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Titles and Affiliations
Professor, Department of Pharmacology
Research Summary
Mechanisms of chemical carcinogenesis as a tool for developing chemopreventive strategies to reduce the morbidity and mortality from cancer. In particular focusing on structure-activity studies with mutagenic and carcinogenic polycyclic aromatic hydrocarbons (PAHs).In the News
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Recent Publications
Pharmacological agents targeting drug-tolerant persister cells in cancer
Chen, Y. C., Gowda, K., Amin, S., Schell, T. D., Sharma, A. K. & Robertson, G. P., May 2024, In: Pharmacological Research. 203, 107163.Research output: Contribution to journal › Review article › peer-review
Bile salt hydrolase catalyses formation of amine-conjugated bile acids
Rimal, B., Collins, S. L., Tanes, C. E., Rocha, E. R., Granda, M. A., Solanki, S., Hoque, N. J., Gentry, E. C., Koo, I., Reilly, E. R., Hao, F., Paudel, D., Singh, V., Yan, T., Kim, M. S., Bittinger, K., Zackular, J. P., Krausz, K. W., Desai, D., Amin, S., & 10 others, Feb 22 2024, In: Nature. 626, 8000, p. 859-863 5 p.Research output: Contribution to journal › Article › peer-review
Gender Difference in DNA Damage Induced by the Environmental Carcinogen Dibenzo[def,p]chrysene Individually and in Combination with Mouse Papillomavirus Infection in the Mouse Oral Cavity
Chen, K-M., Sun, Y-W., Hu, J., Balogh, K., Gowda, K., Aliaga, C., Sun, D., Christensen, N., Amin, S. & El-Bayoumy, K., 2023, (Accepted/In press) In: ACS Omega.Research output: Contribution to journal › Article › peer-review
Complex chemical signals dictate Ah receptor activation through the gut-lung axis
Dong, F., Murray, I. A., Annalora, A., Coslo, D. M., Desai, D., Gowda, K., Yang, J., Wang, D., Koo, I., Hao, F., Amin, S. G., Patterson, A. D., Marcus, C. & Perdew, G. H., Jul 1 2023, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37, 7, p. e23010Research output: Contribution to journal › Article › peer-review
Characterization of Anticancer Effects of the Analogs of DJ4, a Novel Selective Inhibitor of ROCK and MRCK Kinases
Kale, V. P., Hengst, J. A., Sharma, A. K., Golla, U., Dovat, S., Amin, S. G., Yun, J. K. & Desai, D. H., Aug 2023, In: Pharmaceuticals. 16, 8, 1060.Research output: Contribution to journal › Article › peer-review
Selenocoxib-3, a novel anti-inflammatory therapeutic effectively resolves colitis
Kaur, R., Desai, D., Amin, S., Raza, K., Bhalla, A., Yadav, P. & Kaushal, N., Mar 2023, In: Molecular and Cellular Biochemistry. 478, 3, p. 621-636 16 p.Research output: Contribution to journal › Article › peer-review
Contribution of Circulating Host and Microbial Tryptophan Metabolites Toward Ah Receptor Activation
Morgan, E. W., Dong, F., Annalora, A. J., Murray, I. A., Wolfe, T., Erickson, R., Gowda, K., Amin, S. G., Petersen, K. S., Kris-Etherton, P. M., Marcus, C. B., Walk, S. T., Patterson, A. D. & Perdew, G. H., Jan 1 2023, In: International Journal of Tryptophan Research. 16Research output: Contribution to journal › Article › peer-review
Induction of AHR Signaling in Response to the Indolimine Class of Microbial Stress Metabolites
Patel, D., Murray, I. A., Dong, F., Annalora, A. J., Gowda, K., Coslo, D. M., Krzeminski, J., Koo, I., Hao, F., Amin, S. G., Marcus, C. B., Patterson, A. D. & Perdew, G. H., Sep 2023, In: Metabolites. 13, 9, 985.Research output: Contribution to journal › Article › peer-review
Lead optimization of aryl hydrocarbon receptor ligands for treatment of inflammatory skin disorders
Rikken, G., Smith, K. J., van den Brink, N. J. M., Smits, J. P. H., Gowda, K., Alnemri, A., Kuzu, G. E., Murray, I. A., Lin, J. M., Smits, J. G. A., van Vlijmen-Willems, I. M., Amin, S. G., Perdew, G. H. & van den Bogaard, E. H., Feb 2023, In: Biochemical Pharmacology. 208, 115400.Research output: Contribution to journal › Article › peer-review
Aryl Hydrocarbon Receptor Activation Coordinates Mouse Small Intestinal Epithelial Cell Programming
Zhou, X., Chakraborty, D., Murray, I. A., Coslo, D., Kehs, Z., Vijay, A., Ton, C., Desai, D., Amin, S. G., Patterson, A. D. & Perdew, G. H., Feb 2023, In: Laboratory Investigation. 103, 2, 100012.Research output: Contribution to journal › Article › peer-review
Accumulation of Linoleic Acid by Altered Peroxisome Proliferator-Activated Receptor-α Signaling Is Associated with Age-Dependent Hepatocarcinogenesis in Ppara Transgenic Mice
Zhu, X., Liu, Q., Patterson, A. D., Sharma, A. K., Amin, S. G., Cohen, S. M., Gonzalez, F. J. & Peters, J. M., Aug 2023, In: Metabolites. 13, 8, 936.Research output: Contribution to journal › Article › peer-review
Delivery of Therapeutic miR-148b Mimic via Poly(β Amino Ester) Polyplexes for Post-transcriptional Gene Regulation and Apoptosis of A549 Cells
Alden, N. A., Arrizabalaga, J. H., Liu, Y., Amin, S., Gowda, K., Yao, S., Archetti, M., Glick, A. B. & Hayes, D. J., Aug 16 2022, In: Langmuir. 38, 32, p. 9833-9843 11 p.Research output: Contribution to journal › Article › peer-review
Black Raspberry Extract Enhances Glutathione Conjugation of the Fjord-Region Diol Epoxide Derived from the Tobacco Carcinogen Dibenzo[ def, p]chrysene in Human Oral Cells
Chen, K. M., Sun, Y. W., Sun, D., Gowda, K., Amin, S. & El-Bayoumy, K., Nov 21 2022, In: Chemical research in toxicology. 35, 11, p. 2152-2159 8 p.Research output: Contribution to journal › Article › peer-review
Detection of DNA adducts derived from the tobacco carcinogens, benzo[a]pyrene and dibenzo[def,p]chrysene in human oral buccal cells
Chen, K. M., Sun, Y. W., Krebs, N. M., Sun, D., Krzeminski, J., Reinhart, L., Gowda, K., Amin, S., Mallery, S., Richie, J. P. & El-Bayoumy, K., Aug 1 2022, In: Carcinogenesis. 43, 8, p. 746-753 8 p.Research output: Contribution to journal › Article › peer-review
Drug-Tolerant Persister Cells in Cancer Therapy Resistance
Dhanyamraju, P. K., Schell, T. D., Amin, S. & Robertson, G. P., Jul 15 2022, In: Cancer Research. 82, 14, p. 2503-2514 12 p.Research output: Contribution to journal › Review article › peer-review