Costas Maranas

Affiliate Researcher
Titles and Affiliations
Donald B. Broughton Professor, Chemical Engineering

Research Summary

Research interests include modeling/optimization of directed evolution protocols for protein engineering, optimization in metabolic engineering and bioinformatics, molecular and product design, and supply chain planning and scheduling.

In the News

Research Keywords

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Projects

Recent Publications

De novo design and Rosetta-based assessment of high-affinity antibody variable regions (Fv) against the SARS-CoV-2 spike receptor binding domain (RBD)

Boorla, V. S., Chowdhury, R., Ramasubramanian, R., Ameglio, B., Frick, R., Gray, J. J. & Maranas, C. D., Feb 2023, In: Proteins: Structure, Function and Bioinformatics. 91, 2, p. 196-208 13 p.

Research output: Contribution to journal › Article › peer-review

Little Brown Bats (Myotis lucifugus) Support the Binding of SARS-CoV-2 Spike and Are Likely Susceptible to SARS-CoV-2 Infection

Chothe, S. K., Jakka, P., Boorla, V. S., Ramasamy, S., Gontu, A., Nissly, R. H., Brown, J., Turner, G., Sewall, B. J., Reeder, D. A. M., Field, K. A., Engiles, J. B., Amirthalingam, S., Ravichandran, A., LaBella, L., Nair, M. S., Maranas, C. D. & Kuchipudi, S. V., May 2023, In: Viruses. 15, 5, 1103.

Research output: Contribution to journal › Article › peer-review

Evaluating proteome allocation of Saccharomyces cerevisiae phenotypes with resource balance analysis

Dinh, H. V. & Maranas, C. D., May 2023, In: Metabolic engineering. 77, p. 242-255 14 p.

Research output: Contribution to journal › Article › peer-review

Comparative study of two Saccharomyces cerevisiae strains with kinetic models at genome-scale

Hu, M., Dinh, H. V., Shen, Y., Suthers, P. F., Foster, C. J., Call, C. M., Ye, X., Pratas, J., Fatma, Z., Zhao, H., Rabinowitz, J. D. & Maranas, C. D., Mar 2023, In: Metabolic engineering. 76, p. 1-17 17 p.

Research output: Contribution to journal › Article › peer-review

A detailed genome-scale metabolic model of Clostridium thermocellum investigates sources of pyrophosphate for driving glycolysis

Schroeder, W. L., Kuil, T., van Maris, A. J. A., Olson, D. G., Lynd, L. R. & Maranas, C. D., May 2023, In: Metabolic engineering. 77, p. 306-322 17 p.

Research output: Contribution to journal › Article › peer-review

Metabolic engineering of low-pH-tolerant non-model yeast, Issatchenkia orientalis, for production of citramalate

Wu, Z. Y., Sun, W., Shen, Y., Pratas, J., Suthers, P. F., Hsieh, P. H., Dwaraknath, S., Rabinowitz, J. D., Maranas, C. D., Shao, Z. & Yoshikuni, Y., Jun 2023, In: Metabolic Engineering Communications. 16, e00220.

Research output: Contribution to journal › Article › peer-review

EnZymClass: Substrate specificity prediction tool of plant acyl-ACP thioesterases based on ensemble learning

Banerjee, D., Jindra, M. A., Linot, A. J., Pfleger, B. F. & Maranas, C. D., Jan 2022, In: Current Research in Biotechnology. 4, p. 1-9 9 p.

Research output: Contribution to journal › Article › peer-review

ML helps predict enzyme turnover rates

Boorla, V. S., Upadhyay, V. & Maranas, C. D., Aug 2022, In: Nature Catalysis. 5, 8, p. 655-657 3 p.

Research output: Contribution to journal › Comment/debate › peer-review

Dissecting the metabolic reprogramming of maize root under nitrogen-deficient stress conditions

Chowdhury, N. B., Schroeder, W. L., Sarkar, D., Amiour, N., Quilleré, I., Hirel, B., Maranas, C. D. & Saha, R., Jan 5 2022, In: Journal of experimental botany. 73, 1, p. 275-291 17 p.

Research output: Contribution to journal › Article › peer-review

Quantifying the propagation of parametric uncertainty on flux balance analysis

Dinh, H. V., Sarkar, D. & Maranas, C. D., Jan 2022, In: Metabolic engineering. 69, p. 26-39 14 p.

Research output: Contribution to journal › Article › peer-review

Assessing the impact of substrate-level enzyme regulations limiting ethanol titer in Clostridium thermocellum using a core kinetic model

Foster, C., Boorla, V. S., Dash, S., Gopalakrishnan, S., Jacobson, T. B., Olson, D. G., Amador-Noguez, D., Lynd, L. R. & Maranas, C. D., Jan 2022, In: Metabolic engineering. 69, p. 286-301 16 p.

Research output: Contribution to journal › Article › peer-review

Development and Validation of Indirect Enzyme-Linked Immunosorbent Assays for Detecting Antibodies to SARS-CoV-2 in Cattle, Swine, and Chicken

Gontu, A., Marlin, E. A., Ramasamy, S., Neerukonda, S., Anil, G., Morgan, J., Quraishi, M., Chen, C., Boorla, V. S., Nissly, R. H., Jakka, P., Chothe, S. K., Ravichandran, A., Kodali, N., Amirthalingam, S., Labella, L., Kelly, K., Natesan, P., Minns, A. M., Rossi, R. M., & 9 othersWerner, J. R., Hovingh, E., Lindner, S. E., Tewari, D., Kapur, V., Vandegrift, K. J., Maranas, C. D., Nair, M. S. & Kuchipudi, S. V., Jul 2022, In: Viruses. 14, 7, 1358.

Research output: Contribution to journal › Article › peer-review

Multiple spillovers from humans and onward transmission of SARS-CoV-2 in white-tailed deer

Kuchipudi, S. V., Surendran-Nair, M., Ruden, R. M., Yon, M., Nissly, R. H., Vandegrift, K. J., Nelli, R. K., Li, L., Jayarao, B. M., Maranas, C. D., Levine, N., Willgert, K., Conlan, A. J. K., Olsen, R. J., Davis, J. J., Musser, J. M., Hudson, P. J. & Kapur, V., Feb 8 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 6, e2121644119.

Research output: Contribution to journal › Article › peer-review

Functional Analysis of H+-Pumping Membrane-Bound Pyrophosphatase, ADP-Glucose Synthase, and Pyruvate Phosphate Dikinase as Pyrophosphate Sources in Clostridium thermocellum

Kuil, T., Hon, S., Yayo, J., Foster, C., Ravagnan, G., Maranas, C. D., Lynd, L. R., Olson, D. G. & van Maris, A. J. A., Feb 2022, In: Applied and environmental microbiology. 88, 4, e01857.

Research output: Contribution to journal › Article › peer-review

Toward low-cost biological and hybrid biological/catalytic conversion of cellulosic biomass to fuels†

Lynd, L. R., Beckham, G. T., Guss, A. M., Jayakody, L. N., Karp, E. M., Maranas, C., McCormick, R. L., Amador-Noguez, D., Bomble, Y. J., Davison, B. H., Foster, C., Himmel, M. E., Holwerda, E. K., Laser, M. S., Ng, C. Y., Olson, D. G., Román-Leshkov, Y., Trinh, C. T., Tuskan, G. A., Upadhayay, V., & 3 othersVardon, D. R., Wang, L. & Wyman, C. E., Feb 9 2022, In: Energy and Environmental Science. 15, 3, p. 938-990 53 p.

Research output: Contribution to journal › Review article › peer-review