Gary Perdew

Profile Photo
Image
Email
IEE Research Themes
Director of the Center for Molecular Toxicology & Carcinogenesis
Titles and Affiliations
John T. And Paige S. Smith Professor, Veterinary and Biomedical Sciences

Research Summary

Research focuses on molecular mechanism(s) of toxicity, dioxin-mediated signal transduction, regulation of cellular homeostasis by the Ah receptor, Ah receptor-mediated control of gene expression and biochemistry of heat shock protein complexes. Research is interested in the long-term health effects of persistent exposure to industrial pollutants.

Research Keywords

Recent Publications

The aryl hydrocarbon receptor activates ceramide biosynthesis in mice contributing to hepatic lipogenesis

Liu, Q., Zhang, L., Allman, E. L., Hubbard, T. D., Murray, I. A., Hao, F., Tian, Y., Gui, W., Nichols, R. G., Smith, P. B., Anitha, M., Perdew, G. H. & Patterson, A. D., Jun 30 2021, In: Toxicology. 458, 152831.

Research output: Contribution to journalArticlepeer-review

Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity

Dong, F., Hao, F., Murray, I. A., Smith, P. B., Koo, I., Tindall, A. M., Kris-Etherton, P. M., Gowda, K., Amin, S. G., Patterson, A. D. & Perdew, G. H., Nov 9 2020, In: Gut microbes. 12, 1, p. 1-24 24 p.

Research output: Contribution to journalArticlepeer-review

The aryl hydrocarbon receptor as a mediator of host-microbiota interplay

Dong, F. & Perdew, G. H., 2020, In: Gut microbes. 12, 1, 1859812.

Research output: Contribution to journalReview articlepeer-review

Targeting the pregnane X receptor using microbial metabolite mimicry

Dvořák, Z., Kopp, F., Costello, C. M., Kemp, J. S., Li, H., Vrzalová, A., Štěpánková, M., Bartoňková, I., Jiskrová, E., Poulíková, K., Vyhlídalová, B., Nordstroem, L. U., Karunaratne, C. V., Ranhotra, H. S., Mun, K. S., Naren, A. P., Murray, I. A., Perdew, G. H., Brtko, J., Toporova, L. & 22 others, Schön, A., Wallace, W. G., Walton, W. G., Redinbo, M. R., Sun, K., Beck, A., Kortagere, S., Neary, M. C., Chandran, A., Vishveshwara, S., Cavalluzzi, M. M., Lentini, G., Cui, J. Y., Gu, H., March, J. C., Chatterjee, S., Matson, A., Wright, D., Flannigan, K. L., Hirota, S. A., Sartor, R. B. & Mani, S., Apr 7 2020, In: EMBO Molecular Medicine. 12, 4, e11621.

Research output: Contribution to journalArticlepeer-review

PCB126 blocks the thermogenic beiging response of adipocytes

Gourronc, F. A., Perdew, G. H., Robertson, L. W. & Klingelhutz, A. J., Mar 1 2020, In: Environmental Science and Pollution Research. 27, 9, p. 8897-8904 8 p.

Research output: Contribution to journalArticlepeer-review

Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity

Muku, G. E., Kusnadi, A., Kuzu, G., Tanos, R., Murray, I. A., Gowda, K., Amin, S. & Perdew, G. H., Feb 1 2020, In: Laboratory Investigation. 100, 2, p. 250-264 15 p.

Research output: Contribution to journalArticlepeer-review

How ah receptor ligand specificity became important in understanding its physiological function

Murray, I. A. & Perdew, G. H., Dec 2 2020, In: International journal of molecular sciences. 21, 24, p. 1-19 19 p., 9614.

Research output: Contribution to journalReview articlepeer-review

Metatranscriptomic analysis of the mouse gut microbiome response to the persistent organic pollutant 2,3,7,8-tetrachlorodibenzofuran

Nichols, R. G., Zhang, J., Cai, J., Murray, I. A., Koo, I., Smith, P. B., Perdew, G. H. & Patterson, A. D., Jan 2020, In: Metabolites. 10, 1, 1.

Research output: Contribution to journalArticlepeer-review

β-Naphthoflavone activation of the Ah receptor alleviates irradiation-induced intestinal injury in mice

Zhou, X., Li, D., Xu, W., Zhang, H., Wang, H. & Perdew, G. H., Dec 2020, In: Antioxidants. 9, 12, p. 1-14 14 p., 1264.

Research output: Contribution to journalArticlepeer-review

Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline

Hubbard, T. D., Liu, Q., Murray, I. A., Dong, F., Miller, C., Smith, P. B., Gowda, K., Lin, J. M., Amin, S., Patterson, A. D. & Perdew, G. H., Apr 5 2019, In: Journal of Proteome Research. 18, 4, p. 1715-1724 10 p.

Research output: Contribution to journalArticlepeer-review