Genetics and its many subfields have made strides in their attempt to define the flow of information that underlies how living things operate. This has created a landscape full of intrigue, complexity, and controversy, as we deal squarely with who we are as a species, and most importantly, what underlies the differences in phenotypes and fates. In this seminar, I introduce the idea of a “Biology nexus,” a new understanding of biology that can rigorously and responsibly incorporate multiple understandings about life—including the molecular, technological, social, and contextual—into a more complete picture of who we are and why we are different. In doing so, we create a more rigorous dogma that embodies, rather than regresses, the statistical noise and capriciousness that underlies modern genetics.