Research Summary
Current research activities are focused in three distinct areas: artificial organs, bioseparations and membrane processes with the goal is of developing a more fundamental understanding of the factors governing the behavior of these processes, including t
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Research Keywords
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Projects
Recent Publications
Impact of proteins and protein fouling on virus retention during virus removal filtration
Afzal, M. A. & Zydney, A. L., Feb 2024, In: Biotechnology and bioengineering. 121, 2, p. 710-718 9 p.Research output: Contribution to journal › Article › peer-review
Addition of sodium malonate alters the morphology and increases the critical flux during tangential flow filtration of precipitated immunoglobulins
Behboudi, A., Minervini, M., Badinger, Z. S., Haddad, W. W. & Zydney, A. L., Jun 2024, In: Protein Science. 33, 6, e5010.Research output: Contribution to journal › Article › peer-review
Tangential flow filtration for continuous processing of crystallized proteins
Behboudi, A., Minervini, M., Kedzierski, A., Azzariti, L. & Zydney, A. L., May 25 2024, In: Separation and Purification Technology. 336, 126311.Research output: Contribution to journal › Article › peer-review
Filtration of a multi-serotype glycoconjugate vaccine drug product through sterilizing grade 0.2/0.22 µm pore size filters
Du, Z., Qiu, S., Gill, K., Toprani, V. & Zydney, A. L., Feb 2024, In: Biotechnology Journal. 19, 2, 2300450.Research output: Contribution to journal › Article › peer-review
Membrane technology for the purification of RNA and DNA therapeutics
Javidanbardan, A., Messerian, K. O. & Zydney, A. L., Jun 2024, In: Trends in Biotechnology. 42, 6, p. 714-727 14 p.Research output: Contribution to journal › Review article › peer-review
Development of a new modeling framework to describe sterile filtration of mRNA-Lipid nanoparticles
Messerian, K. O., Zverev, A., Kramarczyk, J. F. & Zydney, A. L., Jul 2024, In: Journal of Membrane Science. 706, 122965.Research output: Contribution to journal › Article › peer-review
Optimizing particle morphology during antibody precipitation for enhanced tangential flow filtration performance
Minervini, M., Behboudi, A., Marzella, J. R. & Zydney, A. L., Jun 19 2024, In: Separation and Purification Technology. 338, 126574.Research output: Contribution to journal › Article › peer-review
Buffer effects on protein sieving losses in ultrafiltration and their relationship to biophysical properties
Mohammadzadehmarandi, A. & Zydney, A. L., 2024, (Accepted/In press) In: Biotechnology progress.Research output: Contribution to journal › Article › peer-review
Protein loss during membrane processes in biopharmaceutical manufacturing
Na, J., Behboudi, A., Mun, J., Jin, H., Zydney, A. L. & Baek, Y., May 2024, In: Biotechnology Journal. 19, 5, 2400154.Research output: Contribution to journal › Article › peer-review
Effect of density variations and buoyancy on flow in small-scale depth filter capsules
Naghashnejad, M., Ghajar, G., Fernandez-Cerezo, L., Roush, D. J., Borhan, A. & Zydney, A. L., May 2024, In: Journal of Membrane Science. 702, 122749.Research output: Contribution to journal › Article › peer-review
Co-current filtrate flow in TFF perfusion processes: Decoupling transmembrane pressure from crossflow to improve product sieving
Romann, P., Giller, P., Sibilia, A., Herwig, C., Zydney, A. L., Perilleux, A., Souquet, J., Bielser, J. M. & Villiger, T. K., Feb 2024, In: Biotechnology and bioengineering. 121, 2, p. 640-654 15 p.Research output: Contribution to journal › Article › peer-review
Proteomic analysis of host cell protein fouling during bioreactor harvesting
Zhang, D., Wickramasinghe, S. R., Zydney, A. L., Smelko, J. P., Loman, A., Wheeler, A. & Qian, X., 2024, (Accepted/In press) In: Biotechnology progress.Research output: Contribution to journal › Article › peer-review
The role of intermolecular interactions on monoclonal antibody filtration through virus removal membranes
Billups, M., Minervini, M., Holstein, M., Feroz, H., Ranjan, S., Hung, J. & Zydney, A. L., Dec 2023, In: Biotechnology Journal. 18, 12, 2300265.Research output: Contribution to journal › Article › peer-review
Data-science-based reconstruction of 3-D membrane pore structure using a single 2-D micrograph
Chamani, H., Rabbani, A., Russell, K. P., Zydney, A. L., Gomez, E. D., Hattrick-Simpers, J. & Werber, J. R., Jul 15 2023, In: Journal of Membrane Science. 678, 121673.Research output: Contribution to journal › Article › peer-review
Single-Pass Tangential Flow Filtration (SPTFF) of Nanoparticles: Achieving Sustainable Operation with Dilute Colloidal Suspensions for Gene Therapy Applications
Chaubal, A. S. & Zydney, A. L., Apr 2023, In: Membranes. 13, 4, 433.Research output: Contribution to journal › Article › peer-review