Costas Maranas

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Titles and Affiliations
Donald B. Broughton Professor, Chemical Engineering

Research Summary

Research interests include modeling/optimization of directed evolution protocols for protein engineering, optimization in metabolic engineering and bioinformatics, molecular and product design, and supply chain planning and scheduling.

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Recent Publications

Quantifying the propagation of parametric uncertainty on flux balance analysis

Dinh, H. V., Sarkar, D. & Maranas, C. D., Jan 2022, In: Metabolic engineering. 69, p. 26-39 14 p.

Research output: Contribution to journalArticlepeer-review

Computational prediction of the effect of amino acid changes on the binding affinity between SARS-CoV-2 spike RBD and human ACE2

Chen, C., Boorla, V. S., Banerjee, D., Chowdhury, R., Cavener, V. S., Nissly, R. H., Gontu, A., Boyle, N. R., Vandegrift, K., Nair, M. S., Kuchipudi, S. V. & Maranas, C. D., Oct 19 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 42, e2106480118.

Research output: Contribution to journalArticlepeer-review

Building kinetic models for metabolic engineering

Foster, C. J., Wang, L., Dinh, H. V., Suthers, P. F. & Maranas, C. D., Feb 2021, In: Current Opinion in Biotechnology. 67, p. 35-41 7 p.

Research output: Contribution to journalReview articlepeer-review

A genome-scale metabolic model of anabaena 33047 to guide genetic modifications to overproduce nylon monomers

Hendry, J. I., Dinh, H. V., Sarkar, D., Wang, L., Bandyopadhyay, A., Pakrasi, H. B. & Maranas, C. D., Mar 2021, In: Metabolites. 11, 3, 168.

Research output: Contribution to journalArticlepeer-review

Engineering biology approaches for food and nutrient production by cyanobacteria

Liu, D., Liberton, M., Hendry, J. I., Aminian-Dehkordi, J., Maranas, C. D. & Pakrasi, H. B., Feb 2021, In: Current Opinion in Biotechnology. 67, p. 1-6 6 p.

Research output: Contribution to journalReview articlepeer-review

Recombination and lineage-specific mutations linked to the emergence of SARS-CoV-2

Patiño-Galindo, J. Á., Filip, I., Chowdhury, R., Maranas, C. D., Sorger, P. K., AlQuraishi, M. & Rabadan, R., Dec 2021, In: Genome Medicine. 13, 1, 124.

Research output: Contribution to journalArticlepeer-review

Elucidation of trophic interactions in an unusual single-cell nitrogen-fixing symbiosis using metabolic modeling

Sarkar, D., Landa, M., Bandyopadhyay, A., Pakrasi, H. B., Zehr, J. P. & Maranas, C. D., May 2021, In: PLoS computational biology. 17, 5, e1008983.

Research output: Contribution to journalArticlepeer-review

Recent advances in constraint and machine learning-based metabolic modeling by leveraging stoichiometric balances, thermodynamic feasibility and kinetic law formalisms

Suthers, P. F., Foster, C. J., Sarkar, D., Wang, L. & Maranas, C. D., Jan 2021, In: Metabolic engineering. 63, p. 13-33 21 p.

Research output: Contribution to journalArticlepeer-review

Computationally Prospecting Potential Pathways from Lignin Monomers and Dimers toward Aromatic Compounds

Wang, L. & Maranas, C. D., May 21 2021, In: ACS Synthetic Biology. 10, 5, p. 1064-1076 13 p.

Research output: Contribution to journalArticlepeer-review

dGPredictor: Automated fragmentation method for metabolic reaction free energy prediction and de novo pathway design

Wang, L., Upadhyay, V. & Maranas, C. D., Sep 2021, In: PLoS computational biology. 17, 9, e1009448.

Research output: Contribution to journalArticlepeer-review