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IEE Research Themes
Affiliate Researcher
Titles and Affiliations
Professor, Department of Pharmacology
Research Summary
Mechanisms of chemical carcinogenesis as a tool for developing chemopreventive strategies to reduce the morbidity and mortality from cancer. In particular focusing on structure-activity studies with mutagenic and carcinogenic polycyclic aromatic hydrocarbons (PAHs).Research Keywords
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Recent Publications
Targeting Protein Translation in Melanoma by Inhibiting EEF-2 Kinase Regulates Cholesterol Metabolism though SREBP2 to Inhibit Tumour Development
Dinavahi, S. S., Chen, Y. C., Gowda, R., Dhanyamraju, P. K., Punnath, K., Desai, D., Berg, A., Kimball, S. R., Amin, S., Yang, J. M. & Robertson, G. P., Apr 1 2022, In: International journal of molecular sciences. 23, 7, 3481.Research output: Contribution to journal › Article › peer-review
Influence of ceramide on lipid domain stability studied with small-angle neutron scattering: The role of acyl chain length and unsaturation
DiPasquale, M., Deering, T. G., Desai, D., Sharma, A. K., Amin, S., Fox, T. E., Kester, M., Katsaras, J., Marquardt, D. & Heberle, F. A., Jul 2022, In: Chemistry and Physics of Lipids. 245, 105205.Research output: Contribution to journal › Article › peer-review
Selenium-Based Novel Epigenetic Regulators Offer Effective Chemotherapeutic Alternative with Wider Safety Margins in Experimental Colorectal Cancer
Ghanghas, P., Sharma, M., Desai, D., Raza, K., Bhalla, A., Kumar, P., Narula, D., Amin, S., Sanyal, S. N. & Kaushal, N., Feb 2022, In: Biological Trace Element Research. 200, 2, p. 635-646 12 p.Research output: Contribution to journal › Article › peer-review
Recent Advances in the Chemistry and Therapeutic Evaluation of Naturally Occurring and Synthetic Withanolides
Singh, A., Raza, A., Amin, S., Damodaran, C. & Sharma, A. K., Feb 1 2022, In: Molecules. 27, 3, 886.Research output: Contribution to journal › Review article › peer-review
Activating Sphingosine-1-phospahte signaling in endothelial cells increases myosin light chain phosphorylation to decrease endothelial permeability thereby inhibiting cancer metastasis
Chen, Y. C., Dinavahi, S. S., Feng, Q., Gowda, R., Ramisetti, S., Xia, X., LaPenna, K. B., Chirasani, V. R., Cho, S. H., Hafenstein, S. L., Battu, M. B., Berg, A., Sharma, A. K., Kirchhausen, T., Dokholyan, N. V., Amin, S., He, P. & Robertson, G. P., May 28 2021, In: Cancer Letters. 506, p. 107-119 13 p.Research output: Contribution to journal › Article › peer-review
Lipoxygenase catalyzed metabolites derived from docosahexaenoic acid are promising antitumor agents against breast cancer
Chen, K. M., Thompson, H., Vanden-Heuvel, J. P., Sun, Y. W., Trushin, N., Aliaga, C., Gowda, K., Amin, S., Stanley, B., Manni, A. & El-Bayoumy, K., Dec 2021, In: Scientific reports. 11, 1, 410.Research output: Contribution to journal › Article › peer-review
The environmental pollutant and tobacco smoke constituent dibenzo[def,p]chrysene is a co-factor for malignant progression of mouse oral papillomavirus infections
