Research Summary
Current research activities are focused in three distinct areas: artificial organs, bioseparations and membrane processes with the goal is of developing a more fundamental understanding of the factors governing the behavior of these processes, including t
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Research Keywords
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Projects
Recent Publications
Downstream Process Intensification for AAV Purification by Affinity Chromatography Using Single Pass Tangential Flow Filtration
Chaubal, A. S., Horax, R., Yehl, C. J., Wickramasinghe, S. R., Qian, X., Wang, L. & Zydney, A. L., Jan 2026, In: Biotechnology and bioengineering. 123, 1, p. 174-185 12 p.Research output: Contribution to journal › Article › peer-review
Characterization of Sterilizing-Grade Membranes/Prefilters and Application to mRNA-LNP Process Development
Messerian, K. O., Zverev, A., Kramarczyk, J. F. & Zydney, A. L., Jan 2026, In: Biotechnology and bioengineering. 123, 1, p. 164-173 10 p.Research output: Contribution to journal › Article › peer-review
Letter to the Editor – Introduction to the 50th Anniversary Special Issue of the Journal of Membrane Science
Zydney, A. L., Jan 2026, In: Journal of Membrane Science. 737, 124746.Research output: Contribution to journal › Letter › peer-review
Enhanced Tangential Flow Filtration of Precipitated Proteins Using Screened Membrane Cassettes
Badinger, Z., Behboudi, A. & Zydney, A. L., Aug 2025, In: Membranes. 15, 8, 245.Research output: Contribution to journal › Article › peer-review
Development of charged membranes for the ultrafiltration of siRNA
Banik, I., Qian, K. K., Mason, M. L. & Zydney, A. L., Jan 2025, In: Journal of Membrane Science. 713, 123274.Research output: Contribution to journal › Article › peer-review
Effect of ligand density and properties on membrane charge for enhancing ultrafiltration of siRNA
Banik, I., Mason, M. L., Carter, M., Qian, K. K. & Zydney, A. L., Dec 31 2025, In: Separation and Purification Technology. 379, 134951.Research output: Contribution to journal › Article › peer-review
Vibration-assisted ultrafiltration dramatically improves mRNA purification
Behboudi, A., Javidanbardan, A., Wang, Z., Zhou, L. & Zydney, A. L., Aug 14 2025, In: Separation and Purification Technology. 363, 132179.Research output: Contribution to journal › Article › peer-review
Development of a local wall concentration model for the design of single pass tangential flow filtration (SPTFF) systems with viral vector surrogates
Chaubal, A. S., Single, A. J. & Zydney, A. L., Jan 2025, In: Journal of Membrane Science. 713, 123276.Research output: Contribution to journal › Article › peer-review
Single pass tangential flow filtration (SPTFF) for concentration and purification of AAV clarified cell lysate
Chaubal, A. S., Yehl, C. J., Afzal, M. A., Wang, L. & Zydney, A. L., Sep 2025, In: Journal of Membrane Science. 733, 124362.Research output: Contribution to journal › Article › peer-review
Detergent/surfactant retention during ultrafiltration in the formulation of biotherapeutics
Chu, L. K., Du, Z., Billups, M., Oh, H. J. & Zydney, A. L., May 1 2025, In: Biotechnology progress. 41, 3, e70011.Research output: Contribution to journal › Article › peer-review
Hydrophobicity analysis of Chinese Hamster Ovary host cell proteins using analytical hydrophobic interaction chromatography and LC-MS
Chu, L. K., Laremore, T., Borujeni, E. E., Xu, X. & Zydney, A. L., Nov 22 2025, In: Journal of Chromatography A. 1763, 466440.Research output: Contribution to journal › Article › peer-review
Use of LC-MS to characterize host cell protein removal during depth filtration
Chu, L. K., Borujeni, E. E., Xu, X. & Zydney, A. L., Sep 1 2025, In: Biotechnology progress. 41, 5, e70044.Research output: Contribution to journal › Article › peer-review
CHO cell deposition during initial stages of clarification using the D0HC commercial depth filter in a Micro 20 capsule
Ghajar, G., Sánchez‐Farrán, M. A., Fernandez-Cerezo, L., Borhan, A. & Zydney, A. L., Oct 2025, In: Journal of Membrane Science. 734, 124424.Research output: Contribution to journal › Article › peer-review
Enhancing Virus Filter Performance Through Pretreatment by Membrane Adsorbers
Isu, S., Chen, S. T., Daneshpour, R., Shirataki, H., Strauss, D., Zydney, A. L., Qian, X. & Wickramasinghe, S. R., Jan 2025, In: Membranes. 15, 1, 34.Research output: Contribution to journal › Article › peer-review
Single-pass tangential flow filtration (SPTFF) for continuous mRNA concentration and purification
Javidanbardan, A., Wang, Z., Kostic, A., Behboudi, A. & Zydney, A. L., Mar 2025, In: Journal of Membrane Science. 719, 123730.Research output: Contribution to journal › Article › peer-review