Gary Perdew

Director of the Center for Molecular Toxicology & Carcinogenesis
Titles and Affiliations
John T. And Paige S. Smith Professor, Veterinary and Biomedical Sciences

Research Summary

Research focuses on molecular mechanism(s) of toxicity, dioxin-mediated signal transduction, regulation of cellular homeostasis by the Ah receptor, Ah receptor-mediated control of gene expression and biochemistry of heat shock protein complexes. Research is interested in the long-term health effects of persistent exposure to industrial pollutants.

In the News

Research Keywords

Recent Publications

AHR is a master regulator of diverse pathways in endogenous metabolism

Granados, J. C., Falah, K., Koo, I., Morgan, E. W., Perdew, G. H., Patterson, A. D., Jamshidi, N. & Nigam, S. K., Dec 2022, In: Scientific reports. 12, 1, 16625.

Research output: Contribution to journalArticlepeer-review

Multi-Omics Strategies for Investigating the Microbiome in Toxicology Research

Morgan, E. W., Perdew, G. H. & Patterson, A. D., May 26 2022, In: Toxicological sciences : an official journal of the Society of Toxicology. 187, 2, p. 189-213 25 p.

Research output: Contribution to journalReview articlepeer-review

Gestational Insulin Resistance Is Mediated by the Gut Microbiome–Indoleamine 2,3-Dioxygenase Axis

Priyadarshini, M., Navarro, G., Reiman, D. J., Sharma, A., Xu, K., Lednovich, K., Manzella, C. R., Khan, M. W., Garcia, M. S., Allard, S., Wicksteed, B., Chlipala, G. E., Szynal, B., Bernabe, B. P., Maki, P. M., Gill, R. K., Perdew, G. H., Gilbert, J., Dai, Y. & Layden, B. T., May 2022, In: Gastroenterology. 162, 6, p. 1675-1689.e11

Research output: Contribution to journalArticlepeer-review

Early Life Short-Term Exposure to Polychlorinated Biphenyl 126 in Mice Leads to Metabolic Dysfunction and Microbiota Changes in Adulthood

Tian, Y., Rimal, B., Gui, W., Koo, I., Yokoyama, S., Perdew, G. H. & Patterson, A. D., Aug 2022, In: International journal of molecular sciences. 23, 15, 8220.

Research output: Contribution to journalArticlepeer-review

The aryl hydrocarbon receptor activates ceramide biosynthesis in mice contributing to hepatic lipogenesis

Liu, Q., Zhang, L., Allman, E. L., Hubbard, T. D., Murray, I. A., Hao, F., Tian, Y., Gui, W., Nichols, R. G., Smith, P. B., Anitha, M., Perdew, G. H. & Patterson, A. D., Jun 30 2021, In: Toxicology. 458, 152831.

Research output: Contribution to journalArticlepeer-review

The aryl hydrocarbon receptor at the forefront of host-microbe interactions in the skin: A perspective on current knowledge gaps and directions for future research and therapeutic applications

van den Bogaard, E. H., Esser, C. & Perdew, G. H., Oct 2021, In: Experimental Dermatology. 30, 10, p. 1477-1483 7 p.

Research output: Contribution to journalArticlepeer-review

The Enigma of AHR Activation in the Skin: Interplay among Ligands, Metabolism, and Bioavailability

van den Bogaard, E. H. & Perdew, G. H., Jun 2021, In: Journal of Investigative Dermatology. 141, 6, p. 1385-1388 4 p.

Research output: Contribution to journalComment/debatepeer-review

Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity

Dong, F., Hao, F., Murray, I. A., Smith, P. B., Koo, I., Tindall, A. M., Kris-Etherton, P. M., Gowda, K., Amin, S. G., Patterson, A. D. & Perdew, G. H., Nov 9 2020, In: Gut microbes. 12, 1, p. 1-24 24 p.

Research output: Contribution to journalArticlepeer-review

The aryl hydrocarbon receptor as a mediator of host-microbiota interplay

Dong, F. & Perdew, G. H., 2020, In: Gut microbes. 12, 1, 1859812.

Research output: Contribution to journalReview articlepeer-review

Targeting the pregnane X receptor using microbial metabolite mimicry

Dvořák, Z., Kopp, F., Costello, C. M., Kemp, J. S., Li, H., Vrzalová, A., Štěpánková, M., Bartoňková, I., Jiskrová, E., Poulíková, K., Vyhlídalová, B., Nordstroem, L. U., Karunaratne, C. V., Ranhotra, H. S., Mun, K. S., Naren, A. P., Murray, I. A., Perdew, G. H., Brtko, J., Toporova, L., & 22 othersSchön, A., Wallace, W. G., Walton, W. G., Redinbo, M. R., Sun, K., Beck, A., Kortagere, S., Neary, M. C., Chandran, A., Vishveshwara, S., Cavalluzzi, M. M., Lentini, G., Cui, J. Y., Gu, H., March, J. C., Chatterjee, S., Matson, A., Wright, D., Flannigan, K. L., Hirota, S. A., Sartor, R. B. & Mani, S., Apr 7 2020, In: EMBO Molecular Medicine. 12, 4, e11621.

Research output: Contribution to journalArticlepeer-review

PCB126 blocks the thermogenic beiging response of adipocytes

Gourronc, F. A., Perdew, G. H., Robertson, L. W. & Klingelhutz, A. J., Mar 1 2020, In: Environmental Science and Pollution Research. 27, 9, p. 8897-8904 8 p.

Research output: Contribution to journalArticlepeer-review

Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity

Muku, G. E., Kusnadi, A., Kuzu, G., Tanos, R., Murray, I. A., Gowda, K., Amin, S. & Perdew, G. H., Feb 1 2020, In: Laboratory Investigation. 100, 2, p. 250-264 15 p.

Research output: Contribution to journalArticlepeer-review

How ah receptor ligand specificity became important in understanding its physiological function

Murray, I. A. & Perdew, G. H., Dec 2 2020, In: International journal of molecular sciences. 21, 24, p. 1-19 19 p., 9614.

Research output: Contribution to journalReview articlepeer-review

Metatranscriptomic analysis of the mouse gut microbiome response to the persistent organic pollutant 2,3,7,8-tetrachlorodibenzofuran

Nichols, R. G., Zhang, J., Cai, J., Murray, I. A., Koo, I., Smith, P. B., Perdew, G. H. & Patterson, A. D., Jan 2020, In: Metabolites. 10, 1, 1.

Research output: Contribution to journalArticlepeer-review

β-Naphthoflavone activation of the Ah receptor alleviates irradiation-induced intestinal injury in mice

Zhou, X., Li, D., Xu, W., Zhang, H., Wang, H. & Perdew, G. H., Dec 2020, In: Antioxidants. 9, 12, p. 1-14 14 p., 1264.

Research output: Contribution to journalArticlepeer-review