Jack Vanden Heuvel

Affiliate Researcher
Titles and Affiliations
Professor of Veterinary Science, Veterinary and Biomedical Sciences

Research Summary

Research is focused on the three likely candidates for NRs that respond to dietary fatty acids: PPAR, RXR and LXR. In particular, the peroxisome proliferator-activated receptors (PPARs; PPARa, ß/d and ?) are of particular interest as they serve key roles in toxicology, carcinogenesis and nutrition. Study the ligands of these receptors, the genes they affect and the physiological consequences of their activation.

In the News

Research Keywords

Projects

Recent Publications

Lipoxygenase catalyzed metabolites derived from docosahexaenoic acid are promising antitumor agents against breast cancer

Chen, K. M., Thompson, H., Vanden-Heuvel, J. P., Sun, Y. W., Trushin, N., Aliaga, C., Gowda, K., Amin, S., Stanley, B., Manni, A. & El-Bayoumy, K., Dec 2021, In: Scientific reports. 11, 1, 410.

Research output: Contribution to journalArticlepeer-review

Accumulating evidence to support the safe and efficacious use of a proprietary blend of capsaicinoids in mediating risk factors for obesity

Mariwala, J. K., Rai, D., Padigaru, M., Ashok Morde, A., Maddox, E., Maalouf, S., Smith, K. & Vanden Heuvel, J. P., Jun 2021, In: Food Science and Nutrition. 9, 6, p. 2823-2835 13 p.

Research output: Contribution to journalArticlepeer-review

Detection and removal of biologically active organic micropollutants from hospital wastewater

Castillo Meza, L., Piotrowski, P., Farnan, J., Tasker, T. L., Xiong, B., Weggler, B., Murrell, K., Dorman, F. L., Vanden Heuvel, J. P. & Burgos, W. D., Jan 15 2020, In: Science of the Total Environment. 700, 134469.

Research output: Contribution to journalArticlepeer-review

Diets low in saturated fat with different unsaturated fatty acid profiles similarly increase serum-mediated cholesterol efflux from THP-1 macrophages in a population with or at risk for metabolic syndrome: The Canola Oil Multicenter Intervention Trial

Liu, X., Garban, J., Jones, P. J., Heuvel, J. V., Lamarche, B., Jenkins, D. J., Connelly, P. W., Couture, P., Pu, S., Fleming, J. A., West, S. G. & Kris-Etherton, P. M., May 1 2018, In: Journal of Nutrition. 148, 5, p. 721-728 8 p.

Research output: Contribution to journalArticlepeer-review

Environmental and Human Health Impacts of Spreading Oil and Gas Wastewater on Roads

Tasker, T. L., Burgos, W. D., Piotrowski, P., Castillo-Meza, L., Blewett, T. A., Ganow, K. B., Stallworth, A., Delompré, P. L. M., Goss, G. G., Fowler, L. B., Vanden Heuvel, J. P., Dorman, F. & Warner, N. R., Jun 19 2018, In: Environmental Science and Technology. 52, 12, p. 7081-7091 11 p.

Research output: Contribution to journalArticlepeer-review

Replication study: Systematic identification of genomic markers of drug sensitivity in cancer cells

Reproducibility Project: Cancer Biology, Jan 9 2018, In: eLife. 7, e29747.

Research output: Contribution to journalArticlepeer-review

Effects of cranberry extracts on gene expression in THP-1 cells

Hannon, D. B., Thompson, J. T., Khoo, C., Juturu, V. & Vanden Heuvel, J. P., Jan 1 2017, In: Food Science and Nutrition. 5, 1, p. 148-159 12 p.

Research output: Contribution to journalArticlepeer-review

Biliverdin reductase A attenuates hepatic steatosis by inhibition of Glycogen Synthase Kinase (GSK) 3β phosphorylation of serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α

Hinds, T. D., Burns, K. A., Hosick, P. A., McBeth, L., Nestor-Kalinoski, A., Drummond, H. A., Alamodi, A. A., Hankins, M. W., Vanden Heuvel, J. P. & Stec, D. E., Nov 25 2016, In: Journal of Biological Chemistry. 291, 48, p. 25179-25191 13 p.

Research output: Contribution to journalArticlepeer-review

Therapeutic potential of GW501516 and the role of Peroxisome proliferator-activated receptor β/δ and B-cell lymphoma 6 in inflammatory signaling in human pancreatic cancer cells

Smith, R. W., Coleman, J. D., Thompson, J. T. & Vanden Heuvel, J. P., Dec 1 2016, In: Biochemistry and Biophysics Reports. 8, p. 395-402 8 p.

Research output: Contribution to journalArticlepeer-review

Registered report: Systematic identification of genomic markers of drug sensitivity in cancer cells

Reproducibility Project: Cancer Biology, Jun 23 2016, In: eLife. 5, JUNE2016, e13620.

Research output: Contribution to journalArticlepeer-review

Differential nucleobase protection against 5-fluorouracil toxicity for squamous and columnar cells: Implication for tissue function and oncogenesis

Vanden Heuvel, J. P., Thompson, J. T., Albrecht, P., Mandetta, D., Kamerow, H. & Ford, J. P., Oct 22 2015, In: Investigational New Drugs. 33, 5, p. 1003-1011 9 p.

Research output: Contribution to journalArticlepeer-review

Effects of whole and refined grains in a weight-loss diet on markers of metabolic syndrome in individuals with increased waist circumference: A randomized controlled-feeding trial

Jackson, K. H., West, S. G., Vanden Heuvel, J. P., Jonnalagadda, S. S., Ross, A. B., Hill, A. M., Grieger, J. A., Lemieux, S. K. & Kris-Etherton, P. M., 2014, In: American Journal of Clinical Nutrition. 100, 2, p. 577-586 10 p.

Research output: Contribution to journalArticlepeer-review

Effects of a DASH-like diet containing lean beef on vascular health

Roussell, M. A., Hill, A. M., Gaugler, T. L., West, S. G., Ulbrecht, J. S., Vanden Heuvel, J. P., Gillies, P. J. & Kris-Etherton, P. M., Jan 1 2014, In: Journal of Human Hypertension. 28, 10, p. 600-605 6 p.

Research output: Contribution to journalArticlepeer-review

Role of peroxisome proliferator-activated receptor β/δ and B-cell lymphoma-6 in regulation of genes involved in metastasis and migration in pancreatic cancer cells

Coleman, J. D., Thompson, J. T., Smith, R. W., Prokopczyk, B. & Vanden Heuvel, J. P., 2013, In: PPAR Research. 121956.

Research output: Contribution to journalArticlepeer-review

Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors

Paul, K. B., Thompson, J. T., Simmons, S. O., Vanden Heuvel, J. P. & Crofton, K. M., Oct 2013, In: Toxicology in Vitro. 27, 7, p. 2049-2060 12 p.

Research output: Contribution to journalArticlepeer-review