Andrew Zydney

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Titles and Affiliations
Distinguished Professor, Chemical Engineering

Research Summary

Current research activities are focused in three distinct areas: artificial organs, bioseparations and membrane processes with the goal is of developing a more fundamental understanding of the factors governing the behavior of these processes, including t

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Recent Publications

Effect of filtrate flux and process disruptions on virus retention by a relatively homogeneous virus removal membrane

Afzal, M. A. & Zydney, A. L., Jul 1 2022, In: Biotechnology progress. 38, 4, e3255.

Research output: Contribution to journalArticlepeer-review

Role of membrane structure on the filtrate flux during monoclonal antibody filtration through virus retentive membranes

Billups, M., Minervini, M., Holstein, M., Feroz, H., Ranjan, S., Hung, J., Bao, H., Li, Z. J., Ghose, S. & Zydney, A. L., Mar 1 2022, In: Biotechnology progress. 38, 2, e3231.

Research output: Contribution to journalArticlepeer-review

Retention and Fouling during Nanoparticle Filtration: Implications for Membrane Purification of Biotherapeutics

Chu, L. K., Wickramasinghe, S. R., Qian, X. & Zydney, A. L., Mar 2022, In: Membranes. 12, 3, 299.

Research output: Contribution to journalArticlepeer-review

Scale-up issues during sterile filtration of glycoconjugate vaccines

Du, Z., Motevalian, S. P., Carrillo Conde, B., Reilly, K. & Zydney, A. L., Jul 1 2022, In: Biotechnology progress. 38, 4, e3260.

Research output: Contribution to journalArticlepeer-review

Process-and Product-Related Foulants in Virus Filtration

Isu, S., Qian, X., Zydney, A. L. & Wickramasinghe, S. R., Apr 2022, In: Bioengineering. 9, 4, 155.

Research output: Contribution to journalReview articlepeer-review

Corrigendum to “Single pass tangential flow filtration (SPTFF) of monoclonal antibodies: Experimental studies and theoretical analysis” [J. Membr. Sci. 637 (2021) 119606] (Journal of Membrane Science (2021) 637, (S0376738821005524), (10.1016/j.memsci.2021.119606))

Jabra, M. G., Lipinski, A. M. & Zydney, A. L., Jan 1 2022, In: Journal of Membrane Science. 641, 119953.

Research output: Contribution to journalComment/debatepeer-review

Design and optimization of Single Pass Tangential Flow Filtration for inline concentration of monoclonal antibodies

Jabra, M. G. & Zydney, A. L., Mar 1 2022, In: Journal of Membrane Science. 643, 120047.

Research output: Contribution to journalArticlepeer-review

Development of a transient inline spiking system for evaluating virus clearance in continuous bioprocessing—Proof of concept for virus filtration

Malakian, A., Jung, S. Y., Afzal, M. A., Carbrello, C., Giglia, S., Johnson, M., Miller, C., Rayfield, W., Boenitz, D., Cetlin, D. & Zydney, A. L., Aug 2022, In: Biotechnology and bioengineering. 119, 8, p. 2134-2141 8 p.

Research output: Contribution to journalArticlepeer-review

Pressure-dependent fouling behavior during sterile filtration of mRNA-containing lipid nanoparticles

Messerian, K. O., Zverev, A., Kramarczyk, J. F. & Zydney, A. L., 2022, (Accepted/In press) In: Biotechnology and bioengineering.

Research output: Contribution to journalArticlepeer-review

Effect of module geometry on the sustainable flux during microfiltration of precipitated IgG

Minervini, M. & Zydney, A. L., Oct 15 2022, In: Journal of Membrane Science. 660, 120834.

Research output: Contribution to journalArticlepeer-review

Scale-up issues for commercial depth filters in bioprocessing

Nejatishahidein, N., Kim, M., Jung, S. Y., Borujeni, E. E., Fernandez-Cerezo, L., Roush, D. J., Borhan, A. & Zydney, A. L., Apr 2022, In: Biotechnology and bioengineering. 119, 4, p. 1105-1114 10 p.

Research output: Contribution to journalArticlepeer-review

Effect of operating pressure on protein fouling during constant-pressure virus removal filtration

Peles, J., Fallahianbijan, F., Cacace, B., Carbrello, C., Giglia, S. & Zydney, A. L., Apr 15 2022, In: Journal of Membrane Science. 648, 120351.

Research output: Contribution to journalArticlepeer-review

Enablers of continuous processing of biotherapeutic products

Rathore, A. S., Zydney, A. L., Anupa, A., Nikita, S. & Gangwar, N., Jul 2022, In: Trends in Biotechnology. 40, 7, p. 804-815 12 p.

Research output: Contribution to journalReview articlepeer-review

Bacterial Retention During Filtration of a Live Attenuated Virus Vaccine Through the Sartobran P Sterile Filter

Taylor, N., Morris, M., Wee, A., Ma, W., Kristopeit, A., Wang, S. C. & Zydney, A. L., Jul 2022, In: Journal of Pharmaceutical Sciences. 111, 7, p. 1887-1895 9 p.

Research output: Contribution to journalArticlepeer-review

Enhancing the performance of sterile filtration for viral vaccines and model nanoparticles using an appropriate prefilter

Taylor, N., Ma, W., Kristopeit, A., Wang, S. C. & Zydney, A. L., Apr 5 2022, In: Journal of Membrane Science. 647, 120264.

Research output: Contribution to journalArticlepeer-review