Research Summary
Our research focus is on mechanisms of cancer - a development in squamous epithelia. We focus primarily on the role of Transforming Growth Factor Beta (TGFβ) and its signaling pathway in the regulation of tumor promotion and progression.
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Recent Publications
Re-engineering Antimicrobial Peptides into Oncolytics Targeting Drug-Resistant Ovarian Cancers
Aronson, M. R., Dahl, E. S., Halle, J. A., Simonson, A. W., Gogal, R. A., Glick, A. B., Aird, K. M. & Medina, S. H., Oct 1 2020, In: Cellular and Molecular Bioengineering. 13, 5, p. 447-461 15 p.Research output: Contribution to journal › Article › peer-review
Photocontrolled miR-148b nanoparticles cause apoptosis, inflammation and regression of Ras induced epidermal squamous cell carcinomas in mice
Liu, Y., Bailey, J. T., Abu-Laban, M., Li, S., Chen, C., Glick, A. B. & Hayes, D. J., Oct 2020, In: Biomaterials. 256, 120212.Research output: Contribution to journal › Article › peer-review
Ultrasound-Guided Cytosolic Protein Delivery via Transient Fluorous Masks
Sloand, J. N., Nguyen, T. T., Zinck, S. A., Cook, E. C., Zimudzi, T. J., Showalter, S. A., Glick, A. B., Simon, J. C. & Medina, S. H., Apr 28 2020, In: ACS nano. 14, 4, p. 4061-4073 13 p.Research output: Contribution to journal › Article › peer-review
The multiple roles of the unfolded protein response regulator IRE1α in cancer
Chalmers, F., Mogre, S., Son, J., Blazanin, N. & Glick, A. B., Sep 2019, In: Molecular Carcinogenesis. 58, 9, p. 1623-1630 8 p.Research output: Contribution to journal › Article › peer-review
ER stress and distinct outputs of the IRE1α RNase control proliferation and senescence in response to oncogenic Ras
Blazanin, N., Son, J., Craig-Lucas, A. B., John, C. L., Breech, K. J., Podolsky, M. A. & Glick, A. B., Sep 12 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 37, p. 9900-9905 6 p.Research output: Contribution to journal › Article › peer-review
Differentiated state of initiating tumor cells is key to distinctive immune responses seen in H-RasG12V-induced squamous tumors
Podolsky, M. A., Bailey, J. T., Gunderson, A. J., Oakes, C. J., Breech, K. & Glick, A. B., Mar 2017, In: Cancer Immunology Research. 5, 3, p. 198-210 13 p.Research output: Contribution to journal › Article › peer-review
Ah receptor activation potentiates neutrophil chemoattractant (C-X-C Motif) ligand 5 expression in keratinocytes and skin
Smith, K. J., Boyer, J. A., Muku, G. E., Murray, I. A., Gowda, K., Desai, D., Amin, S. G., Glick, A. B. & Perdew, G. H., Nov 1 2017, In: Toxicological Sciences. 160, 1, p. 83-94 12 p.Research output: Contribution to journal › Article › peer-review
Estrogen modulates mesenchyme-epidermis interactions in the adult nipple
Wu, H. J., Oh, J. W., Spandau, D. F., Tholpady, S., Diaz, J., Schroeder, L. J., Offutt, C. D., Glick, A. B., Plikus, M. V., Koyama, S. & Foley, J., Apr 15 2017, In: Development (Cambridge). 144, 8, p. 1498-1509 12 p.Research output: Contribution to journal › Article › peer-review
Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation
Van Den Bogaard, E. H., Podolsky, M. A., Smits, J. P., Cui, X., John, C., Gowda, K., Desai, D., Amin, S. G., Schalkwijk, J., Perdew, G. H. & Glick, A. B., May 22 2015, In: Journal of Investigative Dermatology. 135, 5, p. 1320-1328 9 p.Research output: Contribution to journal › Article › peer-review