rodentium-Induced Intestinal Inflammation

Nettleford, S. K., Zhao, L., Qian, F., Herold, M., Arner, B., Desai, D., Amin, S., Xiong, N., Singh, V., Carlson, B. A. & Prabhu, K. S., Jul 8 2020, In: Frontiers in Nutrition. 7, 96.

Research output: Contribution to journalArticlepeer-review