Research Summary
Research focuses on molecular mechanism(s) of toxicity, dioxin-mediated signal transduction, regulation of cellular homeostasis by the Ah receptor, Ah receptor-mediated control of gene expression and biochemistry of heat shock protein complexes. Research is interested in the long-term health effects of persistent exposure to industrial pollutants.
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Recent Publications
Molecular networking identifies an AHR-modulating benzothiazole from white button mushrooms (Agaricus bisporus)
Chen, X., Patterson, A. D., Perdew, G. H., Murray, I. A. & Kellogg, J. J., Jul 2023, In: Journal of Functional Foods. 106, 105602.Research output: Contribution to journal › Article › peer-review
Complex chemical signals dictate Ah receptor activation through the gut-lung axis
Dong, F., Murray, I. A., Annalora, A., Coslo, D. M., Desai, D., Gowda, K., Yang, J., Wang, D., Koo, I., Hao, F., Amin, S. G., Patterson, A. D., Marcus, C. & Perdew, G. H., Jul 1 2023, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37, 7, p. e23010Research output: Contribution to journal › Article › peer-review
Endogenous Tryptophan-Derived Ah Receptor Ligands are Dissociated from CYP1A1/1B1-Dependent Negative-Feedback
Dong, F., Annalora, A. J., Murray, I. A., Tian, Y., Marcus, C. B., Patterson, A. D. & Perdew, G. H., Jan 1 2023, In: International Journal of Tryptophan Research. 16Research output: Contribution to journal › Article › peer-review
Alpha-tocopherylquinone differentially modulates claudins to enhance intestinal epithelial tight junction barrier via AhR and Nrf2 pathways
Ganapathy, A. S., Saha, K., Wang, A., Arumugam, P., Dharmaprakash, V., Yochum, G., Koltun, W., Nighot, M., Perdew, G., Thompson, T. A., Ma, T. & Nighot, P., Jul 25 2023, In: Cell Reports. 42, 7, 112705.Research output: Contribution to journal › Article › peer-review
Third generation quinoline-3-carboxamide transcriptional disrupter of HDAC4, HIF-1α, and MEF-2 signaling for metastatic castration-resistant prostate cancer
Isaacs, J. T., Dalrymple, S. L., Antony, L., Marc Rosen, D., Coleman, I. M., Nelson, P. S., Kostova, M., Murray, I. A., Perdew, G. H., Denmeade, S. R., Akinboye, E. S. & Brennen, W. N., Nov 2023, In: Prostate. 83, 15, p. 1470-1493 24 p.Research output: Contribution to journal › Article › peer-review
Contribution of Circulating Host and Microbial Tryptophan Metabolites Toward Ah Receptor Activation
Morgan, E. W., Dong, F., Annalora, A. J., Murray, I. A., Wolfe, T., Erickson, R., Gowda, K., Amin, S. G., Petersen, K. S., Kris-Etherton, P. M., Marcus, C. B., Walk, S. T., Patterson, A. D. & Perdew, G. H., Jan 1 2023, In: International Journal of Tryptophan Research. 16Research output: Contribution to journal › Article › peer-review
Induction of AHR Signaling in Response to the Indolimine Class of Microbial Stress Metabolites
Patel, D., Murray, I. A., Dong, F., Annalora, A. J., Gowda, K., Coslo, D. M., Krzeminski, J., Koo, I., Hao, F., Amin, S. G., Marcus, C. B., Patterson, A. D. & Perdew, G. H., Sep 2023, In: Metabolites. 13, 9, 985.Research output: Contribution to journal › Article › peer-review
The Ah Receptor from Toxicity to Therapeutics: Report from the 5th AHR Meeting at Penn State University, USA, June 2022
Perdew, G. H., Esser, C., Snyder, M., Sherr, D. H., van den Bogaard, E. H., McGovern, K., Fernández-Salguero, P. M., Coumoul, X. & Patterson, A. D., Mar 2023, In: International journal of molecular sciences. 24, 6, 5550.Research output: Contribution to journal › Article › peer-review
Lead optimization of aryl hydrocarbon receptor ligands for treatment of inflammatory skin disorders
Rikken, G., Smith, K. J., van den Brink, N. J. M., Smits, J. P. H., Gowda, K., Alnemri, A., Kuzu, G. E., Murray, I. A., Lin, J. M., Smits, J. G. A., van Vlijmen-Willems, I. M., Amin, S. G., Perdew, G. H. & van den Bogaard, E. H., Feb 2023, In: Biochemical Pharmacology. 208, 115400.Research output: Contribution to journal › Article › peer-review
Alpha-tocopherylquinone-mediated activation of the Aryl Hydrocarbon Receptor regulates the production of inflammation-inducing cytokines and ameliorates intestinal inflammation
Saha, K., Subramenium Ganapathy, A., Wang, A., Arumugam, P., Michael Morris, N., Harris, L., Yochum, G., Koltun, W., Perdew, G. H., Nighot, M., Ma, T. & Nighot, P., 2023, (Accepted/In press) In: Mucosal Immunology.Research output: Contribution to journal › Article › peer-review
Aryl hydrocarbon receptor activation affects nitrergic neuronal survival and delays intestinal motility in mice
Vijay, A., Boyle, N. R., Kumar, S. M., Perdew, G. H., Srinivasan, S. & Patterson, A. D., Mar 1 2023, In: Toxicological Sciences. 192, 1, p. 117-128 12 p.Research output: Contribution to journal › Article › peer-review
Aryl Hydrocarbon Receptor Activation Coordinates Mouse Small Intestinal Epithelial Cell Programming
Zhou, X., Chakraborty, D., Murray, I. A., Coslo, D., Kehs, Z., Vijay, A., Ton, C., Desai, D., Amin, S. G., Patterson, A. D. & Perdew, G. H., Feb 1 2023, In: Laboratory Investigation. 103, 2, p. 100012 1 p.Research output: Contribution to journal › Article › peer-review
AHR is a master regulator of diverse pathways in endogenous metabolism
Granados, J. C., Falah, K., Koo, I., Morgan, E. W., Perdew, G. H., Patterson, A. D., Jamshidi, N. & Nigam, S. K., Dec 2022, In: Scientific reports. 12, 1, 16625.Research output: Contribution to journal › Article › peer-review
Multi-Omics Strategies for Investigating the Microbiome in Toxicology Research
Morgan, E. W., Perdew, G. H. & Patterson, A. D., Jun 1 2022, In: Toxicological Sciences. 187, 2, p. 189-213 25 p.Research output: Contribution to journal › Review article › peer-review
Gestational Insulin Resistance Is Mediated by the Gut Microbiome–Indoleamine 2,3-Dioxygenase Axis
Priyadarshini, M., Navarro, G., Reiman, D. J., Sharma, A., Xu, K., Lednovich, K., Manzella, C. R., Khan, M. W., Garcia, M. S., Allard, S., Wicksteed, B., Chlipala, G. E., Szynal, B., Bernabe, B. P., Maki, P. M., Gill, R. K., Perdew, G. H., Gilbert, J., Dai, Y. & Layden, B. T., May 2022, In: Gastroenterology. 162, 6, p. 1675-1689.e11Research output: Contribution to journal › Article › peer-review