Research Summary
Our research focus is on mechanisms of cancer - a development in squamous epithelia. We focus primarily on the role of Transforming Growth Factor Beta (TGFβ) and its signaling pathway in the regulation of tumor promotion and progression.
In the News
Research Keywords
These keywords and phrases come from the publications and other research output of this person. See other researchers related to these topics by clicking on any keyword.
Recent Publications
Near-Infrared Induced miR-34a Delivery from Nanoparticles in Esophageal Cancer Treatment
Alden, N. A., Yeingst, T. J., Pfeiffer, H. M., Celik, N., Arrizabalaga, J. H., Helton, A. M., Liu, Y., Stairs, D. B., Glick, A. B., Goyal, N. & Hayes, D. J., Apr 17 2024, In: Advanced Healthcare Materials. 13, 10, 2303593.Research output: Contribution to journal › Article › peer-review
RAS-activated PI3K/AKT signaling sustains cellular senescence via P53/P21 axis in experimental models of psoriasis
Mercurio, L., Bailey, J., Glick, A. B., Dellambra, E., Scarponi, C., Pallotta, S., Albanesi, C. & Madonna, S., Jul 2024, In: Journal of Dermatological Science. 115, 1, p. 21-32 12 p.Research output: Contribution to journal › Article › peer-review
IRE1α regulates ROS and immune responses after UVB irradiation
Son, J., Bailey, J. T., Worrell, S. & Glick, A. B., Jan 2024, In: Redox Experimental Medicine. 2024, 1, e230030.Research output: Contribution to journal › Article › peer-review
Activation of Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) in Keratinocytes by Endogenous Fatty Acids
Zhu, B., Zhu, X., Borland, M. G., Ralph, D. H., Chiaro, C. R., Krausz, K. W., Ntambi, J. M., Glick, A. B., Patterson, A. D., Perdew, G. H., Gonzalez, F. J. & Peters, J. M., Jun 2024, In: Biomolecules. 14, 6, 606.Research output: Contribution to journal › Article › peer-review
Delivery of Therapeutic miR-148b Mimic via Poly(β Amino Ester) Polyplexes for Post-transcriptional Gene Regulation and Apoptosis of A549 Cells
Alden, N. A., Arrizabalaga, J. H., Liu, Y., Amin, S., Gowda, K., Yao, S., Archetti, M., Glick, A. B. & Hayes, D. J., Aug 16 2022, In: Langmuir. 38, 32, p. 9833-9843 11 p.Research output: Contribution to journal › Article › peer-review
Targeted deletion of TGFβ1 in basal keratinocytes causes profound defects in stratified squamous epithelia and aberrant melanocyte migration
Chalmers, F. E., Dusold, J. E., Shaik, J. A., Walsh, H. A. & Glick, A. B., May 2022, In: Developmental biology. 485, p. 9-23 15 p.Research output: Contribution to journal › Article › peer-review
The unfolded protein response gene Ire1α is required for tissue renewal and normal differentiation in the mouse tongue and esophagus
Chalmers, F. E., Mogre, S., Rimal, B., Son, J., Patterson, A. D., Stairs, D. B. & Glick, A. B., Dec 2022, In: Developmental biology. 492, p. 59-70 12 p.Research output: Contribution to journal › Article › peer-review
TGFβ1 regulates HRas-mediated activation of IRE1α through the PERK-RPAP2 axis in keratinocytes
Mogre, S., Blazanin, N., Walsh, H., Ibinson, J., Minnich, C., Andrew Hu, C. C. & Glick, A. B., Oct 2022, In: Molecular Carcinogenesis. 61, 10, p. 958-971 14 p.Research output: Contribution to journal › Article › peer-review
The Endoplasmic Reticulum Stress Sensor IRE1α Regulates the UV DNA Repair Response through the Control of Intracellular Calcium Homeostasis
Son, J., Mogre, S., Chalmers, F. E., Ibinson, J., Worrell, S. & Glick, A. B., Jun 2022, In: Journal of Investigative Dermatology. 142, 6, p. 1682-1691.e7Research output: Contribution to journal › Article › peer-review
Re-engineering Antimicrobial Peptides into Oncolytics Targeting Drug-Resistant Ovarian Cancers
Aronson, M. R., Dahl, E. S., Halle, J. A., Simonson, A. W., Gogal, R. A., Glick, A. B., Aird, K. M. & Medina, S. H., Oct 1 2020, In: Cellular and Molecular Bioengineering. 13, 5, p. 447-461 15 p.Research output: Contribution to journal › Article › peer-review
Photocontrolled miR-148b nanoparticles cause apoptosis, inflammation and regression of Ras induced epidermal squamous cell carcinomas in mice
Liu, Y., Bailey, J. T., Abu-Laban, M., Li, S., Chen, C., Glick, A. B. & Hayes, D. J., Oct 2020, In: Biomaterials. 256, 120212.Research output: Contribution to journal › Article › peer-review
Ultrasound-Guided Cytosolic Protein Delivery via Transient Fluorous Masks
Sloand, J. N., Nguyen, T. T., Zinck, S. A., Cook, E. C., Zimudzi, T. J., Showalter, S. A., Glick, A. B., Simon, J. C. & Medina, S. H., Apr 28 2020, In: ACS nano. 14, 4, p. 4061-4073 13 p.Research output: Contribution to journal › Article › peer-review
The multiple roles of the unfolded protein response regulator IRE1α in cancer
Chalmers, F., Mogre, S., Son, J., Blazanin, N. & Glick, A. B., Sep 2019, In: Molecular Carcinogenesis. 58, 9, p. 1623-1630 8 p.Research output: Contribution to journal › Article › peer-review
ER stress and distinct outputs of the IRE1α RNase control proliferation and senescence in response to oncogenic Ras
Blazanin, N., Son, J., Craig-Lucas, A. B., John, C. L., Breech, K. J., Podolsky, M. A. & Glick, A. B., Sep 12 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 37, p. 9900-9905 6 p.Research output: Contribution to journal › Article › peer-review
Differentiated state of initiating tumor cells is key to distinctive immune responses seen in H-RasG12V-induced squamous tumors
Podolsky, M. A., Bailey, J. T., Gunderson, A. J., Oakes, C. J., Breech, K. & Glick, A. B., Mar 2017, In: Cancer Immunology Research. 5, 3, p. 198-210 13 p.Research output: Contribution to journal › Article › peer-review