Adam Glick

IEE Faculty Member
Titles and Affiliations
Associate Professor, Veterinary and Biomedical Sciences

Research Summary

Our research focus is on mechanisms of cancer - a development in squamous epithelia. We focus primarily on the role of Transforming Growth Factor Beta (TGFβ) and its signaling pathway in the regulation of tumor promotion and progression.

In the News

Research Keywords

Recent Publications

Near-Infrared Induced miR-34a Delivery from Nanoparticles in Esophageal Cancer Treatment

Alden, N. A., Yeingst, T. J., Pfeiffer, H. M., Celik, N., Arrizabalaga, J. H., Helton, A. M., Liu, Y., Stairs, D. B., Glick, A. B., Goyal, N. & Hayes, D. J., Apr 17 2024, In: Advanced Healthcare Materials. 13, 10, 2303593.

Research output: Contribution to journalArticlepeer-review

RAS-activated PI3K/AKT signaling sustains cellular senescence via P53/P21 axis in experimental models of psoriasis

Mercurio, L., Bailey, J., Glick, A. B., Dellambra, E., Scarponi, C., Pallotta, S., Albanesi, C. & Madonna, S., Jul 2024, In: Journal of Dermatological Science. 115, 1, p. 21-32 12 p.

Research output: Contribution to journalArticlepeer-review

Activation of Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) in Keratinocytes by Endogenous Fatty Acids

Zhu, B., Zhu, X., Borland, M. G., Ralph, D. H., Chiaro, C. R., Krausz, K. W., Ntambi, J. M., Glick, A. B., Patterson, A. D., Perdew, G. H., Gonzalez, F. J. & Peters, J. M., Jun 2024, In: Biomolecules. 14, 6, 606.

Research output: Contribution to journalArticlepeer-review

Delivery of Therapeutic miR-148b Mimic via Poly(β Amino Ester) Polyplexes for Post-transcriptional Gene Regulation and Apoptosis of A549 Cells

Alden, N. A., Arrizabalaga, J. H., Liu, Y., Amin, S., Gowda, K., Yao, S., Archetti, M., Glick, A. B. & Hayes, D. J., Aug 16 2022, In: Langmuir. 38, 32, p. 9833-9843 11 p.

Research output: Contribution to journalArticlepeer-review

Targeted deletion of TGFβ1 in basal keratinocytes causes profound defects in stratified squamous epithelia and aberrant melanocyte migration

Chalmers, F. E., Dusold, J. E., Shaik, J. A., Walsh, H. A. & Glick, A. B., May 2022, In: Developmental biology. 485, p. 9-23 15 p.

Research output: Contribution to journalArticlepeer-review

The unfolded protein response gene Ire1α is required for tissue renewal and normal differentiation in the mouse tongue and esophagus

Chalmers, F. E., Mogre, S., Rimal, B., Son, J., Patterson, A. D., Stairs, D. B. & Glick, A. B., Dec 2022, In: Developmental biology. 492, p. 59-70 12 p.

Research output: Contribution to journalArticlepeer-review

TGFβ1 regulates HRas-mediated activation of IRE1α through the PERK-RPAP2 axis in keratinocytes

Mogre, S., Blazanin, N., Walsh, H., Ibinson, J., Minnich, C., Andrew Hu, C. C. & Glick, A. B., Oct 2022, In: Molecular Carcinogenesis. 61, 10, p. 958-971 14 p.

Research output: Contribution to journalArticlepeer-review

The Endoplasmic Reticulum Stress Sensor IRE1α Regulates the UV DNA Repair Response through the Control of Intracellular Calcium Homeostasis

Son, J., Mogre, S., Chalmers, F. E., Ibinson, J., Worrell, S. & Glick, A. B., Jun 2022, In: Journal of Investigative Dermatology. 142, 6, p. 1682-1691.e7

Research output: Contribution to journalArticlepeer-review

Re-engineering Antimicrobial Peptides into Oncolytics Targeting Drug-Resistant Ovarian Cancers

Aronson, M. R., Dahl, E. S., Halle, J. A., Simonson, A. W., Gogal, R. A., Glick, A. B., Aird, K. M. & Medina, S. H., Oct 1 2020, In: Cellular and Molecular Bioengineering. 13, 5, p. 447-461 15 p.

Research output: Contribution to journalArticlepeer-review

Photocontrolled miR-148b nanoparticles cause apoptosis, inflammation and regression of Ras induced epidermal squamous cell carcinomas in mice

Liu, Y., Bailey, J. T., Abu-Laban, M., Li, S., Chen, C., Glick, A. B. & Hayes, D. J., Oct 2020, In: Biomaterials. 256, 120212.

Research output: Contribution to journalArticlepeer-review

Ultrasound-Guided Cytosolic Protein Delivery via Transient Fluorous Masks

Sloand, J. N., Nguyen, T. T., Zinck, S. A., Cook, E. C., Zimudzi, T. J., Showalter, S. A., Glick, A. B., Simon, J. C. & Medina, S. H., Apr 28 2020, In: ACS nano. 14, 4, p. 4061-4073 13 p.

Research output: Contribution to journalArticlepeer-review

The multiple roles of the unfolded protein response regulator IRE1α in cancer

Chalmers, F., Mogre, S., Son, J., Blazanin, N. & Glick, A. B., Sep 2019, In: Molecular Carcinogenesis. 58, 9, p. 1623-1630 8 p.

Research output: Contribution to journalArticlepeer-review

ER stress and distinct outputs of the IRE1α RNase control proliferation and senescence in response to oncogenic Ras

Blazanin, N., Son, J., Craig-Lucas, A. B., John, C. L., Breech, K. J., Podolsky, M. A. & Glick, A. B., Sep 12 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 37, p. 9900-9905 6 p.

Research output: Contribution to journalArticlepeer-review

Differentiated state of initiating tumor cells is key to distinctive immune responses seen in H-RasG12V-induced squamous tumors

Podolsky, M. A., Bailey, J. T., Gunderson, A. J., Oakes, C. J., Breech, K. & Glick, A. B., Mar 2017, In: Cancer Immunology Research. 5, 3, p. 198-210 13 p.

Research output: Contribution to journalArticlepeer-review

Ah receptor activation potentiates neutrophil chemoattractant (C-X-C Motif) ligand 5 expression in keratinocytes and skin

Smith, K. J., Boyer, J. A., Muku, G. E., Murray, I. A., Gowda, K., Desai, D., Amin, S. G., Glick, A. B. & Perdew, G. H., Nov 1 2017, In: Toxicological Sciences. 160, 1, p. 83-94 12 p.

Research output: Contribution to journalArticlepeer-review