Research Summary
Research focuses on molecular mechanism(s) of toxicity, dioxin-mediated signal transduction, regulation of cellular homeostasis by the Ah receptor, Ah receptor-mediated control of gene expression and biochemistry of heat shock protein complexes. Research is interested in the long-term health effects of persistent exposure to industrial pollutants.
In the News
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Recent Publications
The Janus-facedness of the aryl hydrocarbon receptor pathway Report of the 6th International AHR Meeting: Research, Prevention, Therapy
Haarmann-Stemmann, T., Reichert, D., Coumoul, X., Lawrence, B. P., Perdew, G. H., Sherr, D. H., Weighardt, H., Rolfes, K. M. & Esser, C., Apr 2025, In: Biochemical Pharmacology. 234, 116808.Research output: Contribution to journal › Review article › peer-review
Modulation of Ceramide-Induced Apoptosis in Enteric Neurons by Aryl Hydrocarbon Receptor Signaling: Unveiling a New Pathway beyond ER Stress
Anitha, M., Kumar, S. M., Koo, I., Perdew, G. H., Srinivasan, S. & Patterson, A. D., Aug 2024, In: International journal of molecular sciences. 25, 16, 8581.Research output: Contribution to journal › Article › peer-review
Immune cell-intrinsic Ah receptor facilitates the expression of antimicrobial REG3G in the small intestine
Chakraborty, D., Coslo, D. M., Murray, I. A., Vijay, A., Patterson, A. D. & Perdew, G. H., Feb 29 2024, In: FASEB Journal. 38, 4, e23471.Research output: Contribution to journal › Article › peer-review
Species differences in specific ligand-binding affinity and activation of AHR: The biological basis for calculation of relative effective potencies and toxic equivalence factors
Eaton, D. L., Simon, T. W., Kaminski, N. E., Perdew, G. H. & Nebert, D. W., May 2024, In: Regulatory Toxicology and Pharmacology. 149, 105598.Research output: Contribution to journal › Review article › peer-review
The 2022 revised WHO TEFs for dioxins and dioxin-like chemicals: The importance of considering the use of species-specific information to determine relative effective potency for human-based risk assessment
Eaton, D. L., Simon, T. W., Kaminski, N. E., Perdew, G. H. & Nebert, D. W., May 2024, In: Regulatory Toxicology and Pharmacology. 149, 105599.Research output: Contribution to journal › Comment/debate › peer-review
Effects of Early Life Exposures to the Aryl Hydrocarbon Receptor Ligand TCDF on Gut Microbiota and Host Metabolic Homeostasis in C57BL/6J Mice
Tian, Y., Rimal, B., Bisanz, J. E., Gui, W., Wolfe, T. M., Koo, I., Murray, I. A., Nettleford, S. K., Yokoyama, S., Dong, F., Koshkin, S., Prabhu, K. S., Turnbaugh, P. J., Walk, S. T., Perdew, G. H. & Patterson, A. D., Aug 2024, In: Environmental health perspectives. 132, 8, 087005.Research output: Contribution to journal › Article › peer-review
Sphingosine Kinase 2 Regulates Aryl Hydrocarbon Receptor Nuclear Translocation and Target Gene Activation
Yokoyama, S., Koo, I., Aibara, D., Tian, Y., Murray, I. A., Collins, S. L., Coslo, D. M., Kono, M., Peters, J. M., Proia, R. L., Gonzalez, F. J., Perdew, G. H. & Patterson, A. D., Oct 28 2024, In: Advanced Science. 11, 40, 2400794.Research output: Contribution to journal › Article › peer-review
Activation of Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) in Keratinocytes by Endogenous Fatty Acids
Zhu, B., Zhu, X., Borland, M. G., Ralph, D. H., Chiaro, C. R., Krausz, K. W., Ntambi, J. M., Glick, A. B., Patterson, A. D., Perdew, G. H., Gonzalez, F. J. & Peters, J. M., Jun 2024, In: Biomolecules. 14, 6, 606.Research output: Contribution to journal › Article › peer-review
Molecular networking identifies an AHR-modulating benzothiazole from white button mushrooms (Agaricus bisporus)
Chen, X., Patterson, A. D., Perdew, G. H., Murray, I. A. & Kellogg, J. J., Jul 2023, In: Journal of Functional Foods. 106, 105602.Research output: Contribution to journal › Article › peer-review
Complex chemical signals dictate Ah receptor activation through the gut-lung axis
Dong, F., Murray, I. A., Annalora, A., Coslo, D. M., Desai, D., Gowda, K., Yang, J., Wang, D., Koo, I., Hao, F., Amin, S. G., Patterson, A. D., Marcus, C. & Perdew, G. H., Jul 1 2023, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37, 7, p. e23010Research output: Contribution to journal › Article › peer-review
Endogenous Tryptophan-Derived Ah Receptor Ligands are Dissociated from CYP1A1/1B1-Dependent Negative-Feedback
Dong, F., Annalora, A. J., Murray, I. A., Tian, Y., Marcus, C. B., Patterson, A. D. & Perdew, G. H., Jan 1 2023, In: International Journal of Tryptophan Research. 16Research output: Contribution to journal › Article › peer-review
Alpha-tocopherylquinone differentially modulates claudins to enhance intestinal epithelial tight junction barrier via AhR and Nrf2 pathways
Ganapathy, A. S., Saha, K., Wang, A., Arumugam, P., Dharmaprakash, V., Yochum, G., Koltun, W., Nighot, M., Perdew, G., Thompson, T. A., Ma, T. & Nighot, P., Jul 25 2023, In: Cell Reports. 42, 7, 112705.Research output: Contribution to journal › Article › peer-review
Third generation quinoline-3-carboxamide transcriptional disrupter of HDAC4, HIF-1α, and MEF-2 signaling for metastatic castration-resistant prostate cancer
Isaacs, J. T., Dalrymple, S. L., Antony, L., Marc Rosen, D., Coleman, I. M., Nelson, P. S., Kostova, M., Murray, I. A., Perdew, G. H., Denmeade, S. R., Akinboye, E. S. & Brennen, W. N., Nov 2023, In: Prostate. 83, 15, p. 1470-1493 24 p.Research output: Contribution to journal › Article › peer-review
Contribution of Circulating Host and Microbial Tryptophan Metabolites Toward Ah Receptor Activation
Morgan, E. W., Dong, F., Annalora, A. J., Murray, I. A., Wolfe, T., Erickson, R., Gowda, K., Amin, S. G., Petersen, K. S., Kris-Etherton, P. M., Marcus, C. B., Walk, S. T., Patterson, A. D. & Perdew, G. H., Jan 1 2023, In: International Journal of Tryptophan Research. 16Research output: Contribution to journal › Article › peer-review
Induction of AHR Signaling in Response to the Indolimine Class of Microbial Stress Metabolites
Patel, D., Murray, I. A., Dong, F., Annalora, A. J., Gowda, K., Coslo, D. M., Krzeminski, J., Koo, I., Hao, F., Amin, S. G., Marcus, C. B., Patterson, A. D. & Perdew, G. H., Sep 2023, In: Metabolites. 13, 9, 985.Research output: Contribution to journal › Article › peer-review