Christensen, N. D., Chen, K. M., Hu, J., Stairs, D. B., Sun, Y. W., Aliaga, C., Balogh, K. K., Atkins, H., Shearer, D., Li, J., Brendle, S. A., Gowda, K., Amin, S., Walter, V., Viscidi, R. & El-Bayoumy, K., Jan 5 2021, In: Chemico-Biological Interactions. 333, 109321.Research output: Contribution to journal › Article › peer-review
Diminished Hepatocarcinogenesis by a Potent, High-Affinity Human PPARα Agonist in PPARA-Humanized Mice
Foreman, J. E., Koga, T., Kosyk, O., Kang, B. H., Zhu, X., Cohen, S. M., Billy, L. J., Sharma, A. K., Amin, S., Gonzalez, F. J., Rusyn, I. & Peters, J. M., Sep 1 2021, In: Toxicological Sciences. 183, 1, p. 70-80 11 p.Research output: Contribution to journal › Article › peer-review
Species Differences between Mouse and Human PPARα in Modulating the Hepatocarcinogenic Effects of Perinatal Exposure to a High-Affinity Human PPARα Agonist in Mice
Foreman, J. E., Koga, T., Kosyk, O., Kang, B. H., Zhu, X., Cohen, S. M., Billy, L. J., Sharma, A. K., Amin, S., Gonzalez, F. J., Rusyn, I. & Peters, J. M., Sep 1 2021, In: Toxicological Sciences. 183, 1, p. 81-92 12 p.Research output: Contribution to journal › Article › peer-review
Dj4 targets the rho-associated protein kinase pathway and attenuates disease progression in preclinical murine models of acute myeloid leukemia
Golla, U., Ehudin, M. A., Annageldiyev, C., Zeng, Z., Bastihalli Tukaramrao, D., Tarren, A., Date, A. A., Elcheva, I., Berg, A., Amin, S., Loughran, T. P., Kester, M., Desai, D., Dovat, S., Claxton, D. & Sharma, A., Oct 1 2021, In: Cancers. 13, 19, 4889.Research output: Contribution to journal › Article › peer-review
Novel seleno-aspirinyl compound as-10 induces apoptosis, g1 arrest of pancreatic ductal adenocarcinoma cells, inhibits their nf-κb signaling, and synergizes with gemcitabine cytotoxicity
Karelia, D. N., Kim, S., Pandey, M. K., Plano, D., Amin, S., Lu, J. & Sharma, A. K., May 1 2021, In: International journal of molecular sciences. 22, 9, 4966.Research output: Contribution to journal › Article › peer-review
Chromatin remodeling by the histone methyltransferase EZH2 drives lung pre-malignancy and is a target for cancer prevention
Tellez, C. S., Picchi, M. A., Juri, D., Do, K., Desai, D. H., Amin, S. G., Hutt, J. A., Filipczak, P. T. & Belinsky, S. A., Dec 2021, In: Clinical Epigenetics. 13, 1, 44.Research output: Contribution to journal › Article › peer-review
D1 dopamine receptors intrinsic activity and functional selectivity affect working memory in prefrontal cortex
Yang, Y., Lee, S. M., Imamura, F., Gowda, K., Amin, S. & Mailman, R. B., Feb 2021, In: Molecular Psychiatry. 26, 2, p. 645-655 11 p.Research output: Contribution to journal › Article › peer-review
The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia
Annageldiyev, C., Gowda, K., Patel, T., Bhattacharya, P., Tan, S. F., Iyer, S., Desai, D., Dovat, S., Feith, D. J., Loughran, T. P., Amin, S., Claxton, D. & Sharma, A., Mar 1 2020, In: Haematologica. 105, 3, p. 687-696 10 p.Research output: Contribution to journal › Article › peer-review
The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia
Annageldiyev, C., Tan, S. F., Thakur, S., Dhanyamraju, P. K., Ramisetti, S. R., Bhadauria, P., Schick, J., Zeng, Z., Sharma, V., Dunton, W., Dovat, S., Desai, D., Zheng, H., Feith, D. J., Loughran, T. P., Amin, S., Sharma, A. K., Claxton, D. & Sharma, A., Apr 1 2020, In: Frontiers in Oncology. 10, 393.Research output: Contribution to journal › Article › peer-review