Research Summary
Current research activities are focused in three distinct areas: artificial organs, bioseparations and membrane processes with the goal is of developing a more fundamental understanding of the factors governing the behavior of these processes, including t
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Research Keywords
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Projects
Recent Publications
Data-science-based reconstruction of 3-D membrane pore structure using a single 2-D micrograph
Chamani, H., Rabbani, A., Russell, K. P., Zydney, A. L., Gomez, E. D., Hattrick-Simpers, J. & Werber, J. R., Jul 15 2023, In: Journal of Membrane Science. 678, 121673.Research output: Contribution to journal › Article › peer-review
Single-Pass Tangential Flow Filtration (SPTFF) of Nanoparticles: Achieving Sustainable Operation with Dilute Colloidal Suspensions for Gene Therapy Applications
Chaubal, A. S. & Zydney, A. L., Apr 2023, In: Membranes. 13, 4, 433.Research output: Contribution to journal › Article › peer-review
Comparison of host cell protein removal by depth filters with diatomaceous earth and synthetic silica filter aids using model proteins
Chu, L. K., Borujeni, E. E., Xu, X., Ghose, S. & Zydney, A. L., Jul 2023, In: Biotechnology and bioengineering. 120, 7, p. 1882-1890 9 p.Research output: Contribution to journal › Article › peer-review
Sterile filtration of a multi-serotype glycoconjugate vaccine drug product
Du, Z., Gill, K., Toprani, V. & Zydney, A. L., May 2023, In: Biotechnology and bioengineering. 120, 5, p. 1316-1322 7 p.Research output: Contribution to journal › Article › peer-review
Smart Manufacturing Implementation of a Continuous Downstream Precipitation and Filtration Process for Antibody Purification
Ghosh, S., Mergy, M., Minervini, M., Okpanum, J., Cramer, S. M., Bequette, B. W., Zydney, A. L. & Przybycien, T. M., Oct 6 2023, In: Smart and Sustainable Manufacturing Systems. 7, 1, p. 129-147 19 p.Research output: Contribution to journal › Article › peer-review
Characterization and associated pressure-dependent behavior of deposits formed during sterile filtration of mRNA-Lipid nanoparticles
Messerian, K. O., Zverev, A., Kramarczyk, J. F. & Zydney, A. L., Oct 15 2023, In: Journal of Membrane Science. 684, 121896.Research output: Contribution to journal › Article › peer-review
Continuous precipitation-filtration process for initial capture of a monoclonal antibody product using a four-stage countercurrent hollow fiber membrane washing step
Minervini, M., Mergy, M., Zhu, Y., Gutierrez Diaz, M. A., Pointer, C., Shinkazh, O., Oppenheim, S. F., Cramer, S. M., Przybycien, T. M. & Zydney, A. L., 2023, (Accepted/In press) In: Biotechnology and bioengineering.Research output: Contribution to journal › Article › peer-review
High-performance countercurrent membrane purification for host cell protein removal from monoclonal antibody products
Mohammadzadehmarandi, A., Determan, A., Krumm, C., McIntosh, L. D. & Zydney, A. L., 2023, (Accepted/In press) In: Biotechnology and bioengineering.Research output: Contribution to journal › Article › peer-review
Protein fouling during constant-flux virus filtration: Mechanisms and modeling
Peles, J., Cacace, B., Carbrello, C., Giglia, S. & Zydney, A. L., Nov 2023, In: Biotechnology and bioengineering. 120, 11, p. 3357-3367 11 p.Research output: Contribution to journal › Article › peer-review
Impact of virus filter pore size / morphology on virus retention behavior
Russell, K. P., Zydney, A. L. & Gomez, E. D., Mar 15 2023, In: Journal of Membrane Science. 670, 121335.Research output: Contribution to journal › Article › peer-review
Use of scanning electron microscopy and energy dispersive X-ray spectroscopy to identify key fouling species during alternating tangential filtration
Sundar, V., Zhang, D., Qian, X., Wickramasinghe, S. R., Smelko, J. P., Carbrello, C., Jabbour Al Maalouf, Y. & Zydney, A. L., May 1 2023, In: Biotechnology progress. 39, 3, e3336.Research output: Contribution to journal › Article › peer-review
Effect of filtrate flux and process disruptions on virus retention by a relatively homogeneous virus removal membrane
Afzal, M. A. & Zydney, A. L., Jul 1 2022, In: Biotechnology progress. 38, 4, e3255.Research output: Contribution to journal › Article › peer-review
Role of membrane structure on the filtrate flux during monoclonal antibody filtration through virus retentive membranes
Billups, M., Minervini, M., Holstein, M., Feroz, H., Ranjan, S., Hung, J., Bao, H., Li, Z. J., Ghose, S. & Zydney, A. L., Mar 1 2022, In: Biotechnology progress. 38, 2, e3231.Research output: Contribution to journal › Article › peer-review
Retention and Fouling during Nanoparticle Filtration: Implications for Membrane Purification of Biotherapeutics
Chu, L. K., Wickramasinghe, S. R., Qian, X. & Zydney, A. L., Mar 2022, In: Membranes. 12, 3, 299.Research output: Contribution to journal › Article › peer-review
Scale-up issues during sterile filtration of glycoconjugate vaccines
Du, Z., Motevalian, S. P., Carrillo Conde, B., Reilly, K. & Zydney, A. L., Jul 1 2022, In: Biotechnology progress. 38, 4, e3260.Research output: Contribution to journal › Article › peer-review