Gary Perdew

Seed Grant Committee Lead, Institute of Energy and the Environment
Titles and Affiliations
John T. And Paige S. Smith Professor, Veterinary and Biomedical Sciences

Research Summary

Research focuses on molecular mechanism(s) of toxicity, dioxin-mediated signal transduction, regulation of cellular homeostasis by the Ah receptor, Ah receptor-mediated control of gene expression and biochemistry of heat shock protein complexes. Research is interested in the long-term health effects of persistent exposure to industrial pollutants.

In the News

Research Keywords

Recent Publications

The Janus-facedness of the aryl hydrocarbon receptor pathway Report of the 6th International AHR Meeting: Research, Prevention, Therapy

Haarmann-Stemmann, T., Reichert, D., Coumoul, X., Lawrence, B. P., Perdew, G. H., Sherr, D. H., Weighardt, H., Rolfes, K. M. & Esser, C., Apr 2025, In: Biochemical Pharmacology. 234, 116808.

Research output: Contribution to journalReview articlepeer-review

Modulation of Ceramide-Induced Apoptosis in Enteric Neurons by Aryl Hydrocarbon Receptor Signaling: Unveiling a New Pathway beyond ER Stress

Anitha, M., Kumar, S. M., Koo, I., Perdew, G. H., Srinivasan, S. & Patterson, A. D., Aug 2024, In: International journal of molecular sciences. 25, 16, 8581.

Research output: Contribution to journalArticlepeer-review

Immune cell-intrinsic Ah receptor facilitates the expression of antimicrobial REG3G in the small intestine

Chakraborty, D., Coslo, D. M., Murray, I. A., Vijay, A., Patterson, A. D. & Perdew, G. H., Feb 29 2024, In: FASEB Journal. 38, 4, e23471.

Research output: Contribution to journalArticlepeer-review

Species differences in specific ligand-binding affinity and activation of AHR: The biological basis for calculation of relative effective potencies and toxic equivalence factors

Eaton, D. L., Simon, T. W., Kaminski, N. E., Perdew, G. H. & Nebert, D. W., May 2024, In: Regulatory Toxicology and Pharmacology. 149, 105598.

Research output: Contribution to journalReview articlepeer-review

The 2022 revised WHO TEFs for dioxins and dioxin-like chemicals: The importance of considering the use of species-specific information to determine relative effective potency for human-based risk assessment

Eaton, D. L., Simon, T. W., Kaminski, N. E., Perdew, G. H. & Nebert, D. W., May 2024, In: Regulatory Toxicology and Pharmacology. 149, 105599.

Research output: Contribution to journalComment/debatepeer-review

Effects of Early Life Exposures to the Aryl Hydrocarbon Receptor Ligand TCDF on Gut Microbiota and Host Metabolic Homeostasis in C57BL/6J Mice

Tian, Y., Rimal, B., Bisanz, J. E., Gui, W., Wolfe, T. M., Koo, I., Murray, I. A., Nettleford, S. K., Yokoyama, S., Dong, F., Koshkin, S., Prabhu, K. S., Turnbaugh, P. J., Walk, S. T., Perdew, G. H. & Patterson, A. D., Aug 2024, In: Environmental health perspectives. 132, 8, 087005.

Research output: Contribution to journalArticlepeer-review

Sphingosine Kinase 2 Regulates Aryl Hydrocarbon Receptor Nuclear Translocation and Target Gene Activation

Yokoyama, S., Koo, I., Aibara, D., Tian, Y., Murray, I. A., Collins, S. L., Coslo, D. M., Kono, M., Peters, J. M., Proia, R. L., Gonzalez, F. J., Perdew, G. H. & Patterson, A. D., Oct 28 2024, In: Advanced Science. 11, 40, 2400794.

Research output: Contribution to journalArticlepeer-review

Activation of Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) in Keratinocytes by Endogenous Fatty Acids

Zhu, B., Zhu, X., Borland, M. G., Ralph, D. H., Chiaro, C. R., Krausz, K. W., Ntambi, J. M., Glick, A. B., Patterson, A. D., Perdew, G. H., Gonzalez, F. J. & Peters, J. M., Jun 2024, In: Biomolecules. 14, 6, 606.

Research output: Contribution to journalArticlepeer-review

Molecular networking identifies an AHR-modulating benzothiazole from white button mushrooms (Agaricus bisporus)

Chen, X., Patterson, A. D., Perdew, G. H., Murray, I. A. & Kellogg, J. J., Jul 2023, In: Journal of Functional Foods. 106, 105602.

Research output: Contribution to journalArticlepeer-review

Complex chemical signals dictate Ah receptor activation through the gut-lung axis

Dong, F., Murray, I. A., Annalora, A., Coslo, D. M., Desai, D., Gowda, K., Yang, J., Wang, D., Koo, I., Hao, F., Amin, S. G., Patterson, A. D., Marcus, C. & Perdew, G. H., Jul 1 2023, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37, 7, p. e23010

Research output: Contribution to journalArticlepeer-review

Endogenous Tryptophan-Derived Ah Receptor Ligands are Dissociated from CYP1A1/1B1-Dependent Negative-Feedback

Dong, F., Annalora, A. J., Murray, I. A., Tian, Y., Marcus, C. B., Patterson, A. D. & Perdew, G. H., Jan 1 2023, In: International Journal of Tryptophan Research. 16

Research output: Contribution to journalArticlepeer-review

Alpha-tocopherylquinone differentially modulates claudins to enhance intestinal epithelial tight junction barrier via AhR and Nrf2 pathways

Ganapathy, A. S., Saha, K., Wang, A., Arumugam, P., Dharmaprakash, V., Yochum, G., Koltun, W., Nighot, M., Perdew, G., Thompson, T. A., Ma, T. & Nighot, P., Jul 25 2023, In: Cell Reports. 42, 7, 112705.

Research output: Contribution to journalArticlepeer-review

Third generation quinoline-3-carboxamide transcriptional disrupter of HDAC4, HIF-1α, and MEF-2 signaling for metastatic castration-resistant prostate cancer

Isaacs, J. T., Dalrymple, S. L., Antony, L., Marc Rosen, D., Coleman, I. M., Nelson, P. S., Kostova, M., Murray, I. A., Perdew, G. H., Denmeade, S. R., Akinboye, E. S. & Brennen, W. N., Nov 2023, In: Prostate. 83, 15, p. 1470-1493 24 p.

Research output: Contribution to journalArticlepeer-review

Contribution of Circulating Host and Microbial Tryptophan Metabolites Toward Ah Receptor Activation

Morgan, E. W., Dong, F., Annalora, A. J., Murray, I. A., Wolfe, T., Erickson, R., Gowda, K., Amin, S. G., Petersen, K. S., Kris-Etherton, P. M., Marcus, C. B., Walk, S. T., Patterson, A. D. & Perdew, G. H., Jan 1 2023, In: International Journal of Tryptophan Research. 16

Research output: Contribution to journalArticlepeer-review

Induction of AHR Signaling in Response to the Indolimine Class of Microbial Stress Metabolites

Patel, D., Murray, I. A., Dong, F., Annalora, A. J., Gowda, K., Coslo, D. M., Krzeminski, J., Koo, I., Hao, F., Amin, S. G., Marcus, C. B., Patterson, A. D. & Perdew, G. H., Sep 2023, In: Metabolites. 13, 9, 985.

Research output: Contribution to journalArticlepeer-review