Research Summary
Vector arthropods and the pathogens they transmit, with emphasis on release of genetically-modified mosquitoes for disease control, pathogen transmission dynamics and bioterrorism issues. Specifically, he studies how natural genetic variation in wild vector populations conditions phenotypic variation in pathogen transmission and how natural genetic variation in wild vector populations can be artificially altered to have a directed effect on pathogen transmission dynamics.
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Research Keywords
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Recent Publications
Multiple blood feeding bouts in mosquitoes allow for prolonged survival and are predicted to increase viral transmission during dry periods
Holmes, C. J., Chakraborty, S., Ajayi, O. M., Uhran, M. R., Frigard, R., Stacey, C. L., Susanto, E. E., Chen, S. C., Rasgon, J. L., DeGennaro, M., Xiao, Y. & Benoit, J. B., Feb 21 2025, In: iScience. 28, 2, 111760.Research output: Contribution to journal › Article › peer-review
The intensity of the transcriptional response varies across infection with distinct viral strains in an insect host
Ray, A. M., Tehel, A., Rasgon, J. L., Paxton, R. J. & Grozinger, C. M., Dec 2025, In: BMC genomics. 26, 1, 175.Research output: Contribution to journal › Article › peer-review
An Overview of Zika Virus and Zika Virus Induced Neuropathies
Wahaab, A., Mustafa, B. E., Hameed, M., Batool, H., Tran Nguyen Minh, H., Tawaab, A., Shoaib, A., Wei, J. & Rasgon, J. L., Jan 2025, In: International journal of molecular sciences. 26, 1, 47.Research output: Contribution to journal › Review article › peer-review
Variable effects of transient Wolbachia infections on alphaviruses in Aedes aegypti
Dodson, B. L., Pujhari, S., Brustolin, M., Metz, H. C. & Rasgon, J. L., Nov 2024, In: PLoS neglected tropical diseases. 2024-November, e0012633.Research output: Contribution to journal › Article › peer-review
Eilat virus (EILV) causes superinfection exclusion against West Nile virus (WNV) in a strain-specific manner in Culex tarsalis mosquitoes
Joseph, R. E., Bozic, J., Werling, K. L., Krizek, R. S., Urakova, N. & Rasgon, J. L., 2024, In: Journal of General Virology. 105, 8Research output: Contribution to journal › Article › peer-review
Gene Editing in the Chagas Disease Vector Rhodnius prolixus by Cas9-Mediated ReMOT Control
Lima, L., Berni, M., Mota, J., Bressan, D., Julio, A., Cavalcante, R., Macias, V., Li, Z., Rasgon, J. L., Bier, E. & Araujo, H., Apr 1 2024, In: CRISPR Journal. 7, 2, p. 88-99 12 p.Research output: Contribution to journal › Article › peer-review
Corrigendum: A mosquito small RNA genomics resource reveals dynamic evolution and host responses to viruses and transposons
Ma, Q., Srivastav, S. P., Gamez, S., Dayama, G., Feitosa-Suntheimer, F., Patterson, E. I., Johnson, R. M., Matson, E. M., Gold, A. S., Brackney, D. E., Connor, J. H., Colpitts, T. M., Hughes, G. L., Rasgon, J. L., Nolan, T., Akbari, O. S. & Lau, N. C., Feb 7 2024, In: Genome research. 34, 1, p. 160 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Precision-guided tools for malaria control
Rasgon, J. L., Aug 6 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 32, e2411587121.Research output: Contribution to journal › Comment/debate › peer-review
Microbiomes of Two Pest Fly Species of Pennsylvania Mushroom Houses
Sakamoto, J. M., Shikano, I. & Rasgon, J. L., Jul 2024, In: Insects. 15, 7, 525.Research output: Contribution to journal › Article › peer-review
Temperature affects viral kinetics and vectorial capacity of Aedes aegypti mosquitoes co-infected with Mayaro and Dengue viruses
Terradas, G., Manzano-Alvarez, J., Vanalli, C., Werling, K., Cattadori, I. M. & Rasgon, J. L., Dec 2024, In: Parasites and Vectors. 17, 1, 73.Research output: Contribution to journal › Article › peer-review
Alpha-mannosidase-2 modulates arbovirus infection in a pathogen- and Wolbachia-specific manner in Aedes aegypti mosquitoes
Urakova, N., Joseph, R. E., Huntsinger, A., Macias, V. M., Jones, M. J., Sigle, L. T., Li, M., Akbari, O. S., Xi, Z., Lymperopoulos, K., Sayre, R. T., McGraw, E. A. & Rasgon, J. L., Aug 2024, In: Insect Molecular Biology. 33, 4, p. 362-371 10 p.Research output: Contribution to journal › Article › peer-review
NS2B-D55E and NS2B-E65D Variations Are Responsible for Differences in NS2B-NS3 Protease Activities Between Japanese Encephalitis Virus Genotype I and III in Fluorogenic Peptide Model
Wahaab, A., Zhang, Y., Liu, K., Rasgon, J. L., Kang, L., Hameed, M., Li, C., Anwar, M. N., Zhang, Y., Shoaib, A., Li, B., Qiu, Y., Wei, J. & Ma, Z., Dec 2024, In: International journal of molecular sciences. 25, 23, 12680.Research output: Contribution to journal › Article › peer-review
Identification of MicroRNAs in the West Nile Virus Vector Culex tarsalis (Diptera: Culicidae)
Asad, S., Mehdi, A. M., Pujhari, S., Rückert, C., Ebel, G. D. & Rasgon, J. L., Mar 1 2023, In: Journal of medical entomology. 60, 2, p. 282-293 12 p.Research output: Contribution to journal › Article › peer-review
In Vitro and In Vivo Coinfection and Superinfection Dynamics of Mayaro and Zika Viruses in Mosquito and Vertebrate Backgrounds
Brustolin, M., Pujhari, S., Terradas, G., Werling, K., Asad, S., Metz, H. C., Henderson, C. A., Kim, D. & Rasgon, J. L., Jan 2023, In: Journal of virology. 97, 1Research output: Contribution to journal › Article › peer-review
Novel genome sequences and evolutionary dynamics of the North American anopheline species Anopheles freeborni, Anopheles crucians, Anopheles quadrimaculatus, and Anopheles albimanus
Henderson, C., Kemirembe, K., McKeand, S., Bergey, C. & Rasgon, J. L., Jan 2023, In: G3: Genes, Genomes, Genetics. 13, 1, jkac284.Research output: Contribution to journal › Article › peer-review