Costas Maranas

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Affiliate Researcher
Titles and Affiliations
Donald B. Broughton Professor, Chemical Engineering

Research Summary

Research interests include modeling/optimization of directed evolution protocols for protein engineering, optimization in metabolic engineering and bioinformatics, molecular and product design, and supply chain planning and scheduling.

Research Keywords

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Recent Publications

Building kinetic models for metabolic engineering

Foster, C. J., Wang, L., Dinh, H. V., Suthers, P. F. & Maranas, C. D., Feb 2021, In: Current Opinion in Biotechnology. 67, p. 35-41 7 p.

Research output: Contribution to journalReview articlepeer-review

A genome-scale metabolic model of anabaena 33047 to guide genetic modifications to overproduce nylon monomers

Hendry, J. I., Dinh, H. V., Sarkar, D., Wang, L., Bandyopadhyay, A., Pakrasi, H. B. & Maranas, C. D., Mar 2021, In: Metabolites. 11, 3, 168.

Research output: Contribution to journalArticlepeer-review

Engineering biology approaches for food and nutrient production by cyanobacteria

Liu, D., Liberton, M., Hendry, J. I., Aminian-Dehkordi, J., Maranas, C. D. & Pakrasi, H. B., Feb 2021, In: Current Opinion in Biotechnology. 67, p. 1-6 6 p.

Research output: Contribution to journalReview articlepeer-review

Elucidation of trophic interactions in an unusual single-cell nitrogen-fixing symbiosis using metabolic modeling

Sarkar, D., Landa, M., Bandyopadhyay, A., Pakrasi, H. B., Zehr, J. P. & Maranas, C. D., May 2021, In: PLoS computational biology. 17, 5, e1008983.

Research output: Contribution to journalArticlepeer-review

Recent advances in constraint and machine learning-based metabolic modeling by leveraging stoichiometric balances, thermodynamic feasibility and kinetic law formalisms

Suthers, P. F., Foster, C. J., Sarkar, D., Wang, L. & Maranas, C. D., Jan 2021, In: Metabolic engineering. 63, p. 13-33 21 p.

Research output: Contribution to journalArticlepeer-review

Computationally Prospecting Potential Pathways from Lignin Monomers and Dimers toward Aromatic Compounds

Wang, L. & Maranas, C. D., May 21 2021, In: ACS Synthetic Biology. 10, 5, p. 1064-1076 13 p.

Research output: Contribution to journalArticlepeer-review

Bacterial colonization reprograms the neonatal gut metabolome

Bittinger, K., Zhao, C., Li, Y., Ford, E., Friedman, E. S., Ni, J., Kulkarni, C. V., Cai, J., Tian, Y., Liu, Q., Patterson, A. D., Sarkar, D., Chan, S. H. J., Maranas, C., Saha-Shah, A., Lund, P., Garcia, B. A., Mattei, L. M., Gerber, J. S., Elovitz, M. A. & 9 others, Kelly, A., DeRusso, P., Kim, D., Hofstaedter, C. E., Goulian, M., Li, H., Bushman, F. D., Zemel, B. S. & Wu, G. D., Jun 1 2020, In: Nature Microbiology. 5, 6, p. 838-847 10 p.

Research output: Contribution to journalArticlepeer-review

Computational biophysical characterization of the SARS-CoV-2 spike protein binding with the ACE2 receptor and implications for infectivity

Chowdhury, R., Boorla, V. S. & Maranas, C. D., 2020, In: Computational and Structural Biotechnology Journal. 18, p. 2573-2582 10 p.

Research output: Contribution to journalArticlepeer-review

From directed evolution to computational enzyme engineering—A review

Chowdhury, R. & Maranas, C. D., Mar 1 2020, In: AIChE Journal. 66, 3, e16847.

Research output: Contribution to journalArticlepeer-review

IPRO+/−: Computational Protein Design Tool Allowing for Insertions and Deletions

Chowdhury, R., Grisewood, M. J., Boorla, V. S., Yan, Q., Pfleger, B. F. & Maranas, C. D., Dec 1 2020, In: Structure. 28, 12, p. 1344-1357.e4

Research output: Contribution to journalArticlepeer-review