Shantu Amin

Affiliate Researcher
Titles and Affiliations
Professor, Department of Pharmacology

Research Summary

Mechanisms of chemical carcinogenesis as a tool for developing chemopreventive strategies to reduce the morbidity and mortality from cancer. In particular focusing on structure-activity studies with mutagenic and carcinogenic polycyclic aromatic hydrocarbons (PAHs).

Research Keywords

Recent Publications

Delivery of Therapeutic miR-148b Mimic via Poly(β Amino Ester) Polyplexes for Post-transcriptional Gene Regulation and Apoptosis of A549 Cells

Alden, N. A., Arrizabalaga, J. H., Liu, Y., Amin, S., Gowda, K., Yao, S., Archetti, M., Glick, A. B. & Hayes, D. J., Aug 16 2022, In: Langmuir. 38, 32, p. 9833-9843 11 p.

Research output: Contribution to journalArticlepeer-review

Black Raspberry Extract Enhances Glutathione Conjugation of the Fjord-Region Diol Epoxide Derived from the Tobacco Carcinogen Dibenzo[ def, p]chrysene in Human Oral Cells

Chen, K. M., Sun, Y. W., Sun, D., Gowda, K., Amin, S. & El-Bayoumy, K., Nov 21 2022, In: Chemical research in toxicology. 35, 11, p. 2152-2159 8 p.

Research output: Contribution to journalArticlepeer-review

Detection of DNA adducts derived from the tobacco carcinogens, benzo[a]pyrene and dibenzo[def,p]chrysene in human oral buccal cells

Chen, K. M., Sun, Y. W., Krebs, N. M., Sun, D., Krzeminski, J., Reinhart, L., Gowda, K., Amin, S., Mallery, S., Richie, J. P. & El-Bayoumy, K., Sep 19 2022, In: Carcinogenesis. 43, 8, p. 746-753 8 p.

Research output: Contribution to journalArticlepeer-review

Drug-Tolerant Persister Cells in Cancer Therapy Resistance

Dhanyamraju, P. K., Schell, T. D., Amin, S. & Robertson, G. P., Jul 15 2022, In: Cancer Research. 82, 14, p. 2503-2514 12 p.

Research output: Contribution to journalReview articlepeer-review

Targeting Protein Translation in Melanoma by Inhibiting EEF-2 Kinase Regulates Cholesterol Metabolism though SREBP2 to Inhibit Tumour Development

Dinavahi, S. S., Chen, Y. C., Gowda, R., Dhanyamraju, P. K., Punnath, K., Desai, D., Berg, A., Kimball, S. R., Amin, S., Yang, J. M. & Robertson, G. P., Apr 1 2022, In: International journal of molecular sciences. 23, 7, 3481.

Research output: Contribution to journalArticlepeer-review

Influence of ceramide on lipid domain stability studied with small-angle neutron scattering: The role of acyl chain length and unsaturation

DiPasquale, M., Deering, T. G., Desai, D., Sharma, A. K., Amin, S., Fox, T. E., Kester, M., Katsaras, J., Marquardt, D. & Heberle, F. A., Jul 2022, In: Chemistry and Physics of Lipids. 245, 105205.

Research output: Contribution to journalArticlepeer-review

Development of a novel Bruton’s tyrosine kinase inhibitor that exerts anti-cancer activities potentiates response of chemotherapeutic agents in multiple myeloma stem cell-like cells

Elbezanti, W. O., Al-Odat, O. S., Chitren, R., Singh, J. K., Srivastava, S. K., Gowda, K., Amin, S., Robertson, G. P., Nemmara, V. V., Jonnalagadda, S. C., Budak-Alpdogan, T. & Pandey, M. K., Sep 9 2022, In: Frontiers in Pharmacology. 13, 894535.

Research output: Contribution to journalArticlepeer-review

Selenium-Based Novel Epigenetic Regulators Offer Effective Chemotherapeutic Alternative with Wider Safety Margins in Experimental Colorectal Cancer

Ghanghas, P., Sharma, M., Desai, D., Raza, K., Bhalla, A., Kumar, P., Narula, D., Amin, S., Sanyal, S. N. & Kaushal, N., Feb 2022, In: Biological Trace Element Research. 200, 2, p. 635-646 12 p.

Research output: Contribution to journalArticlepeer-review

Glycine-β-muricholic acid antagonizes the intestinal farnesoid X receptor–ceramide axis and ameliorates NASH in mice

Jiang, J., Ma, Y., Liu, Y., Lu, D., Gao, X., Krausz, K. W., Desai, D., Amin, S. G., Patterson, A. D., Gonzalez, F. J. & Xie, C., Dec 2022, In: Hepatology Communications. 6, 12, p. 3363-3378 16 p.

Research output: Contribution to journalArticlepeer-review

Selenocoxib-3, a novel anti-inflammatory therapeutic effectively resolves colitis

Kaur, R., Desai, D., Amin, S., Raza, K., Bhalla, A., Yadav, P. & Kaushal, N., 2022, (Accepted/In press) In: Molecular and Cellular Biochemistry.

Research output: Contribution to journalArticlepeer-review

Efficient Synthesis for Altering Side Chain Length on Cannabinoid Molecules and Their Effects in Chemotherapy and Chemotherapeutic Induced Neuropathic Pain

Raup-Konsavage, W. M., Sepulveda, D. E., Morris, D. P., Amin, S., Vrana, K. E., Graziane, N. M. & Desai, D., Dec 2022, In: Biomolecules. 12, 12, 1869.

Research output: Contribution to journalArticlepeer-review

Identification and biotin receptor-mediated activity of a novel seleno-biotin compound that inhibits viability of and induces apoptosis in ovarian cancer cells

Raza, A., Singh, A., Amin, S., Spallholz, J. E. & Sharma, A. K., Sep 25 2022, In: Chemico-Biological Interactions. 365, 110071.

Research output: Contribution to journalArticlepeer-review

Recent Advances in the Chemistry and Therapeutic Evaluation of Naturally Occurring and Synthetic Withanolides

Singh, A., Raza, A., Amin, S., Damodaran, C. & Sharma, A. K., Feb 1 2022, In: Molecules. 27, 3, 886.

Research output: Contribution to journalReview articlepeer-review

Activating Sphingosine-1-phospahte signaling in endothelial cells increases myosin light chain phosphorylation to decrease endothelial permeability thereby inhibiting cancer metastasis

Chen, Y. C., Dinavahi, S. S., Feng, Q., Gowda, R., Ramisetti, S., Xia, X., LaPenna, K. B., Chirasani, V. R., Cho, S. H., Hafenstein, S. L., Battu, M. B., Berg, A., Sharma, A. K., Kirchhausen, T., Dokholyan, N. V., Amin, S., He, P. & Robertson, G. P., May 28 2021, In: Cancer Letters. 506, p. 107-119 13 p.

Research output: Contribution to journalArticlepeer-review

Lipoxygenase catalyzed metabolites derived from docosahexaenoic acid are promising antitumor agents against breast cancer

Chen, K. M., Thompson, H., Vanden-Heuvel, J. P., Sun, Y. W., Trushin, N., Aliaga, C., Gowda, K., Amin, S., Stanley, B., Manni, A. & El-Bayoumy, K., Dec 2021, In: Scientific reports. 11, 1, 410.

Research output: Contribution to journalArticlepeer-review