Gary Perdew

Seed Grant Committee Lead, Institute of Energy and the Environment
Titles and Affiliations
John T. And Paige S. Smith Professor, Veterinary and Biomedical Sciences

Research Summary

Research focuses on molecular mechanism(s) of toxicity, dioxin-mediated signal transduction, regulation of cellular homeostasis by the Ah receptor, Ah receptor-mediated control of gene expression and biochemistry of heat shock protein complexes. Research is interested in the long-term health effects of persistent exposure to industrial pollutants.

In the News

Research Keywords

Recent Publications

Molecular networking identifies an AHR-modulating benzothiazole from white button mushrooms (Agaricus bisporus)

Chen, X., Patterson, A. D., Perdew, G. H., Murray, I. A. & Kellogg, J. J., Jul 2023, In: Journal of Functional Foods. 106, 105602.

Research output: Contribution to journalArticlepeer-review

Complex chemical signals dictate Ah receptor activation through the gut-lung axis

Dong, F., Murray, I. A., Annalora, A., Coslo, D. M., Desai, D., Gowda, K., Yang, J., Wang, D., Koo, I., Hao, F., Amin, S. G., Patterson, A. D., Marcus, C. & Perdew, G. H., Jul 1 2023, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37, 7, p. e23010

Research output: Contribution to journalArticlepeer-review

Endogenous Tryptophan-Derived Ah Receptor Ligands are Dissociated from CYP1A1/1B1-Dependent Negative-Feedback

Dong, F., Annalora, A. J., Murray, I. A., Tian, Y., Marcus, C. B., Patterson, A. D. & Perdew, G. H., Jan 1 2023, In: International Journal of Tryptophan Research. 16

Research output: Contribution to journalArticlepeer-review

Alpha-tocopherylquinone differentially modulates claudins to enhance intestinal epithelial tight junction barrier via AhR and Nrf2 pathways

Ganapathy, A. S., Saha, K., Wang, A., Arumugam, P., Dharmaprakash, V., Yochum, G., Koltun, W., Nighot, M., Perdew, G., Thompson, T. A., Ma, T. & Nighot, P., Jul 25 2023, In: Cell Reports. 42, 7, 112705.

Research output: Contribution to journalArticlepeer-review

Third generation quinoline-3-carboxamide transcriptional disrupter of HDAC4, HIF-1α, and MEF-2 signaling for metastatic castration-resistant prostate cancer

Isaacs, J. T., Dalrymple, S. L., Antony, L., Marc Rosen, D., Coleman, I. M., Nelson, P. S., Kostova, M., Murray, I. A., Perdew, G. H., Denmeade, S. R., Akinboye, E. S. & Brennen, W. N., Nov 2023, In: Prostate. 83, 15, p. 1470-1493 24 p.

Research output: Contribution to journalArticlepeer-review

Contribution of Circulating Host and Microbial Tryptophan Metabolites Toward Ah Receptor Activation

Morgan, E. W., Dong, F., Annalora, A. J., Murray, I. A., Wolfe, T., Erickson, R., Gowda, K., Amin, S. G., Petersen, K. S., Kris-Etherton, P. M., Marcus, C. B., Walk, S. T., Patterson, A. D. & Perdew, G. H., Jan 1 2023, In: International Journal of Tryptophan Research. 16

Research output: Contribution to journalArticlepeer-review

Induction of AHR Signaling in Response to the Indolimine Class of Microbial Stress Metabolites

Patel, D., Murray, I. A., Dong, F., Annalora, A. J., Gowda, K., Coslo, D. M., Krzeminski, J., Koo, I., Hao, F., Amin, S. G., Marcus, C. B., Patterson, A. D. & Perdew, G. H., Sep 2023, In: Metabolites. 13, 9, 985.

Research output: Contribution to journalArticlepeer-review

The Ah Receptor from Toxicity to Therapeutics: Report from the 5th AHR Meeting at Penn State University, USA, June 2022

Perdew, G. H., Esser, C., Snyder, M., Sherr, D. H., van den Bogaard, E. H., McGovern, K., Fernández-Salguero, P. M., Coumoul, X. & Patterson, A. D., Mar 2023, In: International journal of molecular sciences. 24, 6, 5550.

Research output: Contribution to journalArticlepeer-review

Lead optimization of aryl hydrocarbon receptor ligands for treatment of inflammatory skin disorders

Rikken, G., Smith, K. J., van den Brink, N. J. M., Smits, J. P. H., Gowda, K., Alnemri, A., Kuzu, G. E., Murray, I. A., Lin, J. M., Smits, J. G. A., van Vlijmen-Willems, I. M., Amin, S. G., Perdew, G. H. & van den Bogaard, E. H., Feb 2023, In: Biochemical Pharmacology. 208, 115400.

Research output: Contribution to journalArticlepeer-review

Alpha-tocopherylquinone-mediated activation of the Aryl Hydrocarbon Receptor regulates the production of inflammation-inducing cytokines and ameliorates intestinal inflammation

Saha, K., Subramenium Ganapathy, A., Wang, A., Arumugam, P., Michael Morris, N., Harris, L., Yochum, G., Koltun, W., Perdew, G. H., Nighot, M., Ma, T. & Nighot, P., 2023, (Accepted/In press) In: Mucosal Immunology.

Research output: Contribution to journalArticlepeer-review

Aryl hydrocarbon receptor activation affects nitrergic neuronal survival and delays intestinal motility in mice

Vijay, A., Boyle, N. R., Kumar, S. M., Perdew, G. H., Srinivasan, S. & Patterson, A. D., Mar 1 2023, In: Toxicological Sciences. 192, 1, p. 117-128 12 p.

Research output: Contribution to journalArticlepeer-review

Aryl Hydrocarbon Receptor Activation Coordinates Mouse Small Intestinal Epithelial Cell Programming

Zhou, X., Chakraborty, D., Murray, I. A., Coslo, D., Kehs, Z., Vijay, A., Ton, C., Desai, D., Amin, S. G., Patterson, A. D. & Perdew, G. H., Feb 1 2023, In: Laboratory Investigation. 103, 2, p. 100012 1 p.

Research output: Contribution to journalArticlepeer-review

AHR is a master regulator of diverse pathways in endogenous metabolism

Granados, J. C., Falah, K., Koo, I., Morgan, E. W., Perdew, G. H., Patterson, A. D., Jamshidi, N. & Nigam, S. K., Dec 2022, In: Scientific reports. 12, 1, 16625.

Research output: Contribution to journalArticlepeer-review

Multi-Omics Strategies for Investigating the Microbiome in Toxicology Research

Morgan, E. W., Perdew, G. H. & Patterson, A. D., Jun 1 2022, In: Toxicological Sciences. 187, 2, p. 189-213 25 p.

Research output: Contribution to journalReview articlepeer-review

Gestational Insulin Resistance Is Mediated by the Gut Microbiome–Indoleamine 2,3-Dioxygenase Axis

Priyadarshini, M., Navarro, G., Reiman, D. J., Sharma, A., Xu, K., Lednovich, K., Manzella, C. R., Khan, M. W., Garcia, M. S., Allard, S., Wicksteed, B., Chlipala, G. E., Szynal, B., Bernabe, B. P., Maki, P. M., Gill, R. K., Perdew, G. H., Gilbert, J., Dai, Y. & Layden, B. T., May 2022, In: Gastroenterology. 162, 6, p. 1675-1689.e11

Research output: Contribution to journalArticlepeer-review