Research Summary
Current research activities are focused in three distinct areas: artificial organs, bioseparations and membrane processes with the goal is of developing a more fundamental understanding of the factors governing the behavior of these processes, including t
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Research Keywords
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Projects
Recent Publications
Development of charged membranes for the ultrafiltration of siRNA
Banik, I., Qian, K. K., Mason, M. L. & Zydney, A. L., Jan 2025, In: Journal of Membrane Science. 713, 123274.Research output: Contribution to journal › Article › peer-review
Vibration-assisted ultrafiltration dramatically improves mRNA purification
Behboudi, A., Javidanbardan, A., Wang, Z., Zhou, L. & Zydney, A. L., Aug 14 2025, In: Separation and Purification Technology. 363, 132179.Research output: Contribution to journal › Article › peer-review
Development of a local wall concentration model for the design of single pass tangential flow filtration (SPTFF) systems with viral vector surrogates
Chaubal, A. S., Single, A. J. & Zydney, A. L., Jan 2025, In: Journal of Membrane Science. 713, 123276.Research output: Contribution to journal › Article › peer-review
Detergent/surfactant retention during ultrafiltration in the formulation of biotherapeutics
Chu, L. K., Du, Z., Billups, M., Oh, H. J. & Zydney, A. L., 2025, (Accepted/In press) In: Biotechnology progress.Research output: Contribution to journal › Article › peer-review
Enhancing Virus Filter Performance Through Pretreatment by Membrane Adsorbers
Isu, S., Chen, S. T., Daneshpour, R., Shirataki, H., Strauss, D., Zydney, A. L., Qian, X. & Wickramasinghe, S. R., Jan 2025, In: Membranes. 15, 1, 34.Research output: Contribution to journal › Article › peer-review
Single-pass tangential flow filtration (SPTFF) for continuous mRNA concentration and purification
Javidanbardan, A., Wang, Z., Kostic, A., Behboudi, A. & Zydney, A. L., Mar 2025, In: Journal of Membrane Science. 719, 123730.Research output: Contribution to journal › Article › peer-review
Flux and fouling behavior during constant pressure sterile filtration of nanoemulsions
Kapila, S., Soukup, R. J., Bradley, M. E. & Zydney, A. L., Jan 2025, In: Journal of Membrane Science. 713, 123370.Research output: Contribution to journal › Article › peer-review
Single particle tracking reveals through-membrane diffusion of bacteriophage during process disruption of virus filtration
Wyllie, I., Afzal, M. A., Shi, A., Zydney, A. L. & Schwartz, D. K., Jan 2025, In: Journal of Membrane Science. 713, 123380.Research output: Contribution to journal › Article › peer-review
Comparative Analysis of the Impact of Protein on Virus Retention for Different Virus Removal Filters
Afzal, M. A., Peles, J. & Zydney, A. L., Jul 2024, In: Membranes. 14, 7, 158.Research output: Contribution to journal › Article › peer-review
Impact of proteins and protein fouling on virus retention during virus removal filtration
Afzal, M. A. & Zydney, A. L., Feb 2024, In: Biotechnology and bioengineering. 121, 2, p. 710-718 9 p.Research output: Contribution to journal › Article › peer-review
Addition of sodium malonate alters the morphology and increases the critical flux during tangential flow filtration of precipitated immunoglobulins
Behboudi, A., Minervini, M., Badinger, Z. S., Haddad, W. W. & Zydney, A. L., Jun 2024, In: Protein Science. 33, 6, e5010.Research output: Contribution to journal › Article › peer-review
Tangential flow filtration for continuous processing of crystallized proteins
Behboudi, A., Minervini, M., Kedzierski, A., Azzariti, L. & Zydney, A. L., May 25 2024, In: Separation and Purification Technology. 336, 126311.Research output: Contribution to journal › Article › peer-review
Filtration of a multi-serotype glycoconjugate vaccine drug product through sterilizing grade 0.2/0.22 µm pore size filters
Du, Z., Qiu, S., Gill, K., Toprani, V. & Zydney, A. L., Feb 2024, In: Biotechnology Journal. 19, 2, 2300450.Research output: Contribution to journal › Article › peer-review
Membrane technology for the purification of RNA and DNA therapeutics
Javidanbardan, A., Messerian, K. O. & Zydney, A. L., Jun 2024, In: Trends in Biotechnology. 42, 6, p. 714-727 14 p.Research output: Contribution to journal › Review article › peer-review
Development of a new modeling framework to describe sterile filtration of mRNA-Lipid nanoparticles
Messerian, K. O., Zverev, A., Kramarczyk, J. F. & Zydney, A. L., Jul 2024, In: Journal of Membrane Science. 706, 122965.Research output: Contribution to journal › Article › peer-review