Andrew Zydney

Affiliate Researcher
Titles and Affiliations
Distinguished Professor, Chemical Engineering

Research Summary

Current research activities are focused in three distinct areas: artificial organs, bioseparations and membrane processes with the goal is of developing a more fundamental understanding of the factors governing the behavior of these processes, including t

In the News

Research Keywords

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Projects

Recent Publications

Data-science-based reconstruction of 3-D membrane pore structure using a single 2-D micrograph

Chamani, H., Rabbani, A., Russell, K. P., Zydney, A. L., Gomez, E. D., Hattrick-Simpers, J. & Werber, J. R., Jul 15 2023, In: Journal of Membrane Science. 678, 121673.

Research output: Contribution to journalArticlepeer-review

Single-Pass Tangential Flow Filtration (SPTFF) of Nanoparticles: Achieving Sustainable Operation with Dilute Colloidal Suspensions for Gene Therapy Applications

Chaubal, A. S. & Zydney, A. L., Apr 2023, In: Membranes. 13, 4, 433.

Research output: Contribution to journalArticlepeer-review

Comparison of host cell protein removal by depth filters with diatomaceous earth and synthetic silica filter aids using model proteins

Chu, L. K., Borujeni, E. E., Xu, X., Ghose, S. & Zydney, A. L., Jul 2023, In: Biotechnology and bioengineering. 120, 7, p. 1882-1890 9 p.

Research output: Contribution to journalArticlepeer-review

Sterile filtration of a multi-serotype glycoconjugate vaccine drug product

Du, Z., Gill, K., Toprani, V. & Zydney, A. L., May 2023, In: Biotechnology and bioengineering. 120, 5, p. 1316-1322 7 p.

Research output: Contribution to journalArticlepeer-review

Smart Manufacturing Implementation of a Continuous Downstream Precipitation and Filtration Process for Antibody Purification

Ghosh, S., Mergy, M., Minervini, M., Okpanum, J., Cramer, S. M., Bequette, B. W., Zydney, A. L. & Przybycien, T. M., Oct 6 2023, In: Smart and Sustainable Manufacturing Systems. 7, 1, p. 129-147 19 p.

Research output: Contribution to journalArticlepeer-review

Characterization and associated pressure-dependent behavior of deposits formed during sterile filtration of mRNA-Lipid nanoparticles

Messerian, K. O., Zverev, A., Kramarczyk, J. F. & Zydney, A. L., Oct 15 2023, In: Journal of Membrane Science. 684, 121896.

Research output: Contribution to journalArticlepeer-review

Continuous precipitation-filtration process for initial capture of a monoclonal antibody product using a four-stage countercurrent hollow fiber membrane washing step

Minervini, M., Mergy, M., Zhu, Y., Gutierrez Diaz, M. A., Pointer, C., Shinkazh, O., Oppenheim, S. F., Cramer, S. M., Przybycien, T. M. & Zydney, A. L., 2023, (Accepted/In press) In: Biotechnology and bioengineering.

Research output: Contribution to journalArticlepeer-review

High-performance countercurrent membrane purification for host cell protein removal from monoclonal antibody products

Mohammadzadehmarandi, A., Determan, A., Krumm, C., McIntosh, L. D. & Zydney, A. L., 2023, (Accepted/In press) In: Biotechnology and bioengineering.

Research output: Contribution to journalArticlepeer-review

Protein fouling during constant-flux virus filtration: Mechanisms and modeling

Peles, J., Cacace, B., Carbrello, C., Giglia, S. & Zydney, A. L., Nov 2023, In: Biotechnology and bioengineering. 120, 11, p. 3357-3367 11 p.

Research output: Contribution to journalArticlepeer-review

Impact of virus filter pore size / morphology on virus retention behavior

Russell, K. P., Zydney, A. L. & Gomez, E. D., Mar 15 2023, In: Journal of Membrane Science. 670, 121335.

Research output: Contribution to journalArticlepeer-review

Use of scanning electron microscopy and energy dispersive X-ray spectroscopy to identify key fouling species during alternating tangential filtration

Sundar, V., Zhang, D., Qian, X., Wickramasinghe, S. R., Smelko, J. P., Carbrello, C., Jabbour Al Maalouf, Y. & Zydney, A. L., May 1 2023, In: Biotechnology progress. 39, 3, e3336.

Research output: Contribution to journalArticlepeer-review

Effect of filtrate flux and process disruptions on virus retention by a relatively homogeneous virus removal membrane

Afzal, M. A. & Zydney, A. L., Jul 1 2022, In: Biotechnology progress. 38, 4, e3255.

Research output: Contribution to journalArticlepeer-review

Role of membrane structure on the filtrate flux during monoclonal antibody filtration through virus retentive membranes

Billups, M., Minervini, M., Holstein, M., Feroz, H., Ranjan, S., Hung, J., Bao, H., Li, Z. J., Ghose, S. & Zydney, A. L., Mar 1 2022, In: Biotechnology progress. 38, 2, e3231.

Research output: Contribution to journalArticlepeer-review

Retention and Fouling during Nanoparticle Filtration: Implications for Membrane Purification of Biotherapeutics

Chu, L. K., Wickramasinghe, S. R., Qian, X. & Zydney, A. L., Mar 2022, In: Membranes. 12, 3, 299.

Research output: Contribution to journalArticlepeer-review

Scale-up issues during sterile filtration of glycoconjugate vaccines

Du, Z., Motevalian, S. P., Carrillo Conde, B., Reilly, K. & Zydney, A. L., Jul 1 2022, In: Biotechnology progress. 38, 4, e3260.

Research output: Contribution to journalArticlepeer-review