Research Summary
Current research activities are focused in three distinct areas: artificial organs, bioseparations and membrane processes with the goal is of developing a more fundamental understanding of the factors governing the behavior of these processes, including t
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Recent Publications
Effect of filtrate flux and process disruptions on virus retention by a relatively homogeneous virus removal membrane
Afzal, M. A. & Zydney, A. L., Jul 1 2022, In: Biotechnology progress. 38, 4, e3255.Research output: Contribution to journal › Article › peer-review
Role of membrane structure on the filtrate flux during monoclonal antibody filtration through virus retentive membranes
Billups, M., Minervini, M., Holstein, M., Feroz, H., Ranjan, S., Hung, J., Bao, H., Li, Z. J., Ghose, S. & Zydney, A. L., Mar 1 2022, In: Biotechnology progress. 38, 2, e3231.Research output: Contribution to journal › Article › peer-review
Retention and Fouling during Nanoparticle Filtration: Implications for Membrane Purification of Biotherapeutics
Chu, L. K., Wickramasinghe, S. R., Qian, X. & Zydney, A. L., Mar 2022, In: Membranes. 12, 3, 299.Research output: Contribution to journal › Article › peer-review
Scale-up issues during sterile filtration of glycoconjugate vaccines
Du, Z., Motevalian, S. P., Carrillo Conde, B., Reilly, K. & Zydney, A. L., Jul 1 2022, In: Biotechnology progress. 38, 4, e3260.Research output: Contribution to journal › Article › peer-review
Process-and Product-Related Foulants in Virus Filtration
Isu, S., Qian, X., Zydney, A. L. & Wickramasinghe, S. R., Apr 2022, In: Bioengineering. 9, 4, 155.Research output: Contribution to journal › Review article › peer-review
Corrigendum to “Single pass tangential flow filtration (SPTFF) of monoclonal antibodies: Experimental studies and theoretical analysis” [J. Membr. Sci. 637 (2021) 119606] (Journal of Membrane Science (2021) 637, (S0376738821005524), (10.1016/j.memsci.2021.119606))
Jabra, M. G., Lipinski, A. M. & Zydney, A. L., Jan 1 2022, In: Journal of Membrane Science. 641, 119953.Research output: Contribution to journal › Comment/debate › peer-review
Design and optimization of Single Pass Tangential Flow Filtration for inline concentration of monoclonal antibodies
Jabra, M. G. & Zydney, A. L., Mar 1 2022, In: Journal of Membrane Science. 643, 120047.Research output: Contribution to journal › Article › peer-review
Development of a transient inline spiking system for evaluating virus clearance in continuous bioprocessing—Proof of concept for virus filtration
Malakian, A., Jung, S. Y., Afzal, M. A., Carbrello, C., Giglia, S., Johnson, M., Miller, C., Rayfield, W., Boenitz, D., Cetlin, D. & Zydney, A. L., Aug 2022, In: Biotechnology and bioengineering. 119, 8, p. 2134-2141 8 p.Research output: Contribution to journal › Article › peer-review
Pressure-dependent fouling behavior during sterile filtration of mRNA-containing lipid nanoparticles
Messerian, K. O., Zverev, A., Kramarczyk, J. F. & Zydney, A. L., 2022, (Accepted/In press) In: Biotechnology and bioengineering.Research output: Contribution to journal › Article › peer-review
Effect of module geometry on the sustainable flux during microfiltration of precipitated IgG
Minervini, M. & Zydney, A. L., Oct 15 2022, In: Journal of Membrane Science. 660, 120834.Research output: Contribution to journal › Article › peer-review
Scale-up issues for commercial depth filters in bioprocessing
Nejatishahidein, N., Kim, M., Jung, S. Y., Borujeni, E. E., Fernandez-Cerezo, L., Roush, D. J., Borhan, A. & Zydney, A. L., Apr 2022, In: Biotechnology and bioengineering. 119, 4, p. 1105-1114 10 p.Research output: Contribution to journal › Article › peer-review
Effect of operating pressure on protein fouling during constant-pressure virus removal filtration
Peles, J., Fallahianbijan, F., Cacace, B., Carbrello, C., Giglia, S. & Zydney, A. L., Apr 15 2022, In: Journal of Membrane Science. 648, 120351.Research output: Contribution to journal › Article › peer-review
Enablers of continuous processing of biotherapeutic products
Rathore, A. S., Zydney, A. L., Anupa, A., Nikita, S. & Gangwar, N., Jul 2022, In: Trends in Biotechnology. 40, 7, p. 804-815 12 p.Research output: Contribution to journal › Review article › peer-review
Bacterial Retention During Filtration of a Live Attenuated Virus Vaccine Through the Sartobran P Sterile Filter
Taylor, N., Morris, M., Wee, A., Ma, W., Kristopeit, A., Wang, S. C. & Zydney, A. L., Jul 2022, In: Journal of Pharmaceutical Sciences. 111, 7, p. 1887-1895 9 p.Research output: Contribution to journal › Article › peer-review
Enhancing the performance of sterile filtration for viral vaccines and model nanoparticles using an appropriate prefilter
Taylor, N., Ma, W., Kristopeit, A., Wang, S. C. & Zydney, A. L., Apr 5 2022, In: Journal of Membrane Science. 647, 120264.Research output: Contribution to journal › Article › peer-